Reviews in Cardiovascular Medicine,
Год журнала:
2024,
Номер
25(11)
Опубликована: Ноя. 22, 2024
Atherosclerosis
(AS)
is
an
important
cause
of
morbidity
and
mortality
in
cardiovascular
diseases
such
as
coronary
atherosclerotic
heart
disease
stroke.
As
the
primary
natural
barrier
between
blood
vessel
wall,
damage
to
vascular
endothelial
cells
(VECs)
one
initiating
factors
for
development
AS.
VECs
primarily
use
aerobic
glycolysis
energy
supply,
but
several
can
altered
glucose
metabolism
VECs.
Glucose
reprogramming
core
event
AS,
which
closely
related
In
this
review,
we
review
how
promotes
AS
by
inducing
VEC
dysfunction,
autophagy,
altering
inflammatory
response,
proliferation
VECs,
hopes
providing
new
ideas
discovering
targets
prevention
treatment
Cell Biology and Toxicology,
Год журнала:
2025,
Номер
41(1)
Опубликована: Янв. 7, 2025
Vascular
endothelial
cell-derived
exosomes
are
thought
to
mediate
disease
progression
by
regulating
macrophage
polarization.
However,
its
mechanism
in
diabetes
mellitus
(DM)-related
atherosclerosis
(AS)
progress
is
unclear.
High-glucose
(HG)
and
oxLDL
were
used
induce
human
cardiac
microvascular
cells
(HCMECs)
mimic
DM-related
AS
model.
The
conditioned
medium
(CM)
from
HG+oxLDL-induced
HCMECs
was
incubated
with
THP1-M0
monocytes
treated
LPS
or
oxLDL.
mRNA
levels
of
M1/M2
polarization
markers,
NEDD4L,
IκBα
PPARγ
determined
qRT-PCR.
Flow
cytometry
analyze
marker.
Dil-labeled
oil
red
O
staining
performed
assess
uptake
cells.
inflammatory
factors
examined
using
ELISA.
Transmission
electron
microscope
for
observing
foam
cell
formation
exosome
morphology.
protein
p-Smad1/Smad1,
p-Smad2/Smad2,
p-IκBα/IκBα,
p-P65/P65,
anti-lipid
metabolism-related
NEDD4L
tested
western
blot.
interaction
between
assessed
Co-IP
assay.
CM
could
promote
M1
polarization,
formation,
inhibiter
GW4869
eliminated
these
effects.
overexpressed
HCMECs,
which
be
taken
up
Exosomal
knockdown
inhibited
reducing
the
p-IκBα/IκBα
p-P65/P65.
reduce
expression
through
ubiquitination.
HCMECs-derived
exosomal
enhance
ubiquitination
facilitate
uptake,
thus
accelerating
AS.
Journal of Diabetology,
Год журнала:
2025,
Номер
16(1), С. 1 - 13
Опубликована: Янв. 1, 2025
Abstract
Background:
The
complications
of
diabetes
mellitus
(DM)
have
incapacitated
many
patients,
especially
in
poor-income
countries.
DM
is
an
endocrine
disease
but
its
far-reaching
arise
from
cardiovascular
derangements.
usually
stem
endothelial
dysfunction,
which
culminates
atherosclerosis.
Progressively,
atherosclerosis
results
microvascular
and
macrovascular
complications.
Materials
Methods:
Literature
searches
were
carried
out
Google,
PubMed,
MEDLINE
using
the
following
keywords:
DM,
biomarkers,
anti-diabetic
drugs,
C-reactive
protein
(CRP),
intercellular
adhesion
molecule.
Original
articles,
systematic
reviews,
meta-analytic
articles
reviewed,
important
findings
incorporated
into
this
review.
Summary:
review
aims
to
evaluate
mechanisms
responsible
for
dysfunction
diabetes.
Endothelial
may
one
or
a
combination
these
molecular
mechanisms:
(i)
decreased
nitric
oxide
synthesis,
(ii)
activation
kinase
C
reactive
oxygen
species
generation,
(iii)
activity
advanced
glycation
endproducts,
(iv)
tumor
necrosis
factor-alpha,
defective
insulin
signaling
so
on.
biomarkers
also
explored
they
include
CRP,
intracellular
molecule-1,
vascular
cell
microalbuminuria,
asymmetric
dimethylarginine,
Toll-like
receptors,
others.
evaluated
effectiveness
medications
modulating
diabetic
patients.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 13, 2025
Background
The
effects
of
resveratrol
supplementation
on
inflammation
and
oxidative
stress
in
patients
with
type
2
diabetes
mellitus
(T2DM)
were
controversial.
A
meta-analysis
was
performed
to
assess
the
changes
levels
T2DM.
Methods
Relevant
literatures
before
November
6,
2024
screened
through
Web
Science,Embase,the
Cochrane
Library
other
sources
(ClinicalTrials,
ProQuest
Dissertations
Theses).
quality
literature
evaluated
according
Handbook
Systematic
Reviews.
study
assessed
using
risk-of-bias
tool
Grading
Recommendations
Assessment,Development
Evaluation
(GRADE)
system.
Review
Manager
5.3
conducted
data
included
literature.
Results
This
six
randomized
controlled
trials
involving
533
participants.
Our
results
showed
that
significantly
reduced
C-reactive
protein
levels(SMD
=
-1.40,
95%CI(-2.60,
-0.21),
P
0.02;
Level
evidence:
low),
lipid
peroxide
(SMD
-0.99,
95%CI(-1.36,
-0.61),
<
0.00001;
8-isoprostanes(SMD
-0.79,
95%CI(-1.16,
-0.42),
0.0001;
low)
score
-1.62,
95%CI(-2.49,
-0.75),
0.0003;
very
low).
In
addition,
compared
placebo,
Supplementation
increased
glutathione
peroxidase
0.38,
95%CI(0.03,
0.74),
0.04;
evidence:low)
catalase
0.33,
0.63),
0.03;
However,
no
significant
difference
observed
improving
interleukin-6
-1.35,
95%CI(-2.75,
-0.05),
0.06;
tumor
necrosis
factor
α
-3.30,
95%CI(-7.47,
0.87),
0.12;
superoxide
dismutase
0.39,
95%CI(-0.26,
1.04),
0.24;
total
antioxidant
capacity
95%CI(-0.23,
1.00),
0.21;
malondialdehyde
-3.36,
95%CI(-10.30,
3.09),
0.29;
Conclusion
Resveratrol
improved
T2DM
some
extent.
provides
a
new
idea
method
for
clinical
treatment.
due
limitations
study,
more
large-sample,
multi-center
studies
are
needed
verify
this
conclusion.
