Mitochondrial function: A new direction for the targeted treatment of cardiovascular diseases with Chinese herbal medicine
Journal of Holistic Integrative Pharmacy,
Год журнала:
2025,
Номер
6(1), С. 91 - 104
Опубликована: Март 1, 2025
Язык: Английский
Acacetin as a natural cardiovascular therapeutic: mechanisms and preclinical evidence
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 4, 2025
Globally,
cardiovascular
disease
(CVD)
has
emerged
as
a
leading
cause
of
mortality
and
morbidity.
As
the
world’s
population
ages,
CVD
incidence
is
on
rise,
extensive
attention
been
drawn
to
optimizing
therapeutic
regimens.
Acacetin,
natural
flavonoid
derived
from
various
plants,
demonstrated
have
wide
spectrum
pharmacological
properties,
such
antioxidant,
anti-inflammatory,
anti-bacterial,
anti-tumor
activities,
well
protective
effects
diverse
tissues
organs.
Recently,
increasing
numbers
studies
(mostly
preclinical)
indicated
that
acacetin
potential
might
become
novel
strategy
for
CVDs.
The
importance
in
treatment
necessitates
systematic
comprehensive
review
its
system
underlying
mechanisms
involved.
Here,
we
first
provide
an
overview
some
basic
properties
acacetin.
Subsequently,
multiple
CVDs,
like
arrhythmias,
cardiac
ischemia/reperfusion
injury,
atherosclerosis,
myocardial
hypertrophy
fibrosis,
drug-induced
cardiotoxicity,
diabetic
cardiomyopathy,
hypertension,
senescence,
are
discussed
detail.
by
which
exhibits
protection
appear
involve
suppressing
oxidative
stress,
reducing
inflammation,
preventing
cardiomyocyte
apoptosis
endothelial
cell
regulating
mitochondrial
autophagy
lipid
metabolism.
Meanwhile,
several
critical
signaling
pathways
also
found
mediate
against
including
phosphoinositide
3-kinase/protein
kinase
B/mechanistic
target
rapamycin
(PI3K/Akt/mTOR),
sirtuin
1/AMP-activated
protein
kinase/peroxisome
proliferator-activated
receptor-γ
coactivator-1α
(Sirt1/AMPK/PGC-1α),
transforming
growth
factor-β1/small
mothers
decapentaplegic
3
(TGF-β1/Smad3),
B/endothelial
nitric
oxide
synthase
(Akt/eNOS),
others.
Finally,
highlight
existing
problems
associated
with
need
be
addressed,
requirement
clinical
evidence
enhanced
bioavailability,
promising
drug
candidate.
Язык: Английский
Isoliquiritigenin Promotes the Repair of High Uric Acid‐Induced Vascular Injuries
Smart Medicine,
Год журнала:
2025,
Номер
4(2)
Опубликована: Апрель 4, 2025
ABSTRACT
Hyperuricemia
(HUA)
is
a
chronic
metabolic
disease
mainly
stemming
from
purine
metabolism
disorders
and
strongly
correlated
with
cardiovascular
diseases,
gout,
kidney
disease,
other
diseases.
Elevated
levels
of
uric
acid
(UA)
in
serum
will
lead
to
vascular
endothelial
cell
injuries
directly,
subsequently
impairing
normal
functions
human
blood
vessels.
Therefore,
investigating
resulting
HUA
corresponding
drug
screening
for
its
treatment
are
great
significance
the
prevention
Given
inherent
advantages
multiple
targets
pathways,
we
delved
into
potential
traditional
Chinese
medicine
alleviating
induced
by
detail.
Through
establishment
an
injury
index
library
subsequent
process,
isoliquiritigenin
proved
be
promising
candidate
promoting
repair
HUA‐induced
injuries.
It
had
been
identified,
validated
efficiency
evaluated
using
vessel‐on‐a‐chip
animal
tests.
Additionally,
network
pharmacology
molecular
docking
were
further
employed
elucidate
underlying
mechanism.
This
work
represents
first
demonstration
isoliquiritigenin's
capacity
facilitate
triggered
high
UA
levels,
provides
valuable
insights
medicine.
Язык: Английский