Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 7, 2024
The cardiometabolic disorders that surface during postmenopausal period are characterized by their common underlying pathophysiological mechanisms, specifically oxidative stress and inflammation [8]. Despite the extensive ongoing research in this area, knowledge gaps still remain our understanding of complex mechanisms drive estrogen deficiency, androgen excess menopause. To gain a deeper insight into complexity these regulatory further studies required to find novel biomarkers diagnostic prognostic significance, more comprehensive morbidities, ultimately improving patient care.The aim special issue was delve current trends, advancements, role women. invited topics mainly included early diagnosis menopause, potential linking stress, identification innovative associated with hormone replacement therapy as treatment option exploration therapeutic possibilities involving antioxidants different weight-loss programs for This published following four interesting original articles. Herein, we present an overview introduce readers key papers field.MAFLD has emerged challenging entity among prevalent liver diseases women at high risk developing particular morbidity [9], making intervention top priority field. aim, Yang et al. established new predictive nomogram model MAFLD using data from 942 which offers clinicians better tool mass screening based on its limited simple clinical laboratory indicators, without requiring procedures such biopsy, magnetic resonance imaging (MRI), computed tomography (CT) scan or other elaborate tests. identified 11 clinically accessible objective variables including occupation, body index, waist-to-hip ratio, number abortions, anxiety, hypertension, hyperlipidemia, diabetes, hyperuricemia, diet. Notably, there good agreement found between predicted probability actual incidence training (676 cases) validation (226 groups. Moreover, decision curve analysis (DCA) revealed had net benefit predicting can be conveniently adopted Consequently, those will need assessed through tests biochemical measurements implementation individualized plans.Osteoporosis is systemic skeletal disease bone fragility fractures not uncommon elderly men aged over 50 years [10]. factors include old age, insufficient vitamin D calcium intake, malnutrition, wight below 57 kg, smoking, primary hyperparathyroidism, glucocorticoid use 3 months, hypogonadism, menopause before 45 age [11]. Nutrition emerges one crucial involved osteoporosis rises globally. Given only evaluating effect dietary diversity osteoporosis, especially women, dire investigate link indicators nutrients adequacy diet quality end, Abbasi investigated relationship food group scores case control study diverse 378 Iranian 45-85 yrs. investigators reported inverse correlation fruits, vegetables, grains (bread cereal) while no significant dairy products meats specific population. Overall, would less vegetables increased. These findings may guide educational high-risk groups Nonetheless, randomized trials needed validate establish causal osteoporosis.Arterial stiffness enhances considered independent factor CVD [12], aging [13]. Carotid-femoral pulse wave velocity (cf-PWV) gold standard technique arterial stiffness; higher cf-PWV, lower vascular elasticity greater stiffness. However, cf-PWV could widely practice due largely requirements trained personnel specialized equipment. estimated (ePWV), calculated mean blood pressure indices, been suggested effective alternative cf-PWV. Speaking advanced being critical Klotho regarded anti-aging protein expressed renal distal convoluted tubules plays protective processes inflammation, aging. it remains unclear how levels might affect effect, Wang deciphered serum (ln-transformed) ePWV first crosssectional large cohort 4,468 (2,797 hypertensive 1,671 non-hypertensive). were significantly independently negatively correlated non-hypertensive non-Hispanic black ethnicity <60 yrs associations suggests elevated against whereas presence hypertension modulate relationship.Sex hormones sex differences related multiple sclerosis [14]; however, ratios metabolic inflammatory markers elusive. In addressing important scenario, Dubey conducted retrospective US adults (4,360 4,807 women) National Health Examination Survey cycles 2013-2016. authors showed elevations free estradiol index robustly positively C-reactive (CRP) all ages older (≥50 yrs). Interestingly, <50 yrs, rather CRP levels. While did change even after adjusting hormones. Lastly, thank contributors who enriched submitting manuscripts highlighting highly valuable studies.
Язык: Английский
