Evaluation of placental growth factor, Vitamin D, and systemic inflammatory index as predictive biomarkers for preeclampsia severity: a retrospective cohort study

BMC Pregnancy and Childbirth, Год журнала: 2025, Номер 25(1)

Опубликована: Янв. 27, 2025

Our study aimed to evaluate the predictive value of Placental growth factor (PlGF), Vitamin D, and systemic inflammatory index for assessing preeclampsia risk severity. This retrospective cohort included 457 pregnant individuals who delivered at our hospital between March 2023 October 2024. Participants were divided into three groups: control (n = 217), mild 101), severe 67). A separate validation 72) was used test model performance. Data on demographic, clinical, laboratory characteristics, including PlGF, neutrophil, lymphocyte, monocyte counts, collected 16 20 weeks gestation. Logistic regression analysis performed identify independent factors, receiver operating characteristic (ROC) curve assess power lymphocyte count, Pan-immune-inflammation (PIV). The models adjusted potential confounders, maternal age, body mass (BMI), parity. In training cohort, significant differences observed among control, mild, groups, with cases showing elevated PIV (515.8 ± 126.7) reduced levels PlGF (12.5 5.8 pg/mL) D (8.4 1.9 ng/mL) compared controls (P < 0.001). identified lower 0.001) as factors preeclampsia. also a strong predictor, high hazard ratio cohorts, ROC showed AUC values 0.774 0.751 0.805 0.796 0.688 0.675 Lymphocyte, 0.724 0.752 PIV, respectively, indicating in risk. Lower along higher independently associated an increased These findings suggest that are valuable biomarkers early identification high-risk patients, potentially aiding timely intervention improved outcomes.

Язык: Английский

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Research Progress on Immune Tolerance Therapy in Patients with Hemophilia A with Inhibitors

Advances in Clinical Medicine, Год журнала: 2025, Номер 15(04), С. 90 - 96

Опубликована: Янв. 1, 2025

Язык: Английский

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