Association between platelet to high-density lipoprotein cholesterol ratio (PHR) and hypertension: evidence from NHANES 2005–2018
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Окт. 26, 2024
The
Platelet
to
High-Density
Lipoprotein
cholesterol
Ratio
(PHR)
is
a
novel
indicator
of
inflammatory
response
and
metabolic
disorders,
linked
various
chronic
diseases.
This
study
aims
investigate
the
relationship
between
PHR
hypertension.
Data
from
National
Health
Nutrition
Examination
Survey
(NHANES),
collected
across
seven
consecutive
cycles
2005
2018,
were
analyzed.
dataset
included
participants'
hypertension
status
as
reported
by
doctor,
their
use
antihypertensive
medications,
average
three
blood
pressure
measurements
identify
hypertensive
adults,
along
with
complete
information
for
calculation.
was
calculated
based
on
(PLT)
count
(HDL-C)
using
following
formula:
=
[PLT
(1000
cells/µL)
/
HDL-C
(mmol/L)].
A
multivariable
logistic
regression
model
employed
assess
association
hypertension,
subgroup
analyses
conducted
explore
potential
influencing
factors.
Additionally,
Restricted
Cubic
Spline
(RCS)
curves
applied
threshold
effect
analysis
describe
nonlinear
relationships.
Higher
associated
an
increased
prevalence
After
adjusting
covariates,
including
race,
education
level,
Family
Poverty
Income
(PIR),
smoking,
alcohol
consumption,
sleep
disturbances,
waist
circumference,
diabetes,
coronary
heart
disease,
angina,
attack,
stroke,
results
remained
significant
(OR
1.36;
95%
CI,
1.32,
1.41,
P
<
0.001).
Participants
highest
levels
had
104%
higher
risk
compared
those
lowest
2.04;
1.89,
2.21,
Elevated
are
strongly
Specifically,
when
below
280,
increases
in
proportion
PHR.
suggests
that
regular
monitoring
may
help
patients
at
early,
allowing
timely
interventions
slow
disease
progression.
Larger
cohort
studies
necessary
confirm
these
findings.
Язык: Английский
Association of the Platelets to High Density Lipoprotein Cholesterol Ratio and Risk of Heart Disease Events in Middle-Aged and Elderly Chinese Population: A Retrospective Cohort Study Utilizing the CHARLS Database
Reviews in Cardiovascular Medicine,
Год журнала:
2025,
Номер
26(2)
Опубликована: Фев. 18, 2025
Background:
The
association
between
the
platelet
to
high-density
lipoprotein
cholesterol
ratio
(PHR)
and
risk
of
a
heart
disease
event
remains
unclear.
This
study
aims
determine
whether
PHR
can
identify
individuals
at
high
for
events,
with
particular
focus
on
middle-aged
elderly
Chinese
individuals.
Methods:
retrospective
cohort
encompassed
7188
participants
(>45
years)
sourced
from
China
Health
Retirement
Longitudinal
Study
(CHARLS)
database.
research
utilized
longitudinal
data
5
follow-up
visits
spanning
2011
2020,
which
collection
demographic
profiles
pertinent
blood
biomarkers.
Kaplan-Meier
survival
analysis
was
conducted
based
quartiles,
differences
assessed
using
log-rank
test.
Cox
proportional
hazards
model
evaluated
PHR’s
hazard
(HR)
as
predictor
outcome
trend
tests
applied.
Restrictive
cubic
splines
(RCS)
were
employed
explore
associations.
Subgroup
analyses
performed
validate
robustness
findings.
Results:
Baseline
comparisons
across
quartiles
revealed
progressive
increase
in
values
(133.16
vs
202.09
267.04
388.24),
corresponded
ascending
incidence
rates
(18.20%
18.64%
18.86%
21.59%)
(p
<
0.05).
quartile
groups
notable
elevation
cardiovascular
events
Q4
compared
Q1,
Q2,
Q3
throughout
period
(log-rank
p
Upon
adjustment
age,
gender,
stroke
history,
drinking,
smoking,
body
mass
index
(BMI),
white
cell
(WBC)
count,
fasting
plasma
glucose
(FPG),
creatinine
(Cr),
triglyceride
(TG),
group
continued
exhibit
significantly
elevated
HR
relative
Q1
(HR
=
1.203,
0.023).
Furthermore,
RCS
affirmed
linear
(Adjusted:
Overall
0.014,
Nonlinear
0.588).
When
analyzing
by
factor
males
(Q4:
1.352,
0.019),
but
not
females
1.158,
0.166).
indicates
significant
higher
levels
increased
cardiac
lower
levels.
Conclusions:
Our
reveals
positive
correlation
men
China.
However,
no
such
observed
female
patients.
Язык: Английский
The association between uric acid to high-density cholesterol ratio and depression: A population-based cross-sectional study
Journal of Affective Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Association of neutrophil to lymphocyte ratio with all-cause and cardiovascular mortality among individuals with kidney stone disease: result from NHANES, 2007-2018
Qihui Chu,
Bin Wu,
Zhaofu Zhang
и другие.
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
16
Опубликована: Март 14, 2025
The
objective
of
this
study
is
to
investigate
the
relationship
between
neutrophil-to-lymphocyte
ratio
(NLR)
and
all-cause
as
well
cause-specific
mortality
among
patients
with
kidney
stones,
evaluate
capability
NLR
a
predictor
mortality.
This
included
2,995
stones
from
NHANES
database
during
period
2007
2018,
subsequently
linked
data
National
Death
Index.
was
analyzed
using
Cox
proportional
hazards
model
Kaplan-Meier
survival
curves.
Additionally,
restricted
cubic
spline
(RCS)
curves
were
employed
explore
dose-response
mortality,
while
time-dependent
ROC
utilized
assess
predictive
for
Finally,
mediating
effect
estimated
glomerular
filtration
rate
(eGFR)
on
also
analyzed.
ultimately
median
follow-up
74
months.
A
total
395
deaths
recorded,
which
87
attributed
cardiovascular
diseases.
An
cut-off
3.62
identified
significantly
associated
outcomes
'maxstat'
package
principle
maximum
rank
statistics.
plot
indicates
non-linear
both
After
adjusting
relevant
covariates,
regression
analysis
demonstrated
that,
in
comparison
lower
group,
higher
group
exhibited
1.05-fold
(HR
2.05,
95%
CI
1.51-2.78,
P
<
0.001)
increased
risk
1.99-fold
2.99,
1.89-4.72,
Furthermore,
eGFR
significant
found
that
exhibiting
high
have
U.S.
population.
Therefore,
monitoring
may
be
important
prognosis
stones.
Язык: Английский
Association between RAR and the prevalence and prognosis of depression: A population-based study
Journal of Affective Disorders,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Association fasting blood sugar to high-density lipoprotein cholesterol ratio and hypertension: Analysis from the National Health and Nutrition Examination Survey (2003– 2018)
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 29, 2025
Abstract
Hypertension
is
a
chronic
disease
that
poses
significant
threat
to
human
health
worldwide.
The
ratio
of
fasting
blood
sugar
high-density
lipoprotein
cholesterol
(GHR)
an
emerging
biomarker
associated
with
various
diseases.
However,
the
relationship
between
GHR
and
hypertension
was
still
unclear.
This
study
aimed
explore
correlation
high
pressure.
conducted
comprehensive
cross-sectional
analysis
based
on
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2003
2018.
used
multivariate
logistic
regression
model
evaluate
hypertension.
It
also
verified
robustness
results
through
subgroup
analysis.
In
addition,
restricted
cubic
splines
(RCS)
analyze
possible
nonlinear
hypertension,
as
well
potential
threshold
effects.
Finally,
evaluated
predictive
efficiency
for
receiver
operating
characteristic
(ROC)
curve
showed
that,
without
adjusting
confounding
factors,
positively
correlated
(OR
=
1.20,
95%CI
1.17–1.22,
P
<
0.001).
After
fully
factors
(including
gender,
race,
age,
body
mass
index,
smoking
status,
alcohol
consumption,
diabetes,
stroke,
total
cholesterol,
creatinine),
positive
existed
1.06,
1.03–1.09,
Subgroup
further
association
remained
consistent
across
different
subgroups.
ROC
revealed
turning
point
2.36.
Furthermore,
indicated
demonstrated
in
univariate
multivariate-adjusted
models.
A
had
serve
biological
marker
facilitating
its
prevention
diagnosis.
Язык: Английский
Association of platelet-to-HDL cholesterol ratio with frailty and all-cause mortality
Lipids in Health and Disease,
Год журнала:
2024,
Номер
23(1)
Опубликована: Окт. 23, 2024
Frailty
often
requires
intensive
care,
and
the
admission
outcomes
of
frail
patients
are
poor.
However,
owing
to
lack
reliable
diagnostic
indicators,
quickly
identifying
frailty
is
challenging.
The
present
study
aimed
explore
associations
platelet/high-density
lipoprotein
cholesterol
ratio
(PHR;
a
novel
inflammatory
indicator)
with
all-cause
mortality.
analyzed
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005
2018.
was
assessed
on
basis
49-item
Index.
PHR
long-term
survival
prognosis
were
explored
through
weighted
logistic
regression,
restricted
cubic
spline
(RCS),
Cox
adjustments
for
demographic
factors,
lifestyle,
blood
lipids,
medication
history,
complications.
In
addition,
subgroup
interaction
analyses
conducted.
Finally,
several
sensitivity
performed.
A
total
15,615
adult
participants
included,
7,928
women
(53.63%)
an
average
age
60.76
years.
After
fully
adjusting
confounding
variables,
prevalence
in
highest
quartile
group
significantly
greater
than
that
lowest
(OR:
1.23,
95%
CI:
1.04–1.47;
P
=
0.02).
RCS
showed
inflection
point
166.7.
Before
after
point,
negatively
associated
0.88,
0.80–0.97,
0.01)
positively
1.10,
1.02–1.19,
frailty,
respectively.
Subgroup
analysis
suggested
association
between
stronger
men.
5,544
included
analysis.
revealed
mortality
risk
U-shaped
manner,
240.4.
decreased
(HR:
0.89,
0.81–0.97,
increased
1.08,
1.02–1.14,
0.01),
suggests
there
J-shaped
population
United
States
women.
has
relationship
patients.
Язык: Английский
Association between platelet-to-high-density lipoprotein cholesterol ratio and future stroke risk: a national cohort study based on CHARLS
Frontiers in Neurology,
Год журнала:
2024,
Номер
15
Опубликована: Ноя. 13, 2024
Background
According
to
recent
research,
there
is
a
considerable
correlation
between
the
severity
of
coronary
artery
disease
and
platelet-to-high-density
lipoprotein
cholesterol
ratio
(PHR),
which
suggests
that
PHR
potentially
valuable
inflammatory
biomarker.
However,
body
current
research
offers
insufficiently
strong
evidence
clarify
connection
incidence
stroke.
Therefore,
this
study
aims
elucidate
any
potential
associations
stroke
risk.
Methods
This
employed
data
from
China
Health
Retirement
Longitudinal
Study
(CHARLS)
covering
period
2011
2018.
It
included
5,872
participants
who
did
not
have
history
in
2011.
These
patients
were
separated
into
four
groups
according
their
baseline
quartiles.
The
main
goal
was
focus
on
outcomes.
Stroke
defined
as
an
occurrence
cerebrovascular
accident
confirmed
by
physician.
We
Cox
proportional
hazards
regression
models
investigate
association
likelihood
experiencing
Furthermore,
we
conducted
restricted
cubic
spline
analysis
subgroup
analysis.
Results
average
follow-up
77.5
months,
during
390
experienced
In
comparison
lowest
quartile
group,
highest
had
49%
increased
risk
(HR
1.49,
95%
CI
1.13–1.96,
p
=
0.004).
adjusted
multivariable
maintained
statistical
significance
(aHR
1.42,
1.06–1.90,
0.019).
After
adjustment,
positive
linear
relationship
identified
through
(nonlinear
>
0.05).
Additionally,
impact
consistent
across
variety
subgroups,
evidenced
Conclusion
Our
indicates
higher
levels
are
significantly
associated
with
these
can
be
used
identify
at
high
Язык: Английский