Dual disease co-expression analysis reveals potential roles of estrogen-related genes in postmenopausal osteoporosis and Parkinson’s disease
Frontiers in Genetics,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 7, 2025
The
deficiency
of
estrogen
correlates
with
a
range
diseases,
notably
Postmenopausal
osteoporosis
(PMO)
and
Parkinson's
disease
(PD).
There
is
possibility
that
PMO
PD
may
share
underlying
molecular
mechanisms
are
pivotal
in
their
development
progression.
objective
this
study
was
to
identify
critical
genes
potential
associated
by
examining
co-expressed
linked
PD.
Initially,
pertinent
data
concerning
were
obtained
from
the
GWAS
database,
followed
conducting
Bayesian
colocalization
analysis.
Subsequently,
dataset
(GSE35956)
(GSE20164)
identified
cross-referenced
estrogen-related
(ERGs).
Differentially
expressed
(DEGs)
among
PMO,
PD,
ERGs
subjected
an
array
bioinformatics
analyses,
including
Kyoto
Encyclopedia
Genes
Genomes
(KEGG)
Gene
Ontology
(GO)
enrichment
addition
protein-protein
interaction
(PPI)
network
also
involved
constructing
TF-gene
interactions,
TF-microRNA
coregulatory
networks,
interactions
hub
validation
through
quantitative
reverse
transcription
polymerase
chain
reaction
(qRT-PCR).
analysis
uncovered
shared
genetic
variants
between
osteoporosis,
posterior
probability
(PPH4)
measured
at
0.967.
Notably,
rs3796661
recognized
as
variant.
A
total
11
classified
DEGs
across
ERGs.
Five
principal
KEGG
pathways
identified,
which
include
p53
signaling
pathway,
TGF-beta
cell
cycle,
FoxO
cellular
senescence.
Additionally,
three
genes-WT1,
CCNB1,
SMAD7-were
selected
PPI
utilizing
Cytoscape
software.
These
genes,
possess
significant
diagnostic
value
for
further
validated
using
GEO
datasets.
Interactions
factors
well
microRNAs
established.
Ultimately,
expression
trends
confirmed
qRT-PCR
validation.
This
anticipated
offer
innovative
approaches
identifying
biomarkers
important
therapeutic
targets
both
Язык: Английский
Gut-disc axis: A Mendelian randomization study on the relationship between gut microbiota and cervical spondylosis
Jiling Zhang,
Baodong Wang,
Peng Du
и другие.
Medicine,
Год журнала:
2025,
Номер
104(7), С. e41536 - e41536
Опубликована: Фев. 14, 2025
The
gut-disc
axis,
which
refers
to
the
interaction
between
gut
microbiota
and
bone
health,
has
recently
garnered
widespread
attention
in
scientific
community.
However,
it
remains
be
determined
whether
directly
induces
cervical
spondylosis
(CS).
This
study
employed
a
bidirectional
2-sample
Mendelian
randomization
(MR)
analysis
explore
potential
causal
link
CS.
We
initially
used
inverse
variance
weighted
method
for
preliminary
estimation
supplemented
with
other
MR
methods,
including
MR-Egger,
median,
mode,
simple
mode.
Furthermore,
we
utilized
Cochrane
Q
test,
MR-PRESSO
global
MR-Egger
intercept
test
assess
possible
pleiotropy
heterogeneity.
Ultimately,
conducted
investigate
reverse
associations
identified
27
significantly
associated
CS,
of
12
may
contributing
factors,
while
15
have
protective
effects.
further
revealed
relationship
CS
24
microbiota.
In
this
study,
no
significant
heterogeneity
or
was
detected.
Through
analysis,
uncovered
providing
new
perspectives
prevention
treatment
especially
modulation
Язык: Английский
Cross-talks between osteoporosis and gut microbiome
World Journal of Orthopedics,
Год журнала:
2025,
Номер
16(3)
Опубликована: Март 12, 2025
Язык: Английский
Mechanisms of gut homeostasis regulating Th17/Treg cell balance in PMOP
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 13, 2024
Postmenopausal
osteoporosis
(PMOP)
is
a
metabolic
bone
disease
driven
by
estrogen
deficiency,
primarily
manifesting
as
reduced
mass
and
heightened
fracture
risk.
Its
development
intricately
linked
to
the
balance
between
Th17
Treg
cells.
Recent
studies
have
highlighted
significant
role
of
gut
homeostasis
in
PMOP.
The
microbiota
profoundly
impacts
health
modulating
host’s
immune
system,
pathways,
endocrine
functions.
In
particular,
regulation
cell
plays
pivotal
onset
progression
cells
secrete
pro-inflammatory
cytokines
that
stimulate
osteoclast
activity,
accelerating
resorption,
while
counteract
this
process
through
anti-inflammatory
mechanisms,
preserving
mass.
its
metabolites
can
influence
Th17/Treg
equilibrium,
thereby
metabolism.
Furthermore,
integrity
barrier
critical
for
systemic
stability,
disruption
lead
dysregulation
imbalances.
Thus,
targeting
restore
offers
novel
therapeutic
avenue
prevention
treatment
Язык: Английский
Skin Disorders and Osteoporosis: Unraveling the Interplay Between Vitamin D, Microbiota, and Epigenetics Within the Skin–Bone Axis
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
26(1), С. 179 - 179
Опубликована: Дек. 28, 2024
Growing
scientific
evidence
suggests
a
strong
interconnection
between
inflammatory
skin
diseases
and
osteoporosis
(OP),
systemic
condition
characterized
by
decreased
bone
density
structural
fragility.
These
conditions
seem
to
share
common
pathophysiological
mechanisms,
including
immune
dysregulation,
chronic
inflammation,
vitamin
D
deficiency,
which
play
crucial
role
in
both
health.
Additionally,
the
roles
of
gut
microbiota
(GM)
epigenetic
regulation
via
microRNAs
(miRNAs)
emerge
as
key
elements
influencing
progression
conditions.
This
review
aims
examine
skin–bone
axis,
exploring
how
factors
such
D,
GM,
miRNAs
interact
subtle
interplay
driving
inflammation
immune-metabolic
alterations.
Recent
research
that
combined
therapeutic
approaches—including
supplementation,
targeted
interventions,
miRNA-based
therapies—could
be
promising
strategies
for
managing
comorbid
OP.
perspective
highlights
need
multidisciplinary
approaches
clinical
management
related
skin-bone
axis.
Язык: Английский