Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis DOI

Jia-Ting Li,

Dian Ou,

Yi‐Ming Shi

и другие.

Brain Injury, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Апрель 16, 2025

Cells universally employ an efficiency-driven metabolic switch mechanism during nutritional changes, growth, and differentiation, transitioning from oxidative phosphorylation (OXPHOS) to glycolysis ensure survival under hypoxic conditions or high energy demands. In cerebral ischemia, inadequate blood supply causes oxygen deprivation, prompting brain cells initiate glycolytic reprogramming meet urgent needs. While this adaptation is a temporary solution, it may lead lactic acidosis, aggravated inflammation, increased free radical production. Prolonged reperfusion with sustained can exacerbate cell damage, potentially causing irreversible harm. This review systematically examines the dynamic changes in glucose transport mechanisms roles of immediate, early, intermediate, late responder cells, along their regulatory factors, reprogramming. Using temporal analysis framework based on body's natural response sequence pathological events, we elucidate how at different stages collaborate address metabolism conditions. Reversing inhibiting improve processes ischemic stroke, offering potential therapeutic benefits.

Язык: Английский

Risk Factors and Prediction Model for Post-operative Cognitive Dysfunction After Aneurysmal Subarachnoid Hemorrhage DOI Creative Commons

Zhu Lan,

Yanli Ma, Yingying Peng

и другие.

Current Problems in Surgery, Год журнала: 2025, Номер unknown, С. 101767 - 101767

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Post-cerebral ischemia energy crisis: the role of glucose metabolism in the energetic crisis DOI

Jia-Ting Li,

Dian Ou,

Yi‐Ming Shi

и другие.

Brain Injury, Год журнала: 2025, Номер unknown, С. 1 - 11

Опубликована: Апрель 16, 2025

Cells universally employ an efficiency-driven metabolic switch mechanism during nutritional changes, growth, and differentiation, transitioning from oxidative phosphorylation (OXPHOS) to glycolysis ensure survival under hypoxic conditions or high energy demands. In cerebral ischemia, inadequate blood supply causes oxygen deprivation, prompting brain cells initiate glycolytic reprogramming meet urgent needs. While this adaptation is a temporary solution, it may lead lactic acidosis, aggravated inflammation, increased free radical production. Prolonged reperfusion with sustained can exacerbate cell damage, potentially causing irreversible harm. This review systematically examines the dynamic changes in glucose transport mechanisms roles of immediate, early, intermediate, late responder cells, along their regulatory factors, reprogramming. Using temporal analysis framework based on body's natural response sequence pathological events, we elucidate how at different stages collaborate address metabolism conditions. Reversing inhibiting improve processes ischemic stroke, offering potential therapeutic benefits.

Язык: Английский

Процитировано

0