Frontiers in Genetics,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 23, 2023
Introduction:
Abdominal
aortic
aneurysms
(AAA)
are
among
the
most
lethal
non-cancerous
diseases.
A
comprehensive
analysis
of
AAA-related
disease
model
has
yet
to
be
conducted.
Methods:
Weighted
correlation
network
(WGCNA)
was
performed
for
genes.
Machine
learning
random
forest
and
LASSO
regression
were
develop
score.
Immune
characteristics
epigenetic
score
explored.
Results:
Our
study
developed
a
reliable
predicting
immunity
m1A/m5C/m6A/m7G
regulation.
Discussion:
The
pathogenic
roles
four
genes,
UBE2K,
TMEM230,
VAMP7,
PUM2,
in
AAA,
need
further
validation
by
vitro
vivo
experiments.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Авг. 31, 2024
This
study
investigates
the
molecular
mechanisms
of
CC@AC&SF@PP
NPs
loaded
with
AC099850.3
siRNA
and
sorafenib
(SF)
for
improving
hepatitis
B
virus-related
hepatocellular
carcinoma
(HBV-HCC).
A
dataset
44
HBV-HCC
patients
their
survival
information
was
selected
from
TCGA
database.
Immune
genes
related
to
status
were
identified
using
ImmPort
database
WGCNA
analysis.
prognostic
risk
model
constructed
analyzed
Lasso
regression.
Differential
analysis
performed
screen
key
genes,
significance
predictive
accuracy
validated
Kaplan–Meier
curves,
ROC
analysis,
CIBERSORT
correlation
The
between
gene
expression
matrix
calculated,
followed
by
GO
KEGG
enrichment
its
co-expressed
genes.
HepG2.2.15
cells
in
vitro
validation,
lentivirus
interference,
cell
cycle
determination,
CCK-8
experiments,
colony
formation
assays,
Transwell
scratch
flow
cytometry
investigate
effects
on
cells.
subcutaneous
transplanted
tumor
mice
verify
inhibitory
effect
tumors.
Subsequently,
pH-triggered
drug
release
(CC@AC&SF@PP)
prepared,
therapeutic
situ
studied.
(AC012313.9,
MIR210HG,
AC099850.3,
AL645933.2,
C6orf223,
GDF10)
through
bioinformatics
showing
good
sensitivity
specificity
diagnostic
prediction.
as
a
gene,
revealed
impact
pathways.
In
experiments
demonstrated
that
promotes
proliferation
invasion
regulating
immune
checkpoint
CD276
progression.
vivo,
subcutaneously
showed
growth
tumors
nude
mice.
Furthermore,
SF
successfully
prepared
delivered
HBV-HCC,
enhancing
effectiveness
combined
therapy
HBV-HCC.
accelerates
progression
occurrence
development
upregulating
expression.
improve
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(16), С. 9272 - 9272
Опубликована: Авг. 17, 2022
This
review
is
devoted
to
changes
in
the
post-transcriptional
maturation
of
RNA
human
glioblastoma
cells,
which
leads
disruption
normal
course
apoptosis
them.
The
thoroughly
highlights
latest
information
on
both
modifications
certain
regulatory
RNAs,
associated
with
process
apoptosis,
presents
data
features
and
shows
relationship
between
RNAs
tumor
cells.
In
conclusion,
potential
target
candidates
are
presented
that
necessary
for
development
new
drugs
treatment
glioblastoma.
Frontiers in Pharmacology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 30, 2022
Cervical
cancer
(CC)
is
the
fourth
leading
gynecological
malignancy
in
females
worldwide.
Cuproptosis,
a
form
of
cell
death
induced
by
copper,
elicits
novel
therapeutic
strategy
anticancer
therapy.
Nonetheless,
effects
cuproptosis-related
lncRNAs
CC
remain
unclear.
Therefore,
we
aim
to
investigate
lncRNAs,
develop
risk
model
for
prognostic
prediction,
and
elucidate
immunological
profile
CC.
Transcription
profiles
clinical
follow-up
data
were
retrieved
from
The
Cancer
Genome
Atlas
(TCGA)
database.
Afterward,
was
built
distinguishing
using
least
absolute
shrinkage
selection
operator
(LASSO)
Cox
regression.
correctness
validated,
nomogram
established
followed
tumor
immune
microenvironment
analysis.
Tumor
dysfunction
exclusion
(TIDE)
scores
used
assess
immunotherapy
response,
pharmaceutical
half-maximal
inhibitory
concentration
(IC50)
prediction
performed
potential
chemotherapy
medicines.
Finally,
through
coexpression
analysis,
199
collected.
A
unique
generated
6
selected
lncRNAs.
score
reliable
independent
survival
with
higher
diagnostic
effectiveness
compared
generic
characteristics.
Immunological
infiltration
investigation
indicated
that
substantially
linked
patients’
immunology,
low-risk
patients
had
lower
TIDE
increased
checkpoint
expression,
suggesting
stronger
response.
Besides,
high-risk
group
exhibited
distinct
sensitivity
medications.
immune-related
progression
connected
differentially
expressed
genes
(DEGs)
between
groups.
Generally,
comprised
may
help
predict
overall
survival,
indicate
immunocyte
infiltration,
identify
individualized
treatment.
Cancers,
Год журнала:
2023,
Номер
15(4), С. 1232 - 1232
Опубликована: Фев. 15, 2023
RNA
modifications
are
diverse,
dynamic,
and
reversible
transcript
alterations
rapidly
gaining
attention
due
to
their
newly
defined
regulatory
roles
in
cellular
pathways
pathogenic
mechanisms.
The
exciting
emerging
field
of
‘epitranscriptomics’
is
predominantly
centred
on
studying
the
most
abundant
mRNA
modification,
N6-methyladenine
(m6A).
m6A
mark,
similar
many
other
modifications,
strictly
regulated
by
so-called
‘writer’,
‘reader’,
‘eraser’
protein
species.
abundance
genes
coding
for
expression
these
regulator
proteins
levels
shows
great
potential
as
diagnostic
predictive
tools
across
several
cancer
fields.
This
review
explores
our
current
understanding
glioma
biology
epitranscriptomics
develop
new
classification
that
can
stratify
highly
complex
heterogeneous
brain
tumours.
Frontiers in Genetics,
Год журнала:
2023,
Номер
14
Опубликована: Фев. 23, 2023
Introduction:
Abdominal
aortic
aneurysms
(AAA)
are
among
the
most
lethal
non-cancerous
diseases.
A
comprehensive
analysis
of
AAA-related
disease
model
has
yet
to
be
conducted.
Methods:
Weighted
correlation
network
(WGCNA)
was
performed
for
genes.
Machine
learning
random
forest
and
LASSO
regression
were
develop
score.
Immune
characteristics
epigenetic
score
explored.
Results:
Our
study
developed
a
reliable
predicting
immunity
m1A/m5C/m6A/m7G
regulation.
Discussion:
The
pathogenic
roles
four
genes,
UBE2K,
TMEM230,
VAMP7,
PUM2,
in
AAA,
need
further
validation
by
vitro
vivo
experiments.
