Targeting Ferroptosis in Bone-Related Diseases: Facts and Perspectives
Journal of Inflammation Research,
Год журнала:
2023,
Номер
Volume 16, С. 4661 - 4677
Опубликована: Окт. 1, 2023
Abstract:
Ferroptosis
is
a
new
cell
fate
decision
discovered
in
recent
years.
Unlike
apoptosis,
autophagy
or
pyroptosis,
ferroptosis
characterized
by
iron-dependent
lipid
peroxidation
and
mitochondrial
morphological
changes.
involved
variety
of
physiological
pathological
processes.
Since
its
discovery,
has
been
increasingly
studied
concerning
bone-related
diseases.
In
this
review,
we
focus
on
the
latest
research
progress
prospects,
summarize
regulatory
mechanisms
ferroptosis,
discuss
role
pathogenesis
diseases,
such
as
osteoporosis
(OP),
osteoarthritis
(OA),
rheumatoid
arthritis
(RA),
osteosarcoma
(OS),
well
therapeutic
potential.
Keywords:
death,
iron
accumulation,
peroxidation,
diseases
Язык: Английский
Baicalin protects against hepatocyte injury caused by aflatoxin B1 via the TP53-related ferroptosis Pathway
H. Zhang,
Jian-Zhu Luo,
Chenlu Lan
и другие.
Ecotoxicology and Environmental Safety,
Год журнала:
2024,
Номер
281, С. 116661 - 116661
Опубликована: Июль 1, 2024
Baicalin
has
antioxidative,
antiviral,
and
anti-inflammatory
properties.
However,
its
ability
to
alleviate
oxidative
stress
(OS)
DNA
damage
in
liver
cells
exposed
aflatoxin
B1
(AFB1),
a
highly
hepatotoxic
compound,
remains
uncertain.
In
this
study,
the
protective
effects
of
baicalin
on
AFB1-induced
hepatocyte
injury
mechanisms
underlying
those
were
investigated.
Stable
cell
lines
expressing
CYP3A4
established
using
lentiviral
vectors
assess
levels
by
conducting
assays
determine
content
reactive
oxygen
species
(ROS),
malondialdehyde
(MDA),
superoxide
dismutase
(SOD).
Additionally,
was
evaluated
8-hydroxy-2-deoxyguanosine
(8-OHdG)
comet
assays.
Transcriptome
sequencing,
molecular
docking,
vitro
experiments
conducted
injury.
vivo,
rat
model
induced
AFB1
used
evaluate
baicalin.
vitro,
significantly
attenuated
caused
due
OS,
as
determined
decrease
ROS,
MDA,
SOD
levels.
also
considerably
decreased
hepatocytes.
This
effect
found
be
closely
associated
with
TP53-mediated
ferroptosis
pathway.
To
elaborate,
physically
interacts
P53,
leading
suppression
expression
GPX4
SLC7A11,
which
turn
inhibits
ferroptosis.
vivo
findings
showed
that
AFB1-treated
tissues,
γ-H2AX
an
increase
SLC7A11
Overexpression
TP53
weakened
can
OS
via
theoretical
foundation
for
use
protecting
from
toxic
AFB1.
Язык: Английский
Translational Potential of Baicalein in Mitigating RSL3-Induced Ferroptosis in Fibroblasts: Implications for Therapeutic Interventions
Pao‐Jen Kuo,
Cheng‐Shyuan Rau,
Yi-Chan Wu
и другие.
International Journal of Medical Sciences,
Год журнала:
2024,
Номер
21(7), С. 1257 - 1264
Опубликована: Янв. 1, 2024
Ferroptosis
is
an
iron-driven
cell-death
mechanism
that
plays
a
central
role
in
various
diseases.
Recent
studies
have
suggested
baicalein
inhibits
ferroptosis,
making
it
promising
therapeutic
candidate.
Язык: Английский
Decoding ferroptosis: transforming orthopedic disease management
Guochen Huo,
Yumeng Lin,
Lusheng Liu
и другие.
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 6, 2024
As
a
mechanism
of
cell
death,
ferroptosis
has
gained
popularity
since
2012.
The
process
is
distinguished
by
iron
toxicity
and
phospholipid
accumulation,
in
contrast
to
autophagy,
apoptosis,
other
death
mechanisms.
It
implicated
the
advancement
multiple
diseases
across
body.
Researchers
currently
know
that
osteosarcoma,
osteoporosis,
orthopedic
disorders
are
caused
NRF2,
GPX4,
star
proteins.
effective
relief
osteoarthritis
symptoms
from
deterioration
been
confirmed
clinical
treatment
with
inhibitors.
At
same
time,
it
should
be
reminded
mechanisms
involved
regulate
not
understood.
In
this
manuscript,
we
present
discovery
ferroptosis,
role
variety
diseases.
We
expect
manuscript
can
provide
new
perspective
on
diagnosis
related
Язык: Английский
E2F-1 inhibits ferroptosis in osteosarcoma cells by activating the PSAT1/Xct/GPX4 signaling axis
Research Square (Research Square),
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 7, 2024
Abstract
Osteosarcoma
is
a
common
primary
malignant
bone
tumour
that
occurs
mainly
in
children
and
adolescents
has
poor
survival
prognosis.
Currently,
ferroptosis
newly
defined
form
of
cell
death,
but
the
mechanism
between
it
osteosarcoma
unclear.
To
further
investigate
relationship
ferroptosis,
important
to
search
for
new
biomolecular
factors.
We
used
bioinformatics
dig
deeper
into
gene
PSAT1,
which
closely
associated
with
osteosarcoma.
Although
PSAT1
been
reported
other
types
tumours
plays
an
role
development
many
tumours,
such
as
melanoma
breast
cancer,
little
research
done
field
explore
its
association
we
designed
relevant
experiments.
Subsequently,
predicted
transcription
factor
E2F-1
from
frediction
database
experimentally
verified
could
inhibit
OS
cells
by
activating
PSAT1.
The
results
indicated
promote
process
cells.
This
finding
implies
may
become
target
diagnosis
treatment
future,
bringing
breakthroughs
clinical
practice.
Язык: Английский