International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142798 - 142798
Опубликована: Апрель 1, 2025
Язык: Английский
Sustainability, Год журнала: 2025, Номер 17(3), С. 1250 - 1250
Опубликована: Фев. 4, 2025
Nanoparticle technology has emerged as a fundamental component across various industries, including electronics, renewable energy, textiles, and medical biotechnology, particularly for targeted drug delivery applications. Commercialization profoundly impacted economic growth, especially in the pharmaceutical electronics industries. Moreover, it improved workforce education training, generating millions of employment prospects associated with nanotechnology development. By 2024, Organisation Economic Co-operation Development anticipates that global market products will attain value United States Dollar (USD) 1 trillion to USD 3 trillion, resulting creation over 2 million new employments globally. The swift progression nanoparticle from 2000 2024 is primarily propelled by substantial industrial investment research development, alongside collaborations academic institutions. National Nanotechnology Initiative (US) significantly contributed these developments, federal funding exceeding 30 billion since its establishment 2001. This catalyzed significant advancements both commercial applications nanotechnology. Patent data highlights this expansion, China establishing itself preeminent nation patents. From steadily raised proportion patents, accounting almost 40% total 2024. US, Japan, Germany, Republic Korea continued be contributors, together advancing frontiers innovation In timeframe, quantity nanotechnology-related patents increased more than 150%, demonstrating growth sector. regulation US managed Food Drug Administration, about healthcare biotechnology As scope uses expanded, there an increasing demand extensive regulations concerning potential long-term environmental health effects. future trajectory nanotechnology, worldwide, hinge on continuous invention, advancement, governmental policy. upholding robust regulatory framework promoting ongoing collaboration between academics industry, complete societal progress can actualized.
Язык: Английский
Процитировано
3
Journal of Drug Delivery Science and Technology, Год журнала: 2023, Номер 91, С. 105157 - 105157
Опубликована: Ноя. 10, 2023
Язык: Английский
Процитировано
28
Pharmaceutics, Год журнала: 2023, Номер 15(11), С. 2623 - 2623
Опубликована: Ноя. 14, 2023
Biomimetic delivery systems (BDSs), inspired by the intricate designs of biological systems, have emerged as a groundbreaking paradigm in nanomedicine, offering unparalleled advantages therapeutic delivery. These encompassing platforms such liposomes, protein-based nanoparticles, extracellular vesicles, and polysaccharides, are lauded for their targeted delivery, minimized side effects, enhanced outcomes. However, translation BDSs from research settings to clinical applications is fraught with challenges, including reproducibility concerns, physiological stability, rigorous efficacy safety evaluations. Furthermore, innovative nature demands reevaluation evolution existing regulatory ethical frameworks. This review provides an overview delves into multifaceted translational challenges present emerging solutions, underscored real-world case studies. Emphasizing potential redefine healthcare, we advocate sustained interdisciplinary collaboration research. As our understanding deepens, future appears promising, focus on personalized medicine refined patient-specific systems.
Язык: Английский
Процитировано
19
Deleted Journal, Год журнала: 2024, Номер 5(2), С. 200139 - 200139
Опубликована: Апрель 10, 2024
Phytochemicals encompass a diverse array of bioactive substances originating from plants, exhibiting broad spectrum possible health-promoting effects. Nonetheless, the clinical uses these compounds are restricted due to their limited solubility, stability, bioavailability, and target selectivity. Nanotechnology-based delivery methods present viable approach address problems enhance properties biological activity phytochemicals. Nanoformulations have potential augment pharmacokinetics phytochemicals by means several methods. One surface area solubility is lowering particle size. The process adsorption surfactants onto phytochemical particles can lead formation micelles, which exhibit in water. uptake across many barriers, including intestinal epithelium. To study nanoformulation enhancing therapeutic action Performed systemic review while considering PRISM guidelines. nanoparticles great delivering could help management various diseases. Although, exhaustive research trials yet demanded provide evidential proof for same. In conclusion, utilisation ligand-functionalized enables precise targeting particular cells or tissues. field nanotechnology has significant promise transforming advancement administration medicinal preventative applications. holds addressing obstacles related physicochemical characteristics phytochemicals, hence enabling development enhanced systems advantageous molecules.
Язык: Английский
Процитировано
7
Experimental Hematology and Oncology, Год журнала: 2024, Номер 13(1)
Опубликована: Май 25, 2024
Abstract Hematological malignancies (HMs) encompass a diverse group of blood neoplasms with significant morbidity and mortality. Immunotherapy has emerged as validated crucial treatment modality for patients HMs. Despite notable advancements having been made in understanding implementing immunotherapy HMs over the past decade, several challenges persist. These include immune-related adverse effects, precise biodistribution elimination therapeutic antigens vivo, immune tolerance tumors, evasion by tumor cells within microenvironment (TME). Nanotechnology, its capacity to manipulate material properties at nanometer scale, potential tackle these obstacles revolutionize outcomes improving various aspects such drug targeting stability. The convergence nanotechnology given rise nano-immunotherapy, specialized branch anti-tumor therapy. Nanotechnology found applications chimeric antigen receptor T cell (CAR-T) therapy, cancer vaccines, checkpoint inhibitors, other immunotherapeutic strategies In this review, we delineate recent developments discuss current field nano-immunotherapy HMs, offering novel insights into nanotechnology-based approaches diseases.
Язык: Английский
Процитировано
7
Advanced technologies and societal change, Год журнала: 2024, Номер unknown, С. 1 - 64
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
7
Epigenetics & Chromatin, Год журнала: 2024, Номер 17(1)
Опубликована: Окт. 16, 2024
Cancer has arisen from both genetic mutations and epigenetic changes, making epigenetics a crucial area of research for innovative cancer prevention treatment strategies. This dual perspective propelled into the forefront research. review highlights important roles DNA methylation, histone modifications non-coding RNAs (ncRNAs), particularly microRNAs (miRNAs) long RNAs, which are key regulators cancer-related gene expression. It explores potential epigenetic-based therapies to revolutionize patient outcomes by selectively modulating specific markers involved in tumorigenesis. The examines promising biomarkers early detection prognosis. also recent progress oligonucleotide-based therapies, including antisense oligonucleotides (ASOs) antimiRs, precisely modulate processes. Furthermore, concept editing is discussed, providing insight future role precision medicine patients. integration nanomedicine therapy been explored offers approaches improve therapeutic efficacy. comprehensive advances seeks advance field oncology, ultimately culminating improved fight against cancer.
Язык: Английский
Процитировано
7
International Journal of Molecular Sciences, Год журнала: 2023, Номер 25(1), С. 296 - 296
Опубликована: Дек. 25, 2023
Hyperthermia has the potential to damage cancerous tissue by increasing body temperature. However, targeting cancer cells whilst protecting surrounding tissues is often challenging, especially when implemented in clinical practice. In this direction, there are data showing that combination of nanotechnology and hyperthermia offers more successful penetration nanoparticles tumor environment, thus allowing targeted region interest. At same time, unlike radiotherapy, use non-ionizing radiation makes an attractive therapeutic option. This review summarizes existing literature regarding cancer, with a focus on nanoparticle-induced cytotoxicity mechanisms.
Язык: Английский
Процитировано
15
Опубликована: Янв. 1, 2023
This thesis is focused on developing electrochemical (bio-)sensors specifically designed to detect biomolecules and bacteria in human physiological fluids. A more comprehensive understanding of their performance can be obtained by exposing the sensors real Thus, four biosensors were tested saliva, plasma, blood, urine. Specifically, a voltammetric electronic tongue, integrating six different electrode materials, was developed qualitatively assess SARS-CoV-2 saliva samples using principal component analysis. tubular enzyme-based sensor utilizing incorporated cellobiose dehydrogenase an Os(bpy)PVI redox polymer employed for continuous glucose sensing plasma undiluted whole blood under homeostatic conditions. Two concepts label-free detection (Escherichia coli, Enterococcus faecalis, Klebsiella pneumoniae) artificial urine based metabolic activity due bacterial growth. The first enabled reducing Prussian Blue deposited screen-printed electrodes with wireless data transfer. second bacterial-sensitive utilized characterization identify three types changes. For qualitative investigation changes, nuclear magnetic resonance utilized, flow cytometry used quantify correlate growth electrochemistry. Multivariate statistical analysis applied distinguish bacteria-free bacteria-infected Finally, overview recent advances field non-invasive operating secreted fluids, viz., tears, sweat, urine, give
Язык: Английский
Процитировано
13
Advances in chemical and materials engineering book series, Год журнала: 2024, Номер unknown, С. 206 - 230
Опубликована: Фев. 27, 2024
Nanotechnology has emerged as a revolutionary field with diverse applications, including nanocoatings for medicinal purposes. Nanocoatings, their unique properties and capabilities, have opened new avenues drug delivery, medical devices, antimicrobial treatments. Nanocoatings can be engineered to encapsulate therapeutic agents, protecting them from degradation facilitating targeted delivery specific tissues or cells. The use of on surfaces also shown promising results in preventing infections combating antibiotic-resistant pathogens. While offer tremendous potential, concerns about potential toxicity, biocompatibility, long-term effects require rigorous evaluation testing. Furthermore, the study highlights ongoing research future prospects nanocoatings. development multifunctional that combine sensing tissue regeneration holds promise personalized medicine advanced therapeutics.
Язык: Английский
Процитировано
4