Abstract
The
reproductive
characteristics
of
Hanwoo
play
a
significant
role
in
farm
profitability
by
decreasing
the
generation
interval.
This
study
analyzed
1015
primiparous
and
916
multiparous
cows
using
genome‐wide
association
with
both
single‐locus
(GEMMA,
GCTA)
multi‐locus
models
(FarmCPU,
BLINK).
A
marker
for
age
at
first
service
was
identified
across
all
methods.
For
conception,
GEMMA
two
markers,
while
FarmCPU
BLINK
14
respectively.
Regarding
calving,
found
15
In
cows,
except
days
open,
one
gestation
length
markers
calving
interval
were
(FarmCPU
Additionally,
number
services
per
conception
GEMMA.
Key
candidate
genes
included
PLCB1
(maintaining
pregnancy),
MUC1
(fetal
development),
ADCY5
(associated
fetal
birth),
TXNL1
regulates
embryo
implantation
timing.
Gene
ontology
functions
associated
placental
regulation
also
confirmed
(GO:0046875).
Although
greater
genes,
there
no
overlap
results
from
models.
showed
enhanced
detection
power,
but
slight
inflation
test
statistics
(
λ
values)
necessitates
cautious
interpretation
to
avoid
false
positives.
Thus,
combination
is
recommended
improve
efficiency
providing
valuable
insights
into
genetic
aspects
traits.
Journal of Animal Breeding and Genetics,
Год журнала:
2023,
Номер
141(3), С. 235 - 256
Опубликована: Дек. 25, 2023
Abstract
In
the
past
few
decades,
genomic
selection
and
other
refined
strategies
have
been
used
to
increase
growth
rate
lean
meat
production
of
beef
cattle.
Nevertheless,
fast
rates
cattle
breeds
are
often
accompanied
by
a
reduction
in
intramuscular
fat
(IMF)
deposition,
impairing
quality.
Transcription
factors
play
vital
roles
regulating
adipogenesis
lipogenesis
Meanwhile,
understanding
role
transcription
has
gained
significant
attention
IMF
deposition
Therefore,
aim
this
paper
was
provide
comprehensive
summary
valuable
insight
into
complex
This
review
summarizes
contemporary
studies
lipogenesis,
genome‐wide
analysis
factors,
epigenetic
regulation
nutritional
metabolic
signalling
pathways,
functional
genomics
methods,
transcriptomic
profiling
adipose
tissues,
quality
comparative
with
livestock
species.
conclusion,
crucial
promoting
adipocyte
development
fatty
acid
biosynthesis
They
control
tissue
formation
metabolism,
thereby
improving
maintaining
balance.
Understanding
processes
which
these
regulate
lipid
metabolism
will
simplify
marbling
or
composition
Timiryazev Biological Journal,
Год журнала:
2023,
Номер
2, С. 37 - 48
Опубликована: Авг. 10, 2023
This
article
provides
an
overview
of
modern
genetic
technologies
for
improving
production
traits
and
predicting
breeding
value
in
beef
cattle.
In
particular,
marker-assisted
selection
the
most
promising
is
selectionby
desirable
genotypes
genes
myostatin
(MSTN),
calpain
(CAPN),
calpastatin
(CAST),
growth
hormone
(GH),
leptin
(LEP),
thyroglobulin
(TG),
fatty
acid
binding
protein
(FABP),
retinoic
C-receptor
(RORC),
diacyl-glycerol
acyltransferase
(DGATI),
sterol-Co
desaturase
(SCD).
A
much
more
advanced
approach
Single
Step
Genomic
Best
Linear
Unbiased
Predictions
(ssGBLUP)
method,
which
calculates
a
Estimated
Breeding
Value
(GEBV)
using
DNA
chip
genotyping,
phenotype
pedigree
data.
Genome-wide
association
studies
(GWAS),
based
on
use
markers
distributed
throughout
genome
non-equilibrium
linkage
with
at
least
one
quantitative
traits,
are
currently
recognised
as
informative
finding
new
cattle
productivity.
New
associated
live
weight
different
stages
ontogenesis,
average
daily
gain,
residual
feed
intake,
carcass
flesh
content
have
been
identified.
Most
identified
control
cell
division,
lipid
carbohydrate
metabolism.
The
accumulated
data
full-genome
exome
sequencing
led
to
methods
analysis
–
gene
ontology
networks.
networks
provided
first
detailed
understanding
basis
formation
complex
phenotypic
interaction
regulatory
«major»
«peripheral»
controlling
development
particular
trait.
Tropical Animal Science Journal,
Год журнала:
2023,
Номер
46(4), С. 389 - 395
Опубликована: Дек. 1, 2023
Sumba
Ongole
(Bos
indicus)
is
a
native
beef
cattle
that
adapts
well
in
Island
of
Indonesia.
This
study
was
carried
out
to
perform
genome-wide
association
for
body
weight
(BW)
and
carcass
(CW)
(SO)
bulls.
A
total
forty-eight
(n=48)
SO
bulls
were
used
this
study.
The
data
collected
from
the
slaughterhouse
at
Bogor
City,
West
Java,
Indonesia,
analyzed
using
genomic
software
TASSEL
5.0
obtain
best
genetic
marker.
result
showed
threshold
Manhattan
plot
(-Log10P3)
select
SNP
markers
BW
CW
two
(2)
BTA1,
i.e.,
ARS-BFGL-NGS-3162
(CEP63
gene)
ARS-BFGL-NGS-78232
significantly
associated
with
CW,
respectively.
Nonetheless,
diversity
both
low,
PIC
value
less
than
0.30.
In
conclusion,
heterozygous
TG
CEP63
gene
have
higher
homozygous
TT
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9745 - 9745
Опубликована: Сен. 9, 2024
Understanding
the
pig
immune
function
is
crucial
for
disease-resistant
breeding
and
potentially
human
health
research
due
to
shared
system
features.
Immune
cell
ratios,
like
monocyte/lymphocyte
ratio
(MLR)
neutrophil/lymphocyte
(NLR),
offer
a
more
comprehensive
view
of
status
compared
individual
counts.
However,
on
ratios
remains
limited.
This
study
investigated
MLR
NLR
in
Duroc
×
Erhualian
F2
resource
population.
Heritability
analysis
revealed
high
values
(0.649
0.688
NLR,
respectively),
suggesting
strong
genetic
component.
Furthermore,
we
employed
an
ensemble-like
GWAS
(E-GWAS)
strategy
functional
annotation
identify
11
MLR-associated
6
NLR-associated
candidate
genes.
These
genes
were
significantly
enriched
immune-related
biological
processes.
findings
provide
novel
markers
associated
with
porcine
immunity,
thereby
providing
valuable
insights
addressing
biosecurity
animal
welfare
concerns
industry.
Animals,
Год журнала:
2024,
Номер
14(20), С. 2995 - 2995
Опубликована: Окт. 17, 2024
Spotted
sea
bass
(Lateolabrax
maculatus)
is
an
important
marine
economic
fish
in
China,
ranking
third
annual
production
among
fish.
However,
a
declined
growth
rate
caused
by
germplasm
degradation
has
severely
increased
costs
and
reduced
benefits.
There
urgent
need
to
develop
the
fast-growing
varieties
of
L.
maculatus
elucidate
genetic
mechanisms
underlying
traits.
Here,
whole-genome
resequencing
technology
combined
with
extreme
phenotype
genome-wide
association
analysis
(XP-GWAS)
was
used
identify
candidate
markers
genes
associated
traits
maculatus.
Two
groups
maculatus,
consisting
100
slow-growing
individuals
significant
differences
body
weight,
length,
carcass
underwent
resequencing.
A
total
4,528,936
high-quality
single
nucleotide
polymorphisms
(SNPs)
were
for
XP-GWAS.
These
SNPs
evenly
distributed
across
all
chromosomes
without
large
gaps,
average
distance
between
only
175.8
bp.
XP-GWAS
based
on
Bayesian-information
Linkage-disequilibrium
Iteratively
Nested
Keyway
(Blink)
Fixed
random
model
Circulating
Probability
Unification
(FarmCPU)
identified
50
growth-related
markers,
which
17
related
19
23
weight.
The
highest
phenotypic
variance
explained
(PVE)
reached
15.82%.
Furthermore,
observed
weight
different
genotypes.
For
example,
there
highly
genotypes
four
located
chromosome
16:
chr16:13133726,
chr16:13209537,
chr16:14468078,
chr16:18537358.
Additionally,
47
growth-associated
annotated.
are
mainly
metabolism
energy,
glucose,
lipids
development
musculoskeletal
nervous
systems,
may
regulate
Our
study
genes,
will
help
through
marker-assisted
breeding
Abstract
The
reproductive
characteristics
of
Hanwoo
play
a
significant
role
in
farm
profitability
by
decreasing
the
generation
interval.
This
study
analyzed
1015
primiparous
and
916
multiparous
cows
using
genome‐wide
association
with
both
single‐locus
(GEMMA,
GCTA)
multi‐locus
models
(FarmCPU,
BLINK).
A
marker
for
age
at
first
service
was
identified
across
all
methods.
For
conception,
GEMMA
two
markers,
while
FarmCPU
BLINK
14
respectively.
Regarding
calving,
found
15
In
cows,
except
days
open,
one
gestation
length
markers
calving
interval
were
(FarmCPU
Additionally,
number
services
per
conception
GEMMA.
Key
candidate
genes
included
PLCB1
(maintaining
pregnancy),
MUC1
(fetal
development),
ADCY5
(associated
fetal
birth),
TXNL1
regulates
embryo
implantation
timing.
Gene
ontology
functions
associated
placental
regulation
also
confirmed
(GO:0046875).
Although
greater
genes,
there
no
overlap
results
from
models.
showed
enhanced
detection
power,
but
slight
inflation
test
statistics
(
λ
values)
necessitates
cautious
interpretation
to
avoid
false
positives.
Thus,
combination
is
recommended
improve
efficiency
providing
valuable
insights
into
genetic
aspects
traits.
