ImmunoTargets and Therapy, Год журнала: 2024, Номер Volume 13, С. 585 - 593
Опубликована: Ноя. 1, 2024
Endometriosis is a complex gynecological condition in which endometrial fragments are implanted outside the uterus, causing pain and infertility. Although immune mediators play vital role endometriosis, their exact etiology remains elusive. Using Mendelian randomization (MR), this study aimed to assess causal relationship between inflammatory proteins endometriosis.
Язык: Английский
Frontiers in Endocrinology, Год журнала: 2024, Номер 15
Опубликована: Май 31, 2024
Background Previous observational epidemiological studies reported an association between cathepsins and cancer, however, a causal relationship is uncertain. This study evaluated the cancer using Mendelian randomization (MR) analysis. Methods We used publicly available genome-wide (GWAS) data for bidirectional MR Inverse variance weighting (IVW) was as primary method of Results After correction False Discovery Rate (FDR), two were found to be significantly associated with risk: cathepsin H (CTSH) levels increased risk lung (OR = 1.070, 95% CI 1.027–1.114, P 0.001, FDR 0.009), CTSH decreased basal cell carcinoma 0.947, 0.919–0.975, 0.0002, 0.002). In addition, there no statistically significant effect 20 cancers on nine cathepsins. Some unadjusted low P-value phenotypes are worth mentioning, including positive correlation O (CTSO) breast 1.012, 1.001–1.025, 0.041), S (CTSS) pharyngeal 1.017, 1.001–1.034, 0.043), CTSS endometrial 1.055, 1.012–1.101, 0.012); negative Z ovarian (CTSZ) 0.970, 0.949–0.991, 0.006), prostate 0.902–0.944, 0.028), E (CTSE) pancreatic 0.963, 0.938–0.990, 0.006). Conclusion Our analyses showed may help provide new insights further mechanistic clinical cathepsin-mediated cancer.
Язык: Английский
Процитировано
6
Thrombosis Journal, Год журнала: 2024, Номер 22(1)
Опубликована: Март 29, 2024
Abstract Objective To investigate the genetic underpinnings of association between type 2 diabetes (T2D), glycemic indicators such as fasting glucose (FG), insulin (FI), and glycated hemoglobin (GH), venous thromboembolism (VTE), encompassing deep vein thrombosis (DVT) pulmonary embolism (PE), thereby contributing novel insights to scholarly discourse within this domain. Methods Genome-wide study (GWAS) summary data pertaining exposures (T2D, FG, FI, GH) outcomes (VTE, DVT, PE) were acquired from IEU Open GWAS database, participants European descent, including both male female individuals. Two-sample Mendelian randomization (MR) analyses conducted utilizing TwoSampleMR MRPRESSO packages R programming environment. The primary analytical approach employed was random-effects inverse variance weighted (IVW) method. Heterogeneity assessed via Cochran’s Q statistic for MR-IVW Rucker’s MR-Egger. Horizontal pleiotropy evaluated using intercept test MR Egger residual sum outlier (MR-PRESSO) analysis, with latter also detection. Additionally, a “Leave one out” analysis ascertain influence individual single nucleotide polymorphisms (SNPs) on results. Results IVW revealed negative causal T2D) VTE ( P = 0.008, Odds Ratio [OR] 95% confidence interval [CI] 0.896 [0.827–0.972]), well FG 0.002, OR CI 0.655 [0.503–0.853]), GH 0.010, 0.604 [0.412–0.884]), DVT 0.413 [0.235–0.725]). Conversely, did not detect relationship FI > 0.05), nor T2D, or PE 0.05). Both MR-Egger indicated no significant heterogeneity Moreover, tests MR-PRESSO suggested absence horizontal identified outliers, while underscored that influenced by any SNP. Conclusion Our investigation exhibit relationships at level, demonstrates level. These findings furnish genetic-level evidence warranting further examination VTE, PE, making contribution advancement related research domains.
Язык: Английский
Процитировано
1
BMC Medical Genomics, Год журнала: 2024, Номер 17(1)
Опубликована: Июнь 12, 2024
Abstract Background Association between glucose and inflammatory bowel disease (IBD) was found in previous observational studies cohort studies. However, it is not clear whether these associations reflect causality. Thus, this study investigated there such a causal relation elevated IBD, Crohn’s (CD) ulcerative colitis (UC). Methods We performed two-sample Mendelian Randomization (MR) with the independent genetic instruments identified from largest available genome-wide association (GWAS) for IBD (5,673 cases; 213,119 controls) its main subtypes, CD UC. Summarized data which included 200,622 cases glycemic traits including HbA1c type 2 diabetes(T2DM) were obtained different GWAS Primary secondary analyses conducted by preferentially using radial inverse-variance weighted (IVW) approach. A number of other meta-analysis approach sensitivity carried out to assess robustness results. Results did find effect genetically predicted on as whole (OR 0.858; 95% CI 0.649–1.135; P = 0.286). In subtype also suggestively associated 0.22; 0.04-1.00; 0.05) 0.940; 0.628–1.407; 0.762). direction, subtypes related traits. Conclusions This MR providing any evidence relationship well it’s UC CD. Regarding no could be found. Future robust are needed confirm conclusion.
Язык: Английский
Процитировано
0
IntechOpen eBooks, Год журнала: 2024, Номер unknown
Опубликована: Сен. 13, 2024
Chemokines regulate cell migration by binding to specific surface G protein-coupled receptors in development, physiology, and immune responses. Particularly cancer, chemokines are involved tumor growth, angiogenesis, cancer stem-like properties, metastasis, directly indirectly influencing immunity progression. The chemokine signature the microenvironment affects contexture tissues mutual communication between cells through axis, contributing prognosis. present chapter summarizes role of breast which subtypes classified as luminal A, B, HER2-enriched, basal-like, focusing on expression levels overall survivals a chemokine-dependent manner discovering target axis. outcome provides valuable information that improves quality life patients with supporting treatment options via network microenvironment.
Язык: Английский
Процитировано
0
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(10)
Опубликована: Окт. 18, 2024
Chemokines bind to specific chemokine receptors, known as cell surface G protein-coupled constructing axes which lead migration and invasion in developmental stage, pathophysiological process, immune reactions. The the tumor microenvironment are involved growth, angiogenesis, cancer stem-like properties, metastasis, chemoresistance, modifying contexture progression. Clinical features, including state, grade, lymph node subtypes, related axes, play a significant role interaction microenvironment, followed by altered prognosis overall survival. present review summarizes of breast cancer, based on data obtained from line animal models human samples. This provides information that understand important roles each axis probably offering clue adjuvant therapeutic options improve quality life survival for patients with cancer.
Язык: Английский
Процитировано
0
ImmunoTargets and Therapy, Год журнала: 2024, Номер Volume 13, С. 585 - 593
Опубликована: Ноя. 1, 2024
Endometriosis is a complex gynecological condition in which endometrial fragments are implanted outside the uterus, causing pain and infertility. Although immune mediators play vital role endometriosis, their exact etiology remains elusive. Using Mendelian randomization (MR), this study aimed to assess causal relationship between inflammatory proteins endometriosis.
Язык: Английский
Процитировано
0