Skeletal health in DYRK1A syndrome DOI Creative Commons

Elysabeth D. Otte,

Randall J. Roper

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Сен. 6, 2024

syndrome results from a reduction in copy number of the

Язык: Английский

Sex specific emergence of trisomic Dyrk1a-related skeletal phenotypes in the development of a Down syndrome mouse model DOI Creative Commons
Jonathan LaCombe, Kourtney Sloan,

Jared Thomas

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Май 26, 2024

Skeletal insufficiency affects all individuals with Down syndrome (DS) or Trisomy 21 (Ts21) and may alter bone strength throughout development due to a reduced period of formation early attainment peak mass compared typically developing individuals. Appendicular skeletal deficits also appear in males before females DS. In femurs male Ts65Dn DS model mice, cortical were pronounced development, but trabecular

Язык: Английский

Процитировано

2
Sex-specific trisomic Dyrk1a-related skeletal phenotypes during development in a Down syndrome model DOI Creative Commons
Jonathan LaCombe, Kourtney Sloan,

Jared Thomas

и другие.

Disease Models & Mechanisms, Год журнала: 2024, Номер 17(9)

Опубликована: Авг. 13, 2024

ABSTRACT Skeletal insufficiency affects all individuals with Down syndrome (DS) or trisomy 21 and may alter bone strength throughout development due to a reduced period of formation early attainment peak mass compared those in typically developing individuals. Appendicular skeletal deficits also appear males before females DS. In femurs male Ts65Dn DS model mice, cortical were pronounced development, but trabecular Dyrk1a overexpression transitory until postnatal day (P) 30, when there persistent was trending toward overexpression. Correction DS-related by purported DYRK1A inhibitor through genetic means beginning at P21 not effective P30, germline normalization improved structure P36. Trabecular female mice evident P30 subsided P36, typifying periodic developmental normalizations that progressed more prominent deficiencies. Sex-dependent differences delayed impact trisomic are important find temporally specific treatment periods for other phenotypes associated 21.

Язык: Английский

Процитировано

2
Skeletal health in DYRK1A syndrome DOI Creative Commons

Elysabeth D. Otte,

Randall J. Roper

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Сен. 6, 2024

syndrome results from a reduction in copy number of the

Язык: Английский

Процитировано

1