VdCHS2 Overexpression Enhances Anthocyanin Biosynthesis, Modulates the Composition Ratio, and Increases Antioxidant Activity in Vitis davidii Cells DOI Creative Commons
Liyuan He, Gongti Lai, Chun-Yang Lin

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1472 - 1472

Опубликована: Ноя. 29, 2024

Anthocyanins are significant secondary metabolites that essential for plant growth and development, possessing properties such as antioxidant, anti-inflammatory, anti-cancer activities cardiovascular protection. They offer potential applications in food, medicine, cosmetics. However, since anthocyanins mainly obtained through extraction chemical synthesis, they encounter various challenges, including resource depletion, ecological harm, environmental pollution, the risk of toxic residuals. To address these issues, this study proposes a cell factory approach novel alternative solution anthocyanin acquisition. In study, VdCHS2 gene was successfully transformed into spine grape cells, obtaining high-yield line designated OE1. Investigations light spectrum demonstrated white promoted growth, while short-wavelength blue significantly boosted production. Targeted metabolomics analysis revealed total content OE1 reached 11 mg/g, representing 60% increase compared to WT. A 54 differentially accumulated were identified, among which 44 upregulated. Overexpression CHS enhanced expression downstream genes involved biosynthesis, resulting differential CHI, F3Hb, F3′5′H, DFR4, LDOX. This led accumulation monomers, predominantly consisting 3-O-glucosides 3-O-galactosides, thereby causing alterations levels composition. Furthermore, increased activity antioxidant enzymes, improved clearance reactive oxygen species, reduced hydrogen peroxide (H2O2) malondialdehyde (MDA). The subsequent cultivation line, conjunction with suspension culture, established production, increasing yield shortening culture duration. elucidates molecular mechanisms influenced compositional variations. Additionally, it model small-scale factory, providing theoretical practical foundation targeted synthesis components development utilization natural products.

Язык: Английский

Genome-wide identification and comprehensive analysis of the AP2/ERF gene family in Prunus sibirica under low-temperature stress DOI Creative Commons
Hongrui Zhang, Shipeng Wang, Xin Zhao

и другие.

BMC Plant Biology, Год журнала: 2024, Номер 24(1)

Опубликована: Сен. 28, 2024

Язык: Английский

Процитировано

5

A Comprehensive Evolutionary Analysis of the Dihydroflavonol 4-Reductase (DFR) Gene Family in Plants: Insights from 237 Species DOI Open Access
Senlin Luo, Shiping Wang, Ling Yang

и другие.

Genes, Год журнала: 2025, Номер 16(4), С. 396 - 396

Опубликована: Март 29, 2025

Background: Dihydroflavonol 4-reductase (DFR) is a key enzyme in the flavonoid biosynthetic pathway that regulates anthocyanin and proanthocyanidin accumulation plants. Although DFR genes have been studied various species, their origin of gene family, its distribution across plant kingdom, reasons behind emergence different subtypes Methods: This study performed whole-genome analysis 237 including algae, mosses, ferns, gymnosperms, angiosperms, integrating phylogeny, conserved motifs, duplication mechanisms, positive selection, expression pattern analyses. Results: These results indicate family originated from common ancestor extant ferns seed plants, asparagine (Asn)-type aspartic (Asp)-type DFRs associated with gymnosperms. Notably, we report for first time presence Asn-type, Asp-type, arginine (Arg)-type some which breaks previous notion Arg-type are exclusive to ferns. Tandem considered primary driving force expansion formation subtypes. Furthermore, Asn-type were highly expressed during early stages development, suggesting important role development. Conclusions: Overall, this revealed dynamic evolutionary trajectory providing theoretical foundation future research on genes.

Язык: Английский

Процитировано

0

Integrated transcriptomics and metabolomics to explore the mechanisms of Elaeagnus mollis diels seed viability decline DOI Creative Commons

Ren Ruifen,

Jiayi Guo,

Ji Zhe

и другие.

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Апрель 2, 2025

Abstract Elaeagnus mollis Diels, is a rare and endangered woody plant endemic to China, which listed on the IUCN Red List. In natural state, viability of its seeds declines very rapidly, key status, but mechanism E. seed decline still unclear. order explore physiological molecular seeds, this study used fresh as control compare analyze changes vitality, antioxidant system, transcription metabolomics, when were stored for 1 3 months at room temperature. The decreased continuously after month storage. activities superoxide dismutase (SOD), monodehydroascorbate reductase (MDHAR), ascorbate (AsA), glutathione (GSH) significantly, while catalase (CAT) activity increased gradually during viability. Transcriptomic results showed that total 801 differentially expressed genes (DEGs) identified between 1-month-stored 1,524 3-month-stored seeds. Among them, expression CAT , MDHAR GSH GR consistent with indicators. Moreover, WRKY C3H bZIP B3 bHLH NAC AP2 / ERF-ERF factors are important in regulating Metabolomics types differential accumulated metabolites (DAMs) mainly flavonoids, amino acids derivatives, phenolic acids. combined analysis transcriptomics metabolomics further DEGs DAMs associated co-enriched flavonoid biosynthesis tryptophan metabolism pathways. Also 22 genes, including ALDH CHS C4H participating This also illustrated metabolic pathways involved by acting system. These findings provide new insights into .

Язык: Английский

Процитировано

0

Auxin response factor, RhARF8 contributes to rose flower color fading via regulating anthocyanin biosynthesis by directly activating <i>RhCHSa</i>/<i>c</i> promoter activity DOI Creative Commons

Xujun Ma,

Daliang Li, Jing Cai

и другие.

Ornamental Plant Research, Год журнала: 2025, Номер 5(1), С. 0 - 0

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0

Co-overexpression of ZlRc and ZlRd increases flavonoid content, antioxidant activity, and inhibitory effects on against α-glucosidase, α-amylase, pancreatic lipase, and tyrosinase without affecting rice agronomic traits or yield DOI
Qing Ma, Wanhong Li,

Lixia Wang

и другие.

Plant Physiology and Biochemistry, Год журнала: 2025, Номер unknown, С. 110137 - 110137

Опубликована: Июнь 1, 2025

Язык: Английский

Процитировано

0

Genome-Wide Characterization and Expression Analysis of CsPALs in Cucumber (Cucumis sativus L.) Reveal Their Potential Roles in Abiotic Stress and Aphid Stress Tolerance DOI Creative Commons

Jieni Gu,

Hamza Sohail, Lei Qiu

и другие.

Plants, Год журнала: 2024, Номер 13(18), С. 2537 - 2537

Опубликована: Сен. 10, 2024

Phenylalanine ammonia lyase (PAL) is a pivotal enzyme in the phenylalanine metabolic pathway plants and has crucial role plant’s response to environmental stress. Although PAL family been widely studied many plant species, limited known about its particular cucumbers under We investigated physicochemical properties, gene structure, duplication events, conserved motifs, cis-acting elements, protein interaction networks, stress-related transcriptome data, quantitatively validated key genes. The main results indicated that 15 genes were grouped into four clades: I, II, III when arranged phylogenetic tree of angiosperms. analysis promoter sequence revealed presence multiple elements related hormones stress responses cucumber (CsPALs). networks suggested CsPAL1 interacts with eight other members through CsELI5 CsHISNA, directly proteins 4CL family. Further investigation expression patterns CsPAL different tissues various treatments (NaCl, Cu2+, Zn2+, PEG6000, aphids) demonstrated significant differential CsPALs across tissues. In summary, our characterization offers valuable insights provides important clues regarding molecular mechanisms managing abiotic biotic interactions cucumbers.

Язык: Английский

Процитировано

0

VdCHS2 Overexpression Enhances Anthocyanin Biosynthesis, Modulates the Composition Ratio, and Increases Antioxidant Activity in Vitis davidii Cells DOI Creative Commons
Liyuan He, Gongti Lai, Chun-Yang Lin

и другие.

Antioxidants, Год журнала: 2024, Номер 13(12), С. 1472 - 1472

Опубликована: Ноя. 29, 2024

Anthocyanins are significant secondary metabolites that essential for plant growth and development, possessing properties such as antioxidant, anti-inflammatory, anti-cancer activities cardiovascular protection. They offer potential applications in food, medicine, cosmetics. However, since anthocyanins mainly obtained through extraction chemical synthesis, they encounter various challenges, including resource depletion, ecological harm, environmental pollution, the risk of toxic residuals. To address these issues, this study proposes a cell factory approach novel alternative solution anthocyanin acquisition. In study, VdCHS2 gene was successfully transformed into spine grape cells, obtaining high-yield line designated OE1. Investigations light spectrum demonstrated white promoted growth, while short-wavelength blue significantly boosted production. Targeted metabolomics analysis revealed total content OE1 reached 11 mg/g, representing 60% increase compared to WT. A 54 differentially accumulated were identified, among which 44 upregulated. Overexpression CHS enhanced expression downstream genes involved biosynthesis, resulting differential CHI, F3Hb, F3′5′H, DFR4, LDOX. This led accumulation monomers, predominantly consisting 3-O-glucosides 3-O-galactosides, thereby causing alterations levels composition. Furthermore, increased activity antioxidant enzymes, improved clearance reactive oxygen species, reduced hydrogen peroxide (H2O2) malondialdehyde (MDA). The subsequent cultivation line, conjunction with suspension culture, established production, increasing yield shortening culture duration. elucidates molecular mechanisms influenced compositional variations. Additionally, it model small-scale factory, providing theoretical practical foundation targeted synthesis components development utilization natural products.

Язык: Английский

Процитировано

0