Disease as a mediator of somatic mutation-life history coevolution

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Abstract Multicellular organisms are confronted not only with mutation in germline, but also mutations emerging somatic cells. Somatic can lead cancers and possibly contribute to aging phenotypes. Prevailing wisdom suggests limited by evolved defences, either targeting DNA or post-mutational cellular states. Here, I analyse simple models for metazoans humans particular, incorporating the possibility that rate trades-off of organism longevity, defined as age at which natural selection becomes negligible. The assume acts reduce prevent disease, both selecting longer lifespan. We detail equilibrium conditions find coevolutionary oscillations under certain parameter combinations. Notably, disease prevention mutational tolerance this explaining empirical cross-species patterns longevity vs. rate. conclude cancer particular have required characteristics be mediators – lifespan coevolution. results from coevolution incidences other diseases conditions, including aging.

Язык: Английский

The evolution of ageing: classic theories and emerging ideas

Biogerontology, Год журнала: 2024, Номер 26(1)

Опубликована: Окт. 29, 2024

Язык: Английский