Insect Resistance to Insecticides: Causes, Mechanisms, and Exploring Potential Solutions
Archives of Insect Biochemistry and Physiology,
Год журнала:
2025,
Номер
118(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Insecticides
play
a
crucial
role
as
the
primary
means
of
controlling
agricultural
pests,
preventing
significant
damage
to
crops.
However,
misuse
these
insecticides
has
led
development
resistance
in
insect
pests
against
major
classes
chemicals.
The
emergence
poses
serious
threat,
especially
when
alternative
options
for
crop
protection
are
limited
farmers.
Addressing
this
challenge
and
developing
new,
effective,
sustainable
pest
management
approaches
is
not
merely
essential
but
also
critically
important.
In
absence
solutions,
understanding
root
causes
behind
insects
becomes
critical
necessity.
Without
understanding,
formulation
effective
combat
remains
elusive.
With
playing
vital
global
food
security
public
health,
mitigating
paramount.
Given
growing
concern
over
insecticides,
review
addresses
research
gap
by
thoroughly
examining
causes,
mechanisms,
potential
solutions.
examines
factors
driving
resistance,
such
evolutionary
pressure
excessive
pesticide
use,
provides
detailed
analysis
including
detoxifying
enzyme
overproduction
target
site
mutations.
Providing
an
it
discusses
integrated
management,
strategic
insecticide
rotation,
use
new
control
technologies
biological
agents.
Emphasizing
urgency
multifaceted
approach,
concise
roadmap
guiding
future
applications.
Язык: Английский
Metabolic resistance to pyrethroids with possible involvement of non-coding ribonucleic acids in Anopheles funestus, the major malaria vector in western Kenya
BMC Genomics,
Год журнала:
2025,
Номер
26(1)
Опубликована: Янв. 23, 2025
The
resurgence
of
Anopheles
funestus,
a
dominant
vector
human
malaria
in
western
Kenya
was
partly
attributed
to
insecticide
resistance.
However,
evidence
on
the
molecular
basis
pyrethroid
resistance
is
limited.
Here,
we
reported
metabolic
mechanisms
and
demonstrated
that
multiple
non-coding
Ribonucleic
Acids
(ncRNAs)
could
play
potential
role
An.
funestus
Kenya.
mosquitoes
were
sampled
using
aspiration
methods
Bungoma,
Teso,
Siaya,
Port
Victoria
Kombewa
F1
progenies
exposed
deltamethrin
(0.05%),
permethrin
(0.75%),
DDT
(4%)
pirimiphos-methyl
(0.25%)
following
WHO
test
guidelines.
A
synergist
assay
piperonyl
butoxide
(PBO)
conducted
determine
cytochrome
P450s'
RNA-seq
combined
pool
specimens
resistant
unexposed,
results
compared
with
those
FANG
susceptible
reference
strain.
This
approach
aimed
uncover
underlying
observed
phenotypic
Pyrethroid
all
sites
an
average
mortality
rate
(MR)
57.6%.
had
highest
level
(MR
=
53%)
11%.
Teso
lowest
70%)
87%).
Resistance
only
89%)
85%).
full
susceptibility
P-methyl
sites.
PBO
revealed
high
(>
98%)
pyrethroids
except
for
96%).
Whole
transcriptomic
analysis
showed
most
gene
families
associated
comprised
RNAs
(67%),
followed
by
immunity
proteins
(10%),
P450s
(6%),
cuticular
(5%),
olfactory
(4%),
glutathione
S-transferases
(3%),
UDP-glycosyltransferases
(2%),
ATP-binding
cassettes
(2%)
carboxylesterases
(1%).
study
unveils
Kenya,
highlighting
first
time
alongside
detoxification
Targeting
intervention
development
help
management.
Язык: Английский
Increased expression of an isoform of the long non-coding RNA, lnc37707, is associated with malathion resistance in Bactrocera dorsalis
Pesticide Biochemistry and Physiology,
Год журнала:
2025,
Номер
209, С. 106343 - 106343
Опубликована: Фев. 23, 2025
Язык: Английский
New Insights into the Regulatory Non-Coding RNAs Mediating Rice–Brown Planthopper Interactions
Agronomy,
Год журнала:
2025,
Номер
15(3), С. 686 - 686
Опубликована: Март 13, 2025
The
brown
planthopper
(Nilaparvata
lugens
Stål,
BPH)
is
a
destructive
pest
of
rice.
Non-coding
RNAs
(ncRNAs)
regulate
the
defense
mechanisms
in
rice
and
adaptive
strategies
BPHs.
In
rice,
ncRNAs
modulate
key
resistance
pathways
such
as
jasmonic
acid
biosynthesis,
flavonoid
production,
phenylpropanoid
metabolism,
which
increases
BPH
resistance.
BPHs,
processes
reproduction,
wing
polyphenism,
facilitate
adaptation
virulence.
Cross-kingdom
interactions
between
BPHs
reveal
dynamic
molecular
interplay
that
underpins
this
pest–host
relationship.
These
new
insights
into
ncRNA
functions
will
help
improve
innovative
management
equip
varieties
with
enhanced
Язык: Английский
Physiological and Molecular Mechanisms of Lepidopteran Insects: Genomic Insights and Applications of Genome Editing for Future Research
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(22), С. 12360 - 12360
Опубликована: Ноя. 18, 2024
Lepidopteran
insects
are
a
major
threat
to
global
agriculture,
causing
significant
crop
losses
and
economic
damage.
Traditional
pest
control
methods
becoming
less
effective
due
the
rapid
evolution
of
insecticide
resistance.
This
study
explores
current
status
genomic
characteristics
1315
records,
alongside
an
overview
relevant
research,
utilizing
advanced
functional
genomics
techniques,
including
RNA-seq
CRISPR/Cas9
gene-editing
technologies
uncover
molecular
mechanisms
underlying
Our
analysis
revealed
variability
in
genome
size,
assembly
quality,
chromosome
number,
which
may
influence
species'
biology
resistance
mechanisms.
We
identified
key
resistance-associated
genes
pathways,
detoxification
metabolic
help
these
evade
chemical
control.
By
employing
we
directly
manipulated
confirm
their
roles
resistance,
demonstrating
potential
for
targeted
interventions
management.
These
findings
emphasize
value
integrating
data
into
development
sustainable
strategies,
reducing
reliance
on
insecticides
promoting
environmentally
friendly
integrated
management
(IPM)
approaches.
highlights
critical
role
IPM
its
provide
long-term
solutions
growing
challenge
Язык: Английский