Frontiers in Physiology,
Год журнала:
2022,
Номер
13
Опубликована: Март 10, 2022
A
growing
body
of
evidence
highlights
that
several
insults
during
pregnancy
impact
the
vascular
function
and
immune
response
male
female
offspring.
Overactivation
system
negatively
influences
cardiovascular
contributes
to
disease.
In
this
review,
we
propose
modulation
is
a
potential
link
between
prenatal
stress
offspring
dysfunction.
Glucocorticoids
are
key
mediators
modulate
inflammatory
response.
The
mechanisms
whereby
impacts
in
offspring,
including
poor
hypothalamic–pituitary–adrenal
axis
regulation
response,
activation
Th17
cells,
renin–angiotensin–aldosterone
hyperactivation,
reactive
oxygen
species
imbalance,
generation
neoantigens
TLR4
activation,
discussed.
Alterations
by
maternal
have
broad
relevance
for
dysfunction
immune-mediated
diseases,
such
as
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
145, С. 112419 - 112419
Опубликована: Ноя. 12, 2021
Interleukin-6
(IL-6)
is
a
multi-tasking
cytokine
that
represents
high
activity
in
patients
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
and
cancer.
High
concentration
of
this
pleiotropic
accounts
for
hyperinflammation
storm,
related
to
multi-organ
failure
SARS-CoV-2
induced
disease.
IL-6
promotes
lymphopenia
increases
C-reactive
protein
(CRP)
such
cases.
However,
blockade
not
full-proof
complete
response.
Hypoxia,
hypoxemia,
aberrant
angiogenesis
chronic
inflammation
are
inter-related
events
occurring
as
response
the
stimulatory
effect
on
activity.
Taking
both
pro-
anti-inflammatory
activities
will
make
complex
targeting
patient
The
aim
review
was
discuss
about
interactions
within
body
disease
who
representing
levels,
determine
whether
inhibition
therapy
effective
or
not.
We
also
address
targeted
therapies
cancer
have
Metabolites,
Год журнала:
2023,
Номер
13(4), С. 535 - 535
Опубликована: Апрель 9, 2023
Maternal
prenatal
stress
exposure
affects
the
development
of
offspring.
We
searched
for
articles
in
PubMed
database
and
reviewed
evidence
how
alters
composition
microbiome,
production
microbial-derived
metabolites,
regulates
microbiome-induced
behavioral
changes
The
gut–brain
signaling
axis
has
gained
considerable
attention
recent
years
provides
insights
into
microbial
dysfunction
several
metabolic
disorders.
Here,
we
from
human
studies
animal
models
to
discuss
maternal
can
modulate
offspring
microbiome.
will
probiotic
supplementation
a
profound
effect
on
response,
short
chain
fatty
acids
(SCFAs),
psychobiotics
are
emerging
as
novel
therapeutic
targets.
Finally,
highlight
potential
molecular
mechanisms
by
which
effects
transmitted
mitigation
early-life
risk
factor
improve
birth
outcomes.
Health Care For Women International,
Год журнала:
2025,
Номер
unknown, С. 1 - 21
Опубликована: Фев. 28, 2025
In
this
study,
we
explored
the
impact
of
Nursing
Pregnant
Education
and
Counseling
Program,
grounded
in
Neuman
Systems
Model,
on
stress,
coping,
birth
outcomes
for
high-risk
pregnant
women
susceptible
to
pre-term
labor.
The
study
has
a
pretest-posttest
quasi-experimental
design.
Participants
were
split
into
two
groups:
one
undergoing
Program
(n=30),
other
receiving
standard
clinical
care(n=30).
We
found
significant
difference
stress
perception
coping
scores
between
intervention
control
groups,
favoring
group.
Moreover,
observed
notable
rise
full-term
deliveries
experimental
group,
along
with
decreased
rate
complications
babies
compared
Use
program
resulted
reductions
maternal
improved
use
active
strategies,
favorable
impacts
outcomes.
Frontiers in Microbiomes,
Год журнала:
2025,
Номер
4
Опубликована: Март 20, 2025
The
maternal
microbiome
is
increasingly
being
recognized
as
a
key
determinant
in
various
neonatal
health
outcomes,
including
offspring
immunity,
metabolism,
brain
function,
and
behavior.
While
the
oral,
vaginal,
skin,
gut
microbiota
are
significant
contributors
to
offspring’s
postnatal
microbial
seeding,
composition
diversity
of
during
pregnancy
seems
be
critical
shaping
even
prior
birth.
Growing
evidence
suggests
that
balance
among
groups
their
interactions
with
host
crucial
for
health.
Dysbiotic
communities
early
life
may
lead
disease
processes
offspring,
though
specific
by
which
microbes
affect
development
unknown.
Here,
we
summarize
research
examining
shifts
pregnancy,
effects
on
infant
outcomes.
We
also
discuss
current
theories
how
gastrointestinal
(GI)
tract
influences
probiotics
perinatal
period
Physiology & Behavior,
Год журнала:
2025,
Номер
295, С. 114891 - 114891
Опубликована: Март 31, 2025
Autism
spectrum
disorder
(ASD)
is
characterized
by
significant
heterogeneity
in
the
variety
and
severity
of
symptoms.
Prenatal
stress
and/or
exposure
to
antidepressants
may
be
major
contributors
ASD
heterogeneity.
To
date,
effects
prenatal
or
selective
serotonin
reuptake
inhibitor
have
been
primarily
examined
common
laboratory
rat
mouse
strains
as
opposed
rodent
models
autism.
The
present
experiments
determined
BTBR
model
autism
whether
restraint
(30
min
session
every
2
days
during
G4
-
G18)
SSRI,
fluoxetine
(3
mg/kg
G8
affects
repetitive
motor
behaviors,
anxiety
behavioral
flexibility
offspring
at
adulthood.
Male
female
mice
exhibited
elevated
grooming
behavior
compared
that
C57BL/6
J
(B6)
mice.
manipulations
did
not
affect
male
mice,
but
combination
increased
rearing
jumping.
stress,
significantly
reduced
self-grooming,
while
concomitantly
increasing
locomotion
These
also
jumping
In
B6
conditions
behavior.
addition,
exposed
along
with
prenatally
were
impaired
on
reversal
learning.
had
no
effect
either
strain.
pattern
results
suggest
a
SSRI
long-term
autism-like
behaviors
contribute
co-morbidity
observed
Neuroscience & Biobehavioral Reviews,
Год журнала:
2024,
Номер
165, С. 105859 - 105859
Опубликована: Авг. 17, 2024
Anisman,
H.,
Doubad,
D.,
Asokumar,
A.
&
Matheson,
K.
Psychosocial
and
neurobiological
aspects
of
the
worldwide
refugee
crisis:
From
vulnerability
to
resilience.
NEUROSCI
BIOBEHAV
REV,
XXXX.
Immigration
occurs
between
countries
either
obtain
employment,
for
family
reunification
or
escape
violence
other
life-threatening
conditions.
Refugees
asylum
seekers
are
often
obligated
overcome
a
uniquely
challenging
set
circumstances
prior
during
migration.
Settlement
following
immigration
may
pose
yet
another
stressors
related
acculturation
host
country,
as
well
financial
insecurity,
discrimination,
language
barriers,
social
isolation.
Here
we
discuss
multiple
consequences
experiences,
focusing
on
health
disturbances
that
frequently
develop
in
adults
children.
Aside
from
psychosocial
influences,
immigration-related
challenges
cause
hormonal,
inflammatory
immune,
microbiota
changes
favor
psychological
physical
illnesses.
Some
biological
alterations
subject
modification
by
epigenetic
changes,
which
have
implications
intergenerational
trauma
transmission,
might
disruptions
parenting
behaviors
dysfunction.
Despite
hardships
experienced,
many
immigrants
their
families
exhibit
positive
adjustment
after
resettlement.
We
provide
information
diminish
impacts
associated
with
offer
strength-based
approaches
foster
