Frontiers in Physiology,
Год журнала:
2022,
Номер
13
Опубликована: Март 10, 2022
A
growing
body
of
evidence
highlights
that
several
insults
during
pregnancy
impact
the
vascular
function
and
immune
response
male
female
offspring.
Overactivation
system
negatively
influences
cardiovascular
contributes
to
disease.
In
this
review,
we
propose
modulation
is
a
potential
link
between
prenatal
stress
offspring
dysfunction.
Glucocorticoids
are
key
mediators
modulate
inflammatory
response.
The
mechanisms
whereby
impacts
in
offspring,
including
poor
hypothalamic–pituitary–adrenal
axis
regulation
response,
activation
Th17
cells,
renin–angiotensin–aldosterone
hyperactivation,
reactive
oxygen
species
imbalance,
generation
neoantigens
TLR4
activation,
discussed.
Alterations
by
maternal
have
broad
relevance
for
dysfunction
immune-mediated
diseases,
such
as
Clinical and Experimental Obstetrics & Gynecology,
Год журнала:
2024,
Номер
51(5)
Опубликована: Май 11, 2024
Objective:
Preterm
delivery
remains
the
leading
cause
of
neonatal
morbidity
and
mortality
to
a
burden
lasting
well
beyond
inherent
costs
caring
for
premature
neonate.
Physician-scientists,
scientists,
clinicians
have
intensively
studied
associations,
scoured
every
aspect
determine
modifiable
risk
factors,
trialed
prospective
interventions
generate
best
practices.
We
aimed
useful
review
identification
women
at
preterm
birth
along
with
factors
treatments
help
reduce
delivery.
Mechanism:
performed
literature
search
prevention
facilitate
compilation
narrative
review.
Findings
in
Brief:
The
PROLONG
study
found
that
Makena
did
not
significantly
(PTB)
<35
weeks
among
those
history
PTB
<37
weeks;
rate
was
11.5%
placebo
group
11.0%
17
alpha-hydroxyprogesterone
caproate
(17-OHP)
group,
(relative
(RR)
0.95,
95%
confidence
interval
(95%
CI)
0.71–1.26,
p
=
0.72)
led
American
College
Obstetricians
Gynecologists
no
longer
recommend
use
birth.
Nonetheless,
number
tools
screening
behavior
modification
remain
utilize
patient
care:
(1)
alabama
Prevention
project
showed
high
negative
predictive
value
cervical
length
excess
2.0
cm
birth,
particularly
prior
less
than
34
(hazard
ratio
(HR)
2.8,
<
0.0001;
RR
2.1,
0.0001);
(2)
treatment
infections;
e.g.,
antibiotic
urinary
tract
infections
may
be
associated
reduction
(RR
0.34,
CI
0.13–0.88);
(3)
discontinuation
tobacco
illicit
drug
given
association
birth;
(4)
vaginal
dysbiosis
or
pathologic
alterations
flora
poses
as
opportunity
(e.g.,
bacterial
vaginosis
confers
2.9
fold
increased
birth).
Conclusions:
Many
associations
behaviors
conditions
been
identified
care
Evidence-based
therapeutic
intervention
includes
nutritional
deficits,
infections,
short
cervix,
insufficiency.
Future
studies
on
alteration
microbiome
identify
additional
therapy
incidence
Frontiers in Microbiology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 12, 2024
Commensal
microbial-host
interaction
is
crucial
for
host
metabolism,
growth,
development,
and
immunity.
However,
research
on
immunity
in
large
animal
models
has
been
limited.
This
study
was
conducted
to
investigate
the
effects
of
commensal
microbiota
immune
function
two
model
groups:
germ-free
(GF)
specific-pathogen-free
(SPF)
piglets.
The
weight
organ
index
spleen
GF
piglet
were
larger
than
those
SPF
(
Children,
Год журнала:
2024,
Номер
11(7), С. 783 - 783
Опубликована: Июнь 27, 2024
The
moment
of
birth
represents
a
complex
physiological
process
that
is
followed
by
adaptive
changes
in
the
vital
systems
newborn.
Such
reactions
have
their
positive
but
also
negative
effects.
aim
this
research
was
to
determine
difference
laboratory
values
stress
indicators
newborn
children
delivered
cesarean
section
(CS)
with
general
and
spinal
anesthesia.
We
attempted
make
recommendation
about
optimal
type
anesthesia
based
on
our
results.
Frontiers in Physiology,
Год журнала:
2022,
Номер
13
Опубликована: Март 10, 2022
A
growing
body
of
evidence
highlights
that
several
insults
during
pregnancy
impact
the
vascular
function
and
immune
response
male
female
offspring.
Overactivation
system
negatively
influences
cardiovascular
contributes
to
disease.
In
this
review,
we
propose
modulation
is
a
potential
link
between
prenatal
stress
offspring
dysfunction.
Glucocorticoids
are
key
mediators
modulate
inflammatory
response.
The
mechanisms
whereby
impacts
in
offspring,
including
poor
hypothalamic–pituitary–adrenal
axis
regulation
response,
activation
Th17
cells,
renin–angiotensin–aldosterone
hyperactivation,
reactive
oxygen
species
imbalance,
generation
neoantigens
TLR4
activation,
discussed.
Alterations
by
maternal
have
broad
relevance
for
dysfunction
immune-mediated
diseases,
such
as
