International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6750 - 6750
Опубликована: Июнь 19, 2024
The
management
of
advanced
bladder
carcinoma
involves
a
multidisciplinary
approach,
but
the
prognosis
remains
poor
for
many
patients.
immune
system
plays
crucial
role
in
this
disease,
influencing
both
tumor
development
and
response
to
treatment,
exploiting
against
can
be
valuable
strategy
destroy
neoplastic
cells.
This
is
biological
principle
underlying
Bacillus
Calmette-Guérin
(BCG)
use
and,
more
recently,
checkpoint
inhibitors
(ICIs),
like
PD-1
(programmed
death-1)/PD-L1
death-ligand
1)
inhibitors.
In
fact,
one
best
studied
checkpoints
represented
by
PD-1/PD-L1
axis,
which
well-known
escape
adopted
PD-L1
expression
has
been
associated
with
higher
pathologic
stage
shown
prognostic
value
carcinoma.
Interestingly,
high-grade
cancers
tend
express
levels
PD-L1,
suggesting
potential
such
an
axis
mediating
disease
progression.
Immunotherapy
therefore
emerged
as
treatment
option
efficacy
cancer
patients,
high
better
responses.
Our
review
aims
provide
comprehensive
overview
cancer,
focusing
on
its
implications
decisions
prediction
response.
Overall,
our
work
contribute
understanding
predictive
biomarker
highlight
shaping
therapeutic
approaches
cancer.
Cancers,
Год журнала:
2024,
Номер
16(3), С. 612 - 612
Опубликована: Янв. 31, 2024
Lung
cancer
remains
a
leading
cause
of
death
in
the
United
States
and
globally,
despite
progress
treatment
screening
efforts.
While
mortality
rates
have
decreased
recent
years,
long-term
survival
patients
with
lung
continues
to
be
challenge.
Notably,
African
American
(AA)
men
experience
significant
disparities
compared
European
Americans
(EA)
terms
incidence,
treatment,
survival.
Previous
studies
explored
factors
such
as
smoking
patterns
complex
social
determinants,
including
socioeconomic
status,
personal
beliefs,
systemic
racism,
indicating
their
role
these
disparities.
In
addition
factors,
emerging
evidence
points
variations
tumor
biology,
immunity,
comorbid
conditions
contributing
racial
this
disease.
This
review
emphasizes
differences
patterns,
screening,
early
detection
intricate
interplay
social,
biological,
environmental
that
make
more
susceptible
developing
experiencing
poorer
outcomes.
Molecular Therapy,
Год журнала:
2024,
Номер
32(6), С. 1895 - 1916
Опубликована: Март 27, 2024
Malignant
tumors
are
often
associated
with
an
immunosuppressive
tumor
microenvironment
(TME),
rendering
most
of
them
resistant
to
standard-of-care
immune
checkpoint
inhibitors
(CPIs).
Signal
transducer
and
activator
transcription
3
(STAT3),
a
ubiquitously
expressed
factor,
has
well-defined
functions
in
several
leukocyte
populations
within
the
TME.
Since
STAT3
protein
been
challenging
target
using
conventional
pharmaceutical
modalities,
we
investigated
feasibility
applying
systemically
delivered
RNA
interference
(RNAi)
agents
silence
its
mRNA
directly
tumor-associated
cells.
In
preclinical
rodent
models,
chemically
stabilized
acylated
small
interfering
RNAs
(siRNAs)
selectively
silenced
Stat3
multiple
relevant
cell
types,
reduced
levels,
increased
cytotoxic
T
infiltration.
murine
model
CPI-resistant
pancreatic
cancer,
RNAi-mediated
silencing
resulted
growth
inhibition,
which
was
further
enhanced
combination
CPIs.
To
exemplify
utility
RNAi
for
cancer
immunotherapy,
this
technology
used
Cd274,
gene
encoding
programmed
death-ligand
1
(PD-L1).
Interestingly,
Cd274
effective
models
that
PD-L1
antibody
therapy.
These
data
represent
first
demonstration
systemic
delivery
TME
suggest
immuno-oncology
applications.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6750 - 6750
Опубликована: Июнь 19, 2024
The
management
of
advanced
bladder
carcinoma
involves
a
multidisciplinary
approach,
but
the
prognosis
remains
poor
for
many
patients.
immune
system
plays
crucial
role
in
this
disease,
influencing
both
tumor
development
and
response
to
treatment,
exploiting
against
can
be
valuable
strategy
destroy
neoplastic
cells.
This
is
biological
principle
underlying
Bacillus
Calmette-Guérin
(BCG)
use
and,
more
recently,
checkpoint
inhibitors
(ICIs),
like
PD-1
(programmed
death-1)/PD-L1
death-ligand
1)
inhibitors.
In
fact,
one
best
studied
checkpoints
represented
by
PD-1/PD-L1
axis,
which
well-known
escape
adopted
PD-L1
expression
has
been
associated
with
higher
pathologic
stage
shown
prognostic
value
carcinoma.
Interestingly,
high-grade
cancers
tend
express
levels
PD-L1,
suggesting
potential
such
an
axis
mediating
disease
progression.
Immunotherapy
therefore
emerged
as
treatment
option
efficacy
cancer
patients,
high
better
responses.
Our
review
aims
provide
comprehensive
overview
cancer,
focusing
on
its
implications
decisions
prediction
response.
Overall,
our
work
contribute
understanding
predictive
biomarker
highlight
shaping
therapeutic
approaches
cancer.
