Autoimmunity Reviews, Год журнала: 2024, Номер 23(9), С. 103611 - 103611
Опубликована: Авг. 28, 2024
Язык: Английский
Life Sciences, Год журнала: 2022, Номер 314, С. 121321 - 121321
Опубликована: Дек. 24, 2022
Язык: Английский
Процитировано
71
Journal of Autoimmunity, Год журнала: 2023, Номер 141, С. 103001 - 103001
Опубликована: Март 15, 2023
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by progressive polyarthritis that leads to cartilage and bone damage. Pre-clinical RA prolonged state before clinical develop, in which autoantibodies (antibodies against citrullinated proteins, rheumatoid factors) can be present due the breakdown of immunologic self-tolerance. As early treatment initiation onset may achieve sustained remission, optimize outcomes, even prevent progression, pre-clinical stage showing prospect window opportunity for treatment. Growing evidence has shown role gut microbiota inducing systemic inflammation via multiple mechanisms, involve molecular mimicry, impaired intestinal barrier function, microbiota-derived metabolites mediated immune regulation, modulation microbiota's effect on cells, epithelial cells autophagy, interaction between microbiome human leukocyte antigen alleles as well microRNAs. Since alterations have been reported, potential therapies modifying RA, including natural products, antibiotic therapy, fecal transplantation, probiotics, microRNAs vitamin D supplementation, autophagy inducer-based treatment, prebiotics, diet, holds great promise successful prevention altering ongoing inflammation. In this review, we summarized current studies include pathogenesis progression promising therapeutic strategies provide novel ideas management possibly preventing progression.
Язык: Английский
Процитировано
54
Bone Research, Год журнала: 2023, Номер 11(1)
Опубликована: Янв. 24, 2023
Abstract MicroRNAs (miRNAs), a class of endogenous single-stranded short noncoding RNAs, have emerged as vital epigenetic regulators both pathological and physiological processes in animals. They direct fundamental cellular pathways by fine-tuning the expression multiple genes at posttranscriptional level. Growing evidence suggests that miRNAs are implicated onset development rheumatoid arthritis (RA). RA is chronic inflammatory disease mainly affects synovial joints. This common autoimmune disorder characterized complex multifaceted pathogenesis, its morbidity, disability mortality rates remain consistently high. More in-depth insights into underlying mechanisms required to address unmet clinical needs optimize treatment. Herein, we comprehensively review deregulated impaired functions shed light on several aspects with focus excessive inflammation, hyperplasia progressive joint damage. also provides promising targets for innovative therapies RA. In addition, discuss regulatory roles potential extracellular RA, highlighting their prospective applications diagnostic predictive biomarkers.
Язык: Английский
Процитировано
51
Cell Research, Год журнала: 2023, Номер 33(2), С. 97 - 115
Опубликована: Янв. 5, 2023
Abstract Autoimmunity and autoinflammation arise from aberrant immunological inflammatory responses toward self-components, contributing to various autoimmune diseases autoinflammatory diseases. RNA-binding proteins (RBPs) are essential for immune cell development function, mainly via exerting post-transcriptional regulation of RNA metabolism function. Functional dysregulation RBPs abnormities in closely associated with multiple or disorders. Distinct play critical roles autoreactive orchestrating a complex regulatory network consisting DNAs, RNAs within cells. In-depth characterizations RBP–RNA interactomes during autoimmunity will lead better understanding pathogenesis facilitate the effective therapeutic strategies. In this review, we summarize discuss functions interactions controlling inflammation their potential as biomarkers targets.
Язык: Английский
Процитировано
41
Cells, Год журнала: 2022, Номер 11(3), С. 452 - 452
Опубликована: Янв. 28, 2022
Within the past years, more and attention has been devoted to epigenetic dysregulation that provides an additional window for understanding possible mechanisms involved in pathogenesis of autoimmune rheumatic diseases. Rheumatoid arthritis (RA) is a heterogeneous disease where specific immunologic genetic/epigenetic background responsible manifestations course. In this field, microRNAs (miRNA; miR) are being identified as key regulators immune cell development function. The identification disease-associated miRNAs will introduce us post-genomic era, providing real probability manipulating genetic impact Thereby, different may be good candidates biomarkers diagnosis, prognosis, treatment other clinical applications. Here, we outline not only role inflammatory responses RA, but also present diagnostic/prognostic biomarkers. Research into still its infancy; however, investigation these novel could progress use personalized medicine RA treatment. Finally, discussed possibility miRNA-based therapy patients, which holds promise, given major advances patients with arthritis.
Язык: Английский
Процитировано
42
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Фев. 7, 2022
Rheumatoid arthritis (RA) is one of the most common autoimmune diseases that affect synovitis, bone, cartilage, and joint. RA leads to bone cartilage damage extra-articular disorders. However, pathogenesis still unclear, lack effective early diagnosis treatment causes severe disability, ultimately, death. Accumulating evidence revealed regulatory network includes long non-coding RNAs (lncRNAs)/circular (circRNAs), micro (miRNAs), messenger (mRNA) plays important roles in regulating pathological physiological processes RA. lncRNAs/circRNAs act as miRNA sponge competitively bind regulate expression mRNA synovial tissue, FLS, PBMC, participate regulation proliferation, apoptosis, invasion, inflammatory response. Thereby providing new strategies for its treatment. In this review, we comprehensively summarized mechanisms lncRNA/circRNA-miRNA-mRNA potential biomarkers therapeutic targets
Язык: Английский
Процитировано
32
Inflammation Research, Год журнала: 2022, Номер 71(12), С. 1449 - 1462
Опубликована: Окт. 25, 2022
Язык: Английский
Процитировано
29
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(11), С. 5699 - 5699
Опубликована: Май 23, 2024
Ulcerative colitis (UC), an inflammatory bowel disease (IBD), may increase the risk of colorectal cancer (CRC) by activating chronic proinflammatory pathways. The goal this study was to find serum prediction biomarkers in UC CRC development combining low-density miRNA microarray and biocomputational approaches. expression profiles were compared microarray, finding five upregulated miRNAs specific progression (hsa-let-7d-5p, hsa-miR-16-5p, hsa-miR-145-5p, hsa-miR-223-5p, hsa-miR-331-3p). circRNA/miRNA/mRNA competitive endogenous RNA (ceRNA) network analysis showed that candidate connected well-known colitis-associated ACVR2A, SOCS1, IGF2BP1, FAM126A, CCDC85C mRNAs, circ-SHPRH circRNA. SST SCARA5 genes regulated hsa-let-7d-5p, hsa-miR-331-3p linked a poor survival prognosis patient dataset from Cancer Genome Atlas (TCGA). Lastly, our mRNA candidates validated comparing their differentially expressed mRNAs tissue databases. A high level parallel reduction SOCS1 found serum. We propose possibly hsa-let-7d-5p as novel for predicting CRC. More clinical sample is required further validation.
Язык: Английский
Процитировано
7
International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(3), С. 1506 - 1506
Опубликована: Янв. 25, 2024
Rheumatoid arthritis (RA) is an autoimmune disease that causes inflammation, pain, and ultimately, bone erosion of the joints. The this are multifactorial, including genetic factors, such as presence human leukocyte antigen (HLA)-DRB1*04 variant, alterations in microbiota, or immune factors increased cytotoxic T lymphocytes (CTLs), neutrophils, elevated M1 macrophages which, taken together, produce high levels pro-inflammatory cytokines. In review, we focused on function exerted by osteoclasts osteoblasts other means release exosomal microRNAs (miRNAs). Based a thorough revision, classified these molecules into three categories according to their function: osteoclast inhibitors (miR-23a, miR-29b, miR-214), osteoblast (miR-22-3p, miR-26a, miR-27a, miR-29a, miR-125b, miR-146a), enhancers (miR-20a, miR-34a, miR-96, miR-106a, miR-142, miR-199a, miR-324, miR-486b). Finally, analyzed potential therapeutic targets miRNAs, use antagomiRs, blockmiRs, agomiRs competitive endogenous RNAs (ceRNAs), which already being tested murine ex vivo models RA. These strategies might have important role reestablishing regulation differentiation making progress development personalized medicine.
Язык: Английский
Процитировано
6
Pharmacological Research, Год журнала: 2022, Номер 186, С. 106549 - 106549
Опубликована: Ноя. 8, 2022
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disorder which associated with the dysregulation of autoimmune response. In recent years, early diagnosis, aggressive treatment and alternative therapeutic options disease-modifying anti-rheumatic drugs (DMARDs) markedly improve both management long-term prognosis RA. Since discovery non-coding RNA (ncRNA) including microRNA (miRNA), long (lncRNA) others, their altered expressions have been unraveled to be deregulated in various diseases Several lines evidence are emerging that ncRNA may contribute pathogenesis, disease progression For example, SNP rs2850711 within lnc00305 was indicated associate RA development susceptibility, whereas higher level miR-10a represented good response methotrexate (MTX) patients. aspect refractory RA, also plays an important role by affecting or regulating drug sensitivity Of note, lower expression miR-20a rheumatoid synovial fibroblast (RASFs) demonstrated activate Janus Kinase (JAK)- signal transducer activator transcription 3(STAT3)-mediated inflammation, thereby promoting cell proliferation apoptosis-resistant. this review, we illustrated changes ncRNAs underlying mechanisms whole developing period pathogenesis progression, as well highlighted novel targets/strategies bio-markers for therapy.
Язык: Английский
Процитировано
24