International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4101 - 4101
Опубликована: Апрель 7, 2024
Skin
aging
is
a
complex
process
involving
structural
and
functional
changes
characterized
by
decrease
in
collagen
content,
reduced
skin
thickness,
dryness,
the
formation
of
wrinkles.
This
underpinned
multiple
mechanisms
including
free
radical
theory,
inflammation
photoaging
metabolic
theory.
The
immune
system,
an
indispensable
part
body’s
defense
mechanism,
comprises
macrophages,
lymphocytes,
dendritic
cells,
mast
cells.
These
cells
play
pivotal
role
maintaining
homeostasis
responding
to
injury
or
infection.
As
age
advances,
along
with
various
internal
external
environmental
stimuli,
may
undergo
senescence
accelerated
aging,
cell
division
capability,
increased
mortality,
gene
expression
patterns
signaling
pathways,
altered
functions.
collectively
impact
overall
function
system.
review
summarizes
relationship
between
immunity
explores
characteristics
composition
effects
these
on
aging.
Immune
dysfunction
plays
significant
suggesting
that
immunoregulation
become
one
important
strategies
for
prevention
treatment
Abstract
Diabetic
wounds
have
imposed
a
significant
burden
on
both
patients
and
society
with
prolonged
healing
processes
hindered
by
dysfunctional
skin
repair
cells.
Small
extracellular
vesicles
(sEVs),
as
the
important
media
for
intercellular
communications,
show
promising
therapeutic
potential
in
treating
diabetic
restoring
cellular
functions.
However,
low
yields
limited
bio‐function
of
sEVs
greatly
challenge
their
large‐scale
clinical
use.
Here,
we
briefly
overview
biogenesis
uptake
sEVs,
emphasize
current
advances
improving
optimizing
function
engineering
approaches,
summarize
applications
engineered
wound
treatment.
Furthermore,
undissolved
issues
during
transformation
are
also
discussed.
This
critical
review
aims
to
provide
meaningful
guidance
future
management
wounds.
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 986 - 986
Опубликована: Март 19, 2023
Chronic
wounds
are
one
of
the
secondary
health
complications
that
develop
in
individuals
who
have
poorly
managed
diabetes
mellitus.
This
is
often
associated
with
delays
wound
healing
process,
resulting
from
long-term
uncontrolled
blood
glucose
levels.
As
such,
an
appropriate
therapeutic
approach
would
be
maintaining
concentration
within
normal
ranges,
but
this
can
quite
challenging
to
achieve.
Consequently,
diabetic
ulcers
usually
require
special
medical
care
prevent
such
as
sepsis,
amputation,
and
deformities,
which
these
patients.
Although
several
conventional
dressings,
hydrogels,
gauze,
films,
foams,
employed
treatment
chronic
wounds,
nanofibrous
scaffolds
gained
attention
researchers
because
their
flexibility,
ability
load
a
variety
bioactive
compounds
single
entities
or
combinations,
large
surface
area
volume
ratio,
provides
biomimetic
environment
for
cell
proliferation
relative
dressings.
Here,
we
present
current
trends
on
versatility
novel
platforms
incorporation
agents
suitable
enhancement
healing.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июль 1, 2024
Abstract
Bacterial
infections,
especially
those
from
drug‐resistant
strains,
pose
a
significant
threat
to
healing
diabetic
skin
injuries,
with
current
treatments
being
intricated
and
often
unsatisfactory.
Inspired
by
octopuses,
biomimetic
material
using
α‐cyclodextrin
(α‐CD)
polyethylene
glycol
(PEG)
assembled
graphene
oxide
end‐capped
polyrotaxanes
(GO‐PR)
is
developed,
where
α‐CD
mimics
the
flexible
tentacles
of
an
octopus.
Further,
cationically
modified
polyethyleneimine
(PEI)
resemble
octopus
suction
cups,
creating
GO‐PRP,
which
effectively
captures
adheres
bacteria.
Importantly,
emulate
octopus's
ink
defense,
GO‐PRP
used
as
carrier
for
nitric
(NO),
resulting
in
GO‐PRP/NONOate.
Utilizing
photothermal
conversion
GO,
near‐infrared
light
exposure
triggers
rapid
heating
NO
release,
providing
efficient
antibacterial
activity
biofilm
dispersion,
significantly
reducing
inflammation
injuries
type
I
rats.
During
wound
healing,
sustained
release
promotes
vascular
endothelial
growth
factor
production
blood
vessel
regeneration,
enhancing
collagen
formation
shortening
time
infections.
Thus,
octopus‐inspired
GO‐PRP/NONOate
emerges
novel
biomaterial
treating
bacterial
infections
wounds
biomedical
field.
Diabetic
wound
healing
(DWH)
represents
a
major
complication
of
diabetes
where
inflammation
is
key
impediment
to
proper
healing.
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
interferon
genes
(STING)
signaling
pathway
has
emerged
as
central
mediator
inflammatory
responses
cell
stress
and
damage.
However,
the
contribution
cGAS-STING
activation
impaired
in
DWH
remains
understudied.
In
this
review,
we
examine
evidence
that
cGAS-STING-driven
critical
factor
underlying
defective
DWH.
We
summarize
studies
revealing
upregulation
diabetic
wounds
discuss
how
exacerbates
senescence
disrupts
cellular
metabolism
block
Partial
pharmaceutical
inhibition
shown
promise
damping
improving
preclinical
models.
highlight
knowledge
gaps
regarding
DWH,
including
its
relationships
with
endoplasmic
reticulum
metal-ion
signaling.
Elucidating
these
mechanisms
may
unveil
new
therapeutic
targets
within
improve
outcomes
This
review
synthesizes
current
understanding
contributes
pathology
proposes
future
research
directions
exploit
modulation
for
benefit.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(7), С. 4101 - 4101
Опубликована: Апрель 7, 2024
Skin
aging
is
a
complex
process
involving
structural
and
functional
changes
characterized
by
decrease
in
collagen
content,
reduced
skin
thickness,
dryness,
the
formation
of
wrinkles.
This
underpinned
multiple
mechanisms
including
free
radical
theory,
inflammation
photoaging
metabolic
theory.
The
immune
system,
an
indispensable
part
body’s
defense
mechanism,
comprises
macrophages,
lymphocytes,
dendritic
cells,
mast
cells.
These
cells
play
pivotal
role
maintaining
homeostasis
responding
to
injury
or
infection.
As
age
advances,
along
with
various
internal
external
environmental
stimuli,
may
undergo
senescence
accelerated
aging,
cell
division
capability,
increased
mortality,
gene
expression
patterns
signaling
pathways,
altered
functions.
collectively
impact
overall
function
system.
review
summarizes
relationship
between
immunity
explores
characteristics
composition
effects
these
on
aging.
Immune
dysfunction
plays
significant
suggesting
that
immunoregulation
become
one
important
strategies
for
prevention
treatment
