British Journal of Cancer, Год журнала: 2023, Номер 129(9), С. 1397 - 1408
Опубликована: Авг. 5, 2023
Язык: Английский
Briefings in Bioinformatics, Год журнала: 2021, Номер 23(1)
Опубликована: Ноя. 5, 2021
Abstract Long non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression other functional evidence support the idea that lncRNAs have distinct cellular functions tumor microenvironment (TIME). To date, majority lncRNA studies heavily relied on bulk RNA-sequencing data which various types contribute to an averaged signal, limiting discovery functions. Single-cell (scRNA-seq) is a potential solution for tackling this limitation despite lack annotations low abundance yet lncRNAs. Hence, updated further understanding will be necessary characterizing genes TIME. In review, we discuss specifically expressed cells, summarize regulatory at type level highlight how scRNA-seq approach can help study TIME
Язык: Английский
Процитировано
161
Translational Oncology, Год журнала: 2023, Номер 39, С. 101821 - 101821
Опубликована: Ноя. 4, 2023
Cancer heterogeneity and drug resistance remain pivotal obstacles in effective cancer treatment management. One major contributor to these challenges is epigenetic modifications - gene regulation that does not involve changes the DNA sequence itself but significantly impacts expression. As we elucidate phenomena, underscore role of regulating expression, contributing cellular diversity, driving adaptive can instigate therapeutic resistance. This review dissects essential methylation, histone modifications, chromatin remodeling illustrating their significant yet complex contributions biology. While offer potential avenues for intervention due reversible nature, interplay genetic cells presents unique must be addressed harness full potential. By critically analyzing current research landscape, identify knowledge gaps propose future directions, exploring therapies discussing translating concepts into treatments. comprehensive aims stimulate further aid developing innovative, patient-centered therapies. Understanding critical scientific advancement paves way towards improving patient outcomes fight against this formidable disease.
Язык: Английский
Процитировано
54
Molecular Cancer, Год журнала: 2022, Номер 21(1)
Опубликована: Фев. 21, 2022
Abstract Accumulating research suggests that the tumor immune microenvironment (TIME) plays an essential role in regulation of growth and metastasis. The cellular molecular nature TIME influences cancer progression metastasis by altering ratio immune- suppressive versus cytotoxic responses vicinity tumor. Targeting or activating components show a promising therapeutic avenue to combat cancer. success immunotherapy is both astounding unsatisfactory clinic. Advancements RNA-based technology have improved understanding complexity diversity its effects on therapy. TIME-related RNA regulators could be targets for anticancer immunotherapy. In this review, we discuss available immunotherapies targeting TIME. More importantly, summarize potential various therapeutics clinically treatment. RNA-dependent TIME, as monotherapy combined with other evolving therapeutics, might beneficial patients’ treatment near future.
Язык: Английский
Процитировано
61
Non-coding RNA Research, Год журнала: 2024, Номер 9(3), С. 887 - 900
Опубликована: Апрель 4, 2024
In the intricate field of cancer biology, researchers are increasingly intrigued by emerging role exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, and potential therapeutic applications. These lncRNAs, carried within extracellular vesicles, play a vital partin tumorigenesis disease progression facilitating communication networks between tumor cells local microenvironment, making them an ideal candidates for use in liquid biopsy approach. However, lncRNAs remain understudied area, especially biology. Therefore this review aims comprehensively explore dynamic interplay various cellular components, including interactions with tumor-stroma, immune modulation, drug resistance mechanisms. Understanding regulatory functions these processes can potentially unveil novel diagnostic markers targets cancer. Additionally, emergence RNA-based therapeutics presents exciting opportunities targeting offering innovative strategies combat improve treatment outcomes. Thus, provides insights into current understanding highlighting crucial roles, evolving landscape interventions. Furthermore, we have also discussed advantage exosomes as carriers development personalized targeted therapy patients.
Язык: Английский
Процитировано
16
Pathology - Research and Practice, Год журнала: 2024, Номер 262, С. 155570 - 155570
Опубликована: Авг. 29, 2024
Язык: Английский
Процитировано
10
The Kaohsiung Journal of Medical Sciences, Год журнала: 2025, Номер unknown
Опубликована: Март 4, 2025
Abstract Cervical cancer (CC) poses a significant threat to women's health and lives worldwide. Emerging evidence indicates that long noncoding RNA LINC01871 is closely associated with immune regulation in CC patients. However, its specific role underlying mechanisms remain poorly understood. In this study, we examined the expression levels subcellular localization of cell lines. Functional assays, including transwell migration invasion assays as well macrophage phagocytosis were conducted estimate invasiveness, migration, response. Western blotting was performed assess protein markers epithelial–mesenchymal transition (EMT), immunity, MAPK signaling. A luciferase reporter assay used confirm interactions between LINC01871, miR‐873‐3p, MAP3K2. Additionally, xenograft mouse model employed investigate vivo effects on progression. Our results revealed highly expressed predominantly localized cytoplasm knockdown significantly suppressed invasion, EMT, escape vitro reduced tumor growth vivo. Mechanistically, found interact leading upregulation MAP3K2 subsequent activation Furthermore, overexpression rescued inhibitory silencing malignant behaviors cells. conclusion, facilitates metastasis by driving EMT modulating response via miR‐873‐3p/MAP3K2/MAPK signaling pathway.
Язык: Английский
Процитировано
1
Frontiers in Molecular Biosciences, Год журнала: 2022, Номер 9
Опубликована: Фев. 14, 2022
Colon cancer (CC) is one of the most frequent malignancies in world, with a high rate morbidity and death. In CC, necroptosis long noncoding RNA (lncRNAs) are crucial, but mechanism not completely clear. The goal this study was to create new signature that might predict patient survival tumor immunity patients CC. Expression profiles necroptosis-related lncRNAs 473 CC were retrieved from TCGA database. A consensus clustering analysis based on differentially expressed (DE) genes prognostic model least absolute shrinkage selection operator (LASSO) regression conducted. Clinicopathological correlation analysis, expression difference PCA, TMB, GO KEGG enrichment immune prediction clinical therapeutic compounds, qRT-PCR also Fifty-six found be linked prognosis, performed. There substantial variations survival, checkpoint expression, clinicopathological correlations, among different subgroups. Six discovered, split into high-risk low-risk groups risk score generated using these six lncRNAs. time considerably longer than patients, indicating directly associated survival. stage, infiltration depth, lymph node metastasis, distant metastasis. After univariate multivariate Cox stage remained significant. Cancer- metabolism-related pathways enriched by analyses. Immune shown differ significantly between high- immunoassay. Eight compounds screened out, confirmed differential Overall, have an important function, prognosis can predicted They may useful future for customized therapy.
Язык: Английский
Процитировано
36
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Фев. 9, 2022
Tumorigenesis is a complicated process caused by successive genetic and epigenetic alterations. The past decades demonstrated that the immune system affects tumorigenesis, tumor progression, metastasis. Although increasing immunotherapies are revealed, only tiny proportion of them effective. Long non-coding RNAs (lncRNAs) class single-stranded RNA molecules larger than 200 nucleotides essential in molecular network oncology immunology. Increasing researches have focused on connection between lncRNAs cancer immunotherapy. However, in-depth mechanisms still elusive. In this review, we outline latest studies functions microenvironment. Via participating various biological processes such as neutrophil recruitment, macrophage polarization, NK cells cytotoxicity, T functions, regulate invasion, epithelial-mesenchymal transition (EMT), angiogenesis. addition, reviewed current understanding relevant strategies for targeting lncRNAs. LncRNAs-based therapeutics may represent promising approaches serving prognostic biomarkers or potential therapeutic targets cancer, providing ideas future research clinical application diagnosis therapies.
Язык: Английский
Процитировано
35
Molecular and Cellular Biochemistry, Год журнала: 2024, Номер 479(12), С. 3229 - 3254
Опубликована: Фев. 28, 2024
Язык: Английский
Процитировано
9
Biomedicines, Год журнала: 2022, Номер 10(5), С. 1065 - 1065
Опубликована: Май 4, 2022
Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast invade maternal tissues while being tolerated by the immune system. Similarly, can surrounding escape Importantly, both are supported an abetting microenvironment, which influences invasion, angiogenesis, tolerance/evasion, among others. However, in contrast to cells, metabolic, proliferative, migrative, invasive states of under tight regulatory control. In this review, we provide overview similarities dissimilarities processes that drive cell fate, particularly focusing on role microenvironments.
Язык: Английский
Процитировано
25