Exploring Circulating Long Non-Coding RNAs in Mild Cognitive Impairment Patients’ Blood

Опубликована: Окт. 9, 2023

miRNA regulatory axes in blood of MCI patients, which includes lncRNA-SNHG16, lncRNA-H19 and lncRNA-NEAT1. Microarray investigations have demonstrated modifications the expression long non-coding RNAs (lncRNA) patients with compared control samples. This is first study to explore lncRNA profiles Mild Cognitive Impairment blood. Our proposes targets involved molecular pathways connected pathogenesis MCI.

Язык: Английский

Insight into Early Diagnosis of Multiple Sclerosis by Targeting Prognostic Biomarkers

Current Pharmaceutical Design, Год журнала: 2023, Номер 29(32), С. 2534 - 2544

Опубликована: Сен. 1, 2023

Multiple sclerosis (MS) is a central nervous system (CNS) immune-mediated disease that mainly strikes young adults and leaves them disabled. MS an autoimmune illness causes the immune to attack brain spinal cord. The myelin sheaths, which insulate nerve fibers, are harmed by our own cells, this interferes with signal transmission. Numbness, tingling, mood swings, memory problems, exhaustion, agony, vision and/or paralysis just few of symptoms. Despite technological advancements significant research efforts in recent years, diagnosing can still be difficult. Each patient's distinct due heterogeneous complex pathophysiology diverse types courses. There pressing need identify markers will allow for more rapid accurate diagnosis prognosis assessments choose best course treatment each patient. cerebrospinal fluid (CSF) excellent source particular indicators associated pathology. CSF contains molecules represent pathological processes such as inflammation, cellular damage, loss blood-brain barrier integrity. Oligoclonal bands, neurofilaments, MS-specific miRNA, lncRNA, IgG-index, anti-aquaporin 4 antibodies all clinically utilised diagnosis. In slew new possible biomarkers have been presented. review, we look at what know about molecular how they aid differentiation different forms options, monitoring predicting progression, therapy response, consequences during opportunistic infections.

Язык: Английский

Circulating long noncodingRNAs in Mild Cognitive Impairment patients’ blood

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Март 10, 2023

Abstract Mild cognitive impairment (MCI) generally signifies a transitional clinical stage prior to dementia. Cognitive working is dynamic process where both functional decline and improvement are mutual. Patients with amnestic MCI have high risk progress toward Alzheimer’s disease. Both mild sporadic disease multifactorial disorders consequential from multifaceted cross-talk among molecular biological processes. Non-coding RNAs play an important role in the regulation of gene expression, mainly long non-coding (lncRNAs), that regulate other RNA transcripts through binding microRNAs. Cross-talk between RNAs, including coding produces significant regulatory network all transcriptome. The relationship genes non-codingRNAscould improve knowledge genetic factors contributing predisposition pathophysiology MCI. objective this study was identify expression patterns relevant lncRNA-associated miRNA axes blood patients, which includes lncRNA- HAR1A, HAR1B, lncRNA-MEG9, lncRNA-ST7-AS1, lncRNA-TUNAR. Microarray investigations demonstrated modifications (lncRNA) patients compared control samples. This first explore lncRNA profiles Impairment blood. Our proposals targets involved pathways connected pathogenesis

Язык: Английский