Computerized Medical Imaging and Graphics, Год журнала: 2025, Номер unknown, С. 102499 - 102499
Опубликована: Янв. 1, 2025
Язык: Английский
Frontiers in Oncology, Год журнала: 2024, Номер 14
Опубликована: Март 20, 2024
Immune checkpoint molecules are a group of expressed on the surface immune cells that primarily regulate their homeostasis. Chimeric antigen receptor (CAR) T cell therapy is an immunotherapeutic technology realizes tumor-targeted killing by constructing synthetic expressing specific antigens through biotechnology. Currently, CAR-T has achieved good efficacy in non-solid tumors, but its treatment solid tumors not yielded desired results. inhibitors (ICIs) combined with novel combination high expectations to defeat tumors. This review addresses challenges and this
Язык: Английский
Процитировано
21
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(20), С. 15321 - 15321
Опубликована: Окт. 18, 2023
Gastric cancer presents substantial management challenges, and the advent of immunotherapy has ignited renewed hope among patients. Nevertheless, a significant proportion patients do not respond to immunotherapy, adverse events associated with also occur on occasion, underscoring imperative identify suitable candidates for treatment. Several biomarkers, including programmed death ligand-1 expression, tumor mutation burden, mismatch repair status, Epstein–Barr Virus infection, circulating DNA, tumor-infiltrating lymphocytes, have demonstrated potential in predicting effectiveness gastric cancer. However, quest optimal predictive biomarker remains challenging, as each carries its own limitations. Recently, multi-omics technologies emerged promising platforms discovering novel biomarkers that may help selecting likely immunotherapy. The identification reliable holds promise enhancing patient selection improving treatment outcomes. In this review, we aim provide an overview clinically established Additionally, introduce newly reported based studies context thereby contributing ongoing efforts refine stratification strategies.
Язык: Английский
Процитировано
25
Nature Communications, Год журнала: 2024, Номер 15(1)
Опубликована: Июнь 11, 2024
Abstract Cancer diagnosis and management depend upon the extraction of complex information from microscopy images by pathologists, which requires time-consuming expert interpretation prone to human bias. Supervised deep learning approaches have proven powerful, but are inherently limited cost quality annotations used for training. Therefore, we present Histomorphological Phenotype Learning, a self-supervised methodology requiring no labels operating via automatic discovery discriminatory features in image tiles. Tiles grouped into morphologically similar clusters constitute an atlas histomorphological phenotypes (HP-Atlas), revealing trajectories benign malignant tissue inflammatory reactive phenotypes. These distinct can be identified using orthogonal methods, linking histologic, molecular clinical Applied lung cancer, show that they align closely with patient survival, histopathologically recognised tumor types growth patterns, transcriptomic measures immunophenotype. properties maintained multi-cancer study.
Язык: Английский
Процитировано
13
EClinicalMedicine, Год журнала: 2024, Номер 75, С. 102795 - 102795
Опубликована: Авг. 23, 2024
Язык: Английский
Процитировано
11
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(6), С. 5643 - 5643
Опубликована: Март 15, 2023
With the aging of population, malignancies are becoming common complications in patients with rheumatoid arthritis (RA), particularly elderly patients. Such often interfere RA treatment. Among several therapeutic agents, immune checkpoint inhibitors (ICIs) which antagonize immunological brakes on T lymphocytes have emerged as a promising treatment option for variety malignancies. In parallel, evidence has accumulated that ICIs associated numerous immune-related adverse events (irAEs), such hypophysitis, myocarditis, pneumonitis, and colitis. Moreover, not only exacerbate pre-existing autoimmune diseases, but also cause de novo rheumatic disease–like symptoms, arthritis, myositis, vasculitis, currently termed irAEs. Rheumatic irAEs differ from classical diseases multiple aspects, should be individualized based severity. Close collaboration oncologists is critical preventing irreversible organ damage. This review summarizes current regarding mechanisms management focus vasculitis. Based these findings, potential strategies against discussed.
Язык: Английский
Процитировано
21
Cancers, Год журнала: 2023, Номер 15(4), С. 1236 - 1236
Опубликована: Фев. 15, 2023
Salivary gland cancers (SGCs) are diagnosed using histopathological examination, which significantly contributes to their progression, including lymph node/distant metastasis or local recurrence. In the current World Health Organization (WHO) Classification of Head and Neck Tumors: Glands (5th edition), malignant benign epithelial tumors classified into 21 15 tumor types, respectively. All have potential for particular, mucoepidermoid carcinoma (MEC), adenoid cystic (AdCC), salivary duct carcinoma, not otherwise specified (NOS, formerly known as adenocarcinoma, NOS), myoepithelial epithelial–myoepithelial ex pleomorphic adenoma (PA) relatively prevalent. High-grade transformation is an important aspect progression in SGCs. MEC, AdCC, NOS a distinct grading system; however, universal histological system SGCs has yet been recommended. Conversely, PA considered benign; nonetheless, it should be cautiously treated avoid development metastasizing/recurrent PA. The aim this review describe aspects prognostic factors discuss genes molecules used diagnostic tools that might treatment target future.
Язык: Английский
Процитировано
20
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Ноя. 28, 2024
Although immune-checkpoint inhibitors (ICIs) have significantly improved cancer treatment, their effectiveness is limited by primary or acquired resistance in many patients. The gut microbiota, through its production of metabolites and regulation immune cell functions, plays a vital role maintaining balance influencing the response to immunotherapies. This review highlights evidence linking specific microbial characteristics increased therapeutic efficacy variety cancers, such as gastrointestinal melanoma, lung cancer, urinary system reproductive suggesting microbiota’s potential predictive biomarker for ICI responsiveness. It also explores possibility enhancing fecal microbiota transplantation, probiotics, prebiotics, synbiotics, postbiotics, dietary modifications. Moreover, underscores need extensive randomized controlled trials confirm value establish guidelines microbiota-targeted interventions immunotherapy. In summary, article suggests that balanced key maximizing immunotherapy benefits calls further research optimize modulation strategies treatment. advocates deeper comprehension complex interactions between host immunity, therapy, aiming more personalized effective treatment options.
Язык: Английский
Процитировано
7
International Journal of Colorectal Disease, Год журнала: 2024, Номер 40(1)
Опубликована: Дек. 28, 2024
Abstract Purpose Colorectal cancer (CRC) remains one of the leading causes cancer-related mortality worldwide. Metastatic colorectal (mCRC) continues to present significant challenges, particularly in patients with proficient mismatch repair/microsatellite stable (pMMR/MSS) tumors. This narrative review aims provide recent developments immunotherapy for CRC treatment, focusing on its efficacy and challenges. Methods discussed various immunotherapeutic strategies including immune checkpoint inhibitors (ICIs) targeting PD-1 PD-L1, combination therapies involving ICIs other modalities, chimeric antigen receptor T-cell (CAR-T) cell therapy, vaccines. The role tumor microenvironment evasion mechanisms was also explored understand their impact effectiveness these therapies. Results provides a comprehensive update advancements CRC, highlighting potential approaches, inhibitors, therapies, CAR-T vaccination strategies. results MSI-H/dMMR tumors, which have improvements survival rates been observed. Furthermore, this addresses challenges faced treating pMMR/MSS resistant immunotherapy. Conclusion Immunotherapy plays treatment However, many remain, especially CRC. need further research into biomarker development, deeper understanding treatment.
Язык: Английский
Процитировано
7
Scientific Reports, Год журнала: 2025, Номер 15(1)
Опубликована: Янв. 6, 2025
Inflammation can influence the development of CRC as well immunotherapy and plays a key role in CRC. Therefore, this study aimed to investigate potential inflammation-related genes risk prediction. gene models were constructed validated by combining transcriptomic single-cell data from TCGA GEO databases, expression was verified RT-qPCR. We identified two molecular subtypes three genetic subtypes, subgroups according median values, prognostic model including thirteen (TIMP1, GDF15, UCN, KRT4, POU4F1, NXPH1, SIX2, NPC1L1, KLK12, IGFL1, FOXD1, ASPG, CYP4F8), performance each aspect an external database. Patients high-risk group had worse survival with reduced immune cell infiltration greater tumor mutational load. The score correlated strongly checkpoints PD1, PDL1, PDL2, CTLA4, it is possible that patients are more sensitive treatment involving checkpoints. In data, GDF15 most significantly expressed cancer populations. we further their cells tissues using qPCR. summary, developed marker associated inflammatory provide new directions for subsequent studies help clinicians assess prognosis develop personalized strategies.
Язык: Английский
Процитировано
1
Cancer Genetics, Год журнала: 2025, Номер 294-295, С. 21 - 26
Опубликована: Март 6, 2025
Язык: Английский
Процитировано
1