TH Open,
Год журнала:
2023,
Номер
08(01), С. e81 - e92
Опубликована: Дек. 5, 2023
Abstract
Inflammation
and
thrombosis
are
two
distinct
yet
interdependent
physiological
processes.
The
inflammation
results
in
the
activation
of
coagulation
system
that
directs
immune
its
activation,
resulting
initiation
pathophysiology
thrombosis,
a
process
termed
immune-thrombosis.
Still,
shared
underlying
molecular
mechanism
related
to
has
not
been
explored
extensively.
Inspired
answer
this,
we
carried
out
comprehensive
gene
expression
meta-analysis
using
publicly
available
datasets
four
diseases,
including
venous
systemic
lupus
erythematosus,
rheumatoid
arthritis,
inflammatory
bowel
disease.
A
total
609
differentially
expressed
genes
(DEGs)
by
all
were
identified
based
on
combined
effect
size
approach.
pathway
enrichment
analysis
DEGs
showed
various
epigenetic
pathways
such
as
histone-modifying
enzymes,
posttranslational
protein
modification,
chromatin
organization,
chromatin-modifying
HATs
acetylate
proteins.
Network-based
protein–protein
interaction
enzyme
coding
dominating
among
top
hub
genes.
miRNA-interacting
partner
10
was
determined.
predomination
epitranscriptomics
regulation
opens
layout
for
miRNA
same
diseases.
We
30
DEmiRs
these
There
9
common
selected
from
list
partners
significant
microRNAs
dataset
acquisition.
These
found
regulate
involved
modulation
indicate
promising
aspect
needs
be
future
studies
context
immunothrombosis
Gene,
Год журнала:
2024,
Номер
933, С. 149011 - 149011
Опубликована: Окт. 18, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
complex
autoimmune
disease
marked
by
abnormal
B-cell
proliferation
and
increased
autoantibodies.
miRNAs
play
crucial
role
in
regulating
dysfunction
SLE
pathology.
influence
DNA
methylation,
activation,
gene
expression,
contributing
to
pathogenesis.
impact
B
cells
through
key
processes
like
proliferation,
differentiation,
tolerance,
apoptosis.
also
exacerbate
inflammation
immune
responses
modulating
Interleukin
4
(IL-4),
IL-6,
interferon
cytokines.
Autophagy,
degradation
mechanism,
regulated
specific
that
This
article
explores
the
of
multiple
development,
survival,
responses,
influencing
miR-23a,
miR-17
∼
92
family,
miR-125b/miR-221
affect
development
transcription
factors,
signaling
pathways,
cell
cycle
genes.
such
as
miR-181a-5p
miR-23a-5p
are
differentially
across
developmental
stages,
emphasizing
their
regulatory
roles
biology.
synthesizes
miRNA-B
interactions
offer
new
strategies
directions
for
diagnosis
treatment.
Journal of Cellular Immunology,
Год журнала:
2023,
Номер
5(4), С. 116 - 119
Опубликована: Окт. 17, 2023
Systemic
lupus
erythematosus
(SLE)
is
a
common
autoimmune
disease
caused
by
multiple
factors.
The
pathogenesis
of
SLE
remains
unclear.
Helper
T
cell
2
(Th2
cell)
essential
for
humoral
immunity,
which
participates
in
regulating
type
immune
response
producing
typical
cytokines
interleukin
(IL)-4,
IL-5,
and
IL-13.
It
well
known
that
Th2-associated
immunity
plays
vital
role
diseases,
including
SLE.
However,
current
progress
on
the
potential
mechanism
largely
unknown.
work
Wang
et
al.
have
provided
an
in-depth
association
with
clinical
application
perspectives.
We
provide
more
comprehensive
up-to-date
commentary
to
explore
new
therapeutic
targets.
Journal of Inflammation Research,
Год журнала:
2022,
Номер
Volume 15, С. 6021 - 6030
Опубликована: Окт. 1, 2022
The
development
of
microsurgery
has
greatly
advanced
vascularized
composite
allotransplantation
(VCA).
However,
like
organ
transplantation,
VCA
is
also
limited
by
acute
rejection,
and
concerns
regarding
long-term
survival
function
the
transplanted
graft.
Therefore,
it
necessary
to
elucidate
molecular
mechanisms
underlying
rejection
caused
VCA,
in
order
improve
patient
survival.Firstly,
we
used
Brown
Norway
rats
Lewis
construct
animal
model
VCA.
Regularly
record
appearance
changes
all
subjects.
Specimens
were
collected
for
histological
examination,
microRNAs
(miRNAs)
sequencing
RT-qPCR
verification
when
immune
occurred.
Then,
bioinformatics
analysis
was
employed
predict
miRNA
related
molecules
pathway
information.
Finally,
differentially
expressed
miRNAs
tested
verified.MiRNAs
are
small
non
coding
RNA
transcripts
that
regulate
gene
expression
at
post-transcriptional
level.
Studies
have
shown
involved
regulation
several
been
identified
potential
diagnostic
prognostic
biomarkers
rejection.
In
this
study,
found
levels
rno-miR-21-5p,
rno-miR-340-5p,
rno-miR-1-3p
rno-miR-195-5p
significantly
associated
with
following
VCA.This
signature
can
potentially
an
auxiliary
indicator
which
help
clinicians
adjust
immunosuppressive
program
time
during
Egyptian Journal of Medical Human Genetics,
Год журнала:
2023,
Номер
24(1)
Опубликована: Март 7, 2023
Abstract
Background
The
role
of
microRNA
(miRNA)
is
to
regulate
the
translation
genes
involved
in
a
variety
diseases.
Aim
work
This
study
investigated
relation
between
rs636832
and
rs2740348
single-nucleotide
polymorphisms
(SNPs)
AGO1
gene
GEMIN4
miRNA
biogenesis
risk
for
primary
ITP
response
therapy.
Patients
methods
In
this
case–control
study,
100
patients
with
immune
thrombocytopenic
purpura
from
clinical
hematology
department
outpatient
clinic
were
compared
control
subjects.
Patients'
blood
samples
are
taken,
DNA
extraction
PCR
amplification
A/G
G/C
done
on
sera
status
patients.
Results
According
statistical
analysis,
genotype
allele
frequencies
both
variants
did
not
differ
significantly
cases
controls.
GG
was
found
be
more
prevalent
chronic
phase
than
AA
AG
genotypes,
significance
level
p
0.05.
addition,
who
respond
treatment
although
difference
statistically
significant.
Concerning
rs2740348:
CC
common
GC
that
needed
second
line
therapy
like
splenectomy
or
TPO-RA,
but
reach
significance.
Conclusion
SNPs
appear
factors
ITP;
however,
rs636832:GG
older
patients,
tend
have
disease.
Although
distinction
significant,
they
less
responsive
genotypes.
TH Open,
Год журнала:
2023,
Номер
08(01), С. e81 - e92
Опубликована: Дек. 5, 2023
Abstract
Inflammation
and
thrombosis
are
two
distinct
yet
interdependent
physiological
processes.
The
inflammation
results
in
the
activation
of
coagulation
system
that
directs
immune
its
activation,
resulting
initiation
pathophysiology
thrombosis,
a
process
termed
immune-thrombosis.
Still,
shared
underlying
molecular
mechanism
related
to
has
not
been
explored
extensively.
Inspired
answer
this,
we
carried
out
comprehensive
gene
expression
meta-analysis
using
publicly
available
datasets
four
diseases,
including
venous
systemic
lupus
erythematosus,
rheumatoid
arthritis,
inflammatory
bowel
disease.
A
total
609
differentially
expressed
genes
(DEGs)
by
all
were
identified
based
on
combined
effect
size
approach.
pathway
enrichment
analysis
DEGs
showed
various
epigenetic
pathways
such
as
histone-modifying
enzymes,
posttranslational
protein
modification,
chromatin
organization,
chromatin-modifying
HATs
acetylate
proteins.
Network-based
protein–protein
interaction
enzyme
coding
dominating
among
top
hub
genes.
miRNA-interacting
partner
10
was
determined.
predomination
epitranscriptomics
regulation
opens
layout
for
miRNA
same
diseases.
We
30
DEmiRs
these
There
9
common
selected
from
list
partners
significant
microRNAs
dataset
acquisition.
These
found
regulate
involved
modulation
indicate
promising
aspect
needs
be
future
studies
context
immunothrombosis
