Current Drug Targets,
Год журнала:
2023,
Номер
24(16), С. 1239 - 1259
Опубликована: Ноя. 9, 2023
The
diabetic
wound
is
excessively
vulnerable
to
infection
because
the
suggests
delayed
and
incomplete
healing
techniques.
Presently,
wounds
ulcers
related
diabetes
have
additionally
increased
medical
burden.
A
can
impair
mobility,
lead
amputations,
or
even
death.
In
recent
times,
advanced
drug
delivery
systems
emerged
as
promising
approaches
for
enhancing
efficacy
of
treatments
in
patients.
This
review
aims
provide
an
overview
current
advancements
managing
chronic
healing.
begins
by
discussing
pathophysiological
features
wounds,
including
impaired
angiogenesis,
elevated
reactive
oxygen
species,
compromised
immune
response.
These
factors
contribute
susceptibility
infection.
importance
early
intervention
effective
management
strategies
emphasized.
Various
types
are
then
explored,
nanoparticles,
hydrogels,
transferosomes,
liposomes,
niosomes,
dendrimers,
nanosuspension
with
incorporated
bioactive
agents
biological
macromolecules
also
utilized
management.
offer
advantages
such
sustained
release
therapeutic
agents,
improved
targeting
penetration,
enhanced
closure.
Additionally,
highlights
potential
novel
antibiotics,
minerals,
vitamins,
growth
gene
therapy,
stem
cell-based
therapy
outcome
holds
immense
They
innovative
delivering
improving
closure,
addressing
specific
characteristics
wounds.
Wound
healing
is
an
urgent
clinical
challenge,
particularly
in
the
case
of
chronic
wounds.
Traditional
approaches
to
wound
have
limited
therapeutic
efficacy
due
lengthy
times,
risk
immune
rejection,
and
susceptibility
infection.
Recently,
adipose-derived
mesenchymal
stem
cell-derived
exosomes
(ADSC-exos)
emerged
as
a
promising
modality
for
tissue
regeneration
repair.
In
this
study,
development
novel
extracellular
matrix
hydrogel@exosomes
(ECM@exo)
reported,
which
entails
incorporation
ADSC-exos
into
hydrogel
(ECM
hydrogel).
This
solution
forms
at
physiological
temperature
(≈37
°C)
upon
local
injection
site.
ECM@exo
enables
sustained
release
from
ECM
hydrogel,
maintains
high
concentrations
The
displays
good
biocompatibility
biodegradability.
vivo
vitro
results
demonstrate
that
treatment
effectively
reduces
inflammation
promotes
angiogenesis,
collagen
deposition,
cell
proliferation,
migration,
thereby
accelerating
process.
Overall,
innovative
approach
offers
new
avenue
via
biological
with
controlled
exosome
release.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(4), С. 2172 - 2172
Опубликована: Фев. 11, 2024
Fibroblasts
are
stromal
cells
ubiquitously
distributed
in
the
body
of
nearly
every
organ
tissue.
These
were
previously
considered
to
be
“passive
cells”,
solely
responsible
for
ensuring
turnover
extracellular
matrix
(ECM).
However,
their
versatility,
including
ability
switch
phenotypes
response
tissue
injury
and
dynamic
activity
maintenance
specific
homeostasis
integrity
have
been
recently
revealed
by
innovation
technological
tools
such
as
genetically
modified
mouse
models
single
cell
analysis.
highly
plastic
heterogeneous
equipped
with
multifaceted
functions
regulation
angiogenesis,
inflammation
well
innate
stemness
characteristics,
play
a
central
role
delicately
regulated
process
wound
healing.
Fibroblast
dysregulation
underlies
many
chronic
conditions,
cardiovascular
diseases,
cancer,
inflammatory
diabetes
mellitus
(DM),
which
represent
current
major
causes
morbidity
mortality
worldwide.
Diabetic
foot
ulcer
(DFU),
one
most
severe
complications
DM
affects
40
60
million
people.
Chronic
non-healing
DFU
wounds
expose
patients
substantial
sequelae
infections,
gangrene,
amputation,
death.
A
complete
understanding
pathophysiology
targeting
pathways
involved
fibroblasts
required
development
innovative
new
therapeutic
treatments,
critically
needed
these
patients.
Journal of Nanobiotechnology,
Год журнала:
2023,
Номер
21(1)
Опубликована: Июнь 2, 2023
Abstract
Background
Angiogenesis
and
tissue
repair
in
chronic
non-healing
diabetic
wounds
remain
critical
clinical
problems.
Engineered
MSC-derived
exosomes
have
significant
potential
for
the
promotion
of
wound
healing.
Here,
we
discuss
effects
mechanisms
eNOS-rich
umbilical
cord
MSC
(UCMSC-exo/eNOS)
modified
by
genetic
engineering
optogenetic
techniques
on
repair.
Methods
Umbilical
mesenchymal
stem
cells
were
engineered
to
express
two
recombinant
proteins.
Large
amounts
eNOS
loaded
into
UCMSC-exo
using
EXPLOR
system
under
blue
light
irradiation.
The
UCMSC-exo/eNOS
biological
functions
fibroblasts
vascular
endothelial
vitro
evaluated.
Full-thickness
skin
constructed
backs
mice
assess
role
neogenesis
immune
microenvironment,
explore
related
molecular
mechanisms.
Results
was
substantially
enriched
UCMSCs-exo
endogenous
cellular
activities
significantly
improved
after
high-glucose
treatment
reduced
expression
inflammatory
factors
apoptosis
induced
oxidative
stress.
In
vivo,
rate
closure
enhanced
matrix
remodeling
mice.
also
profile
at
site
modulated
associated
thus
promoting
Conclusion
This
study
provides
a
novel
therapeutic
strategy
based
cell-derived
angiogenesis
wounds.
Graphic
Journal of Advanced Research,
Год журнала:
2023,
Номер
54, С. 119 - 131
Опубликована: Янв. 25, 2023
Poor
wound
healing
is
a
significant
complication
of
diabetes,
which
commonly
caused
by
neuropathy,
trauma,
deformities,
plantar
hypertension
and
peripheral
arterial
disease.
Diabetic
foot
ulcers
(DFU)
are
difficult
to
heal,
makes
patients
susceptible
infections
can
ultimately
conduce
limb
amputation
or
even
death
in
severe
cases.
An
increasing
number
studies
have
found
that
epigenetic
alterations
strongly
associated
with
poor
diabetes.This
work
provides
insights
into
the
development
therapeutics
for
improving
chronic
diabetic
healing,
particularly
targeting
regulating
DNA
methylation
demethylation
DFU.
Key
scientific
concepts
review:
play
an
important
part
via
corresponding
signaling
pathways
different
breeds
cells,
including
macrophages,
vascular
endothelial
cells
keratinocytes.
In
this
review,
we
describe
four
main
phases
their
abnormality
patients.
Furthermore,
provided
in-depth
summary
discussion
on
how
regulate
types
cells;
gave
brief
recent
advances
applying
cellular
reprogramming
techniques
healing.
Biomedicines,
Год журнала:
2024,
Номер
12(9), С. 1939 - 1939
Опубликована: Авг. 23, 2024
Chronic
diabetic
foot
ulcers
(DFUs)
are
a
significant
complication
of
diabetes
mellitus,
often
leading
to
amputation,
increased
morbidity,
and
substantial
financial
burden.
Even
with
the
advancements
in
treatment
DFU,
risk
amputation
still
exists,
this
occurs
due
presence
gangrene
osteomyelitis.
Nonhealing
chronic
DFU
is
decreased
angiogenesis,
granulation
tissue
formation,
extracellular
matrix
remodeling
persistent
inflammation.
During
wound
healing,
proliferation
migration
fibroblasts,
smooth
muscle
cells,
keratinocytes
play
critical
role
(ECM)
remodeling,
epithelialization.
The
molecular
factors
regulating
migration,
proliferation,
differentiation
these
cells
scarcely
discussed
literature.
literature
review
identifies
key
influencing
keratinocytes,
vascular
(VSMCs),
which
healing.
This
followed
by
discussion
on
various
novel
but
not
context
healing;
however,
they
may
role.
Using
network
analysis,
we
examined
interactions
between
factors,
findings
suggest
that
identified
promoting
during
healing
or
However,
warrant
further
investigation
establish
their
alone
synergistically.
Journal of Materials Chemistry B,
Год журнала:
2024,
Номер
12(4), С. 1007 - 1021
Опубликована: Янв. 1, 2024
Antibacterial
nanocomposite-integrated
microneedles
were
designed
for
infected
diabetic
wound
therapy.
The
nanocomposite
could
be
destroyed
by
high
glucose
and
exerted
a
powerful
synergistic
antibacterial
effect
against
bacterial
infections.
