Tropical Medicine and Infectious Disease,
Год журнала:
2024,
Номер
9(1), С. 13 - 13
Опубликована: Янв. 4, 2024
Interleukins
(ILs)
are
signaling
molecules
that
crucial
in
regulating
immune
responses
during
infectious
diseases.
Pro-inflammatory
ILs
contribute
to
the
activation
and
recruitment
of
cells,
whereas
anti-inflammatory
help
suppress
excessive
inflammation
promote
tissue
repair.
Here,
we
provide
a
comprehensive
overview
role
pro-inflammatory
diseases,
with
focus
on
mechanisms
underlying
their
effects,
diagnostic
therapeutic
potential,
emerging
trends
IL-based
therapies.
Cells,
Год журнала:
2023,
Номер
12(5), С. 688 - 688
Опубликована: Фев. 22, 2023
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
causes
disease
2019
(COVID-19).
About
45%
of
COVID-19
patients
experience
several
symptoms
a
few
months
after
the
initial
infection
and
develop
post-acute
sequelae
SARS-CoV-2
(PASC),
referred
to
as
“Long-COVID,”
characterized
by
persistent
physical
mental
fatigue.
However,
exact
pathogenetic
mechanisms
affecting
brain
are
still
not
well-understood.
There
is
increasing
evidence
neurovascular
inflammation
in
brain.
precise
role
neuroinflammatory
response
that
contributes
severity
long
COVID
pathogenesis
clearly
understood.
Here,
we
review
reports
spike
protein
can
cause
blood–brain
barrier
(BBB)
dysfunction
damage
neurons
either
directly,
or
via
activation
mast
cells
microglia
release
various
molecules.
Moreover,
provide
recent
novel
flavanol
eriodictyol
particularly
suited
for
development
an
effective
treatment
alone
together
with
oleuropein
sulforaphane
(ViralProtek®),
all
which
have
potent
anti-viral
anti-inflammatory
actions.
Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
67(2), С. 1544 - 1562
Опубликована: Янв. 4, 2024
NLRP3
is
a
molecular
sensor
recognizing
wide
range
of
danger
signals.
Its
activation
leads
to
the
assembly
an
inflammasome
that
allows
for
caspase-1
and
subsequent
maturation
IL-1β
IL-18,
as
well
cleavage
Gasdermin-d
pyroptotic
cell
death.
The
has
been
implicated
in
plethora
diseases
including
gout,
type
2
diabetes,
atherosclerosis,
Alzheimer's
disease,
cancer.
In
this
publication,
we
describe
discovery
novel,
tricyclic,
NLRP3-binding
scaffold
by
high-throughput
screening.
hit
(1)
could
be
optimized
into
advanced
compound
NP3–562
demonstrating
excellent
potency
human
whole
blood
full
inhibition
release
mouse
acute
peritonitis
model
at
30
mg/kg
po
dose.
An
X-ray
structure
bound
NACHT
domain
revealed
unique
binding
mode
compared
known
sulfonylurea-based
inhibitors.
addition,
shows
also
good
overall
development
profile.
Nature Communications,
Год журнала:
2024,
Номер
15(1)
Опубликована: Май 10, 2024
Abstract
As
a
strategy
to
improve
the
therapeutic
success
of
chimeric
antigen
receptor
T
cells
(CART)
directed
against
solid
tumors,
we
here
test
combinatorial
use
CART
and
IMSA101,
newly
developed
stimulator
interferon
genes
(STING)
agonist.
In
two
syngeneic
tumor
models,
improved
overall
survival
is
observed
when
mice
are
treated
with
intratumorally
administered
IMSA101
in
addition
intravenous
infusion.
Transcriptomic
analyses
isolated
from
tumors
show
elevated
cell
activation,
as
well
upregulated
cytokine
pathway
signatures,
particular
IL-18,
combination
treatment
group.
Also,
higher
levels
IL-18
serum
detected
treatment.
Consistent
this,
negative
impair
anti-tumor
responses
receiving
summary,
find
that
enhances
function
which
facilitated
through
STING
agonist-induced
secretion.
Osteoarthritis and Cartilage Open,
Год журнала:
2024,
Номер
6(1), С. 100434 - 100434
Опубликована: Янв. 18, 2024
ObjectivesModic
type
1
changes
(MC1)
are
vertebral
endplate
bone
marrow
(BM)
lesions
observed
on
magnetic
resonance
images
in
sub-populations
of
chronic
low
back
pain
(CLBP)
patients.
The
etiopathogenesis
remains
unknown
and
treatments
that
modify
the
underlying
pathomechanisms
do
not
exist.
We
hypothesized
two
biological
MC1
subtypes
exist:
a
bacterial
non-bacterial.
This
would
have
important
implications
for
developing
targeting
pathomechanisms.MethodsIntervertebral
disc
(IVD)
samples
adjacent
to
(n
=
34)
control
11)
vertebrae
were
collected
from
patients
undergoing
spinal
fusion.
Cutibacterium
acnes
(C.acnes)
genome
copy
numbers
(GCNs)
quantified
IVD
tissues
with
16S
qPCR,
transcriptomic
signatures
cytokine
profiles
determined
BM
by
RNA
sequencing
immunoassay.
Finally,
we
assessed
if
C.acnes
GCNs
associated
blood
plasma
cytokines.ResultsIVD
levels
had
<870
C.acnes
GCNs/gram
IVD.
MC1-adjacent
IVDs
either
"low"
(<870)
or
"high"
(>870)
GCNs.
upregulated
innate
immune
cell
(neutrophil,
macrophage/monocyte)
pro-inflammatory
cytokines
related
neutrophil
macrophage/monocyte
function
BM,
consistent
host
defense
against
bacterium.
increased
adaptive
(T-and
B-cell)
elevated
IL-13
levels.ConclusionOur
study
provides
first
evidence
existence
(C.acnes
"high")
non-bacterial
"low")
CLBP.
supports
need
different
treatment
strategies.
Cells,
Год журнала:
2024,
Номер
13(5), С. 425 - 425
Опубликована: Фев. 28, 2024
Atopic
dermatitis
(AD)
is
an
inflammatory
skin
condition
that
frequently
develops
before
the
onset
of
allergic
rhinitis
or
asthma.
More
than
10%
children
are
affected
by
this
serious
condition,
which
painful
for
sufferers.
Recent
research
has
connected
environment,
genetics,
barrier,
drugs,
psychological
factors,
and
immune
system
to
severity
AD.
The
causes
consequences
AD
its
cellular
molecular
origins
reviewed
in
paper.
exploration
interleukins
their
influence
on
immunological
pathway
been
facilitated
using
relevant
biomarkers
clinical
trials.
This
approach
enables
identification
novel
therapeutic
modalities,
fostering
potential
targeted
translational
within
realm
personalized
medicine.
review
focuses
AD’s
pathophysiology
ever-changing
landscape.
Beyond
plethora
biologic
medications
various
stages
approval
development,
a
range
non-biologic
therapies,
specifically
small
molecules,
have
emerged.
These
include
Janus
kinase
(JAK)
inhibitors
like
Baricitinib,
Upadacitinib,
Abrocitinib,
thus
expanding
spectrum
options.
also
addresses
latest
efficacy
data
elucidates
scientific
rationale
behind
each
treatment
atopic
dermatitis.
Acta Obstetricia Et Gynecologica Scandinavica,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Abstract
Introduction
Graft
optimization
is
a
necessity
in
order
to
develop
uterus
transplantation
from
brain‐dead
donors,
as
complement
living
these
grafts
are
rare
and
the
last
organs
retrieved
multiple
organ
donation.
The
aim
of
this
study
was
assess
feasibility
interest
hypothermic
machine
perfusion
(HMP)
using
porcine
model;
secondary
outcomes
were
evaluation
graft's
tolerance
prolonged
cold
ischaemia
time
find
new
biomarkers
viability.
Material
Methods
Fifteen
allotransplantations
performed
model,
after
18
h
ischaemia,
divided
three
groups:
Static
storage
HTK
solution,
HMP
(with
VitaSmart
(™)
Bridge
Life
Ltd.)
with
UW‐MP
static
UW
solution.
main
outcome
macroscopic:
uterine
arteries
pulsatility,
recoloration,
bleeding
at
cut.
Secondary
histological
analyses
(Zitkute
inflammation
scores),
caspase3
immunohistochemistry
plasmatic
dosage
biomarkers.
Results
14/15
according
protocol
met
criteria
macroscopic
vitality.
Grafts
treated
(MP
did
not
show
significantly
more
tissue)
damage
than
recipient's
uterus,
contrary
storage,
independently
solution
used.
This
difference
disappeared
one
3
transplantation.
Plasma
dosages
before
allow
identify
biomarker
Conclusions
feasible
without
inflicting
on
during
time.
exposed
seemed
better
endure
reperfusion
phenomena,
but
advantage
over
