Regulatory Mechanisms in Biosystems,
Год журнала:
2023,
Номер
14(2), С. 213 - 219
Опубликована: Апрель 15, 2023
The
human
organism
is
home
to
trillions
of
bacteria,
viruses
and
fungi.
In
order
survive,
they
have
adapt
the
living
environment
a
host.
has
adapted
mutual
functioning
by
benefiting
from
microbiota
in
certain
way
or
removing
its
negative
effects.
gut
microorganisms
influence
all
systems,
including
synthesis
heat-shock
proteins.
Their
species
composition
functional
condition
undergo
changes
depending
on
physical
activity
host
organism.
While
moderate
loading
no
doubt
positive
for
diversity
intestinal
barrier,
mechanism
exercises
biodiversity,
coadaptation
yet
be
identified.
Lactobacillus
acidophilus
bacteria
were
found
dominate
long-distance-track
athletes
who
train
endurance,
while
Bacteroidescoccae
dominated
sprinter
runners.
Marathon
runners
many
representatives
conventionally
pathogenic
Veillonella
genus.
They
convert
lactate
into
propionate
acetate
–
substrates
ATF
formation.
Bacteria
generate
an
additional
energy
increase
endurance
athlete.
At
same
time,
cause
inflammatory
process
host’s
gut.
A
temperature-increase
effect
what
adaptation
mechanisms
exercise
bacterial
common.
Rise
temperature
threshold
value
initiates
increased
proteins,
which
regulate
function
barrier
controlling
high-density
are
released
damaged
stressed
cells
act
as
local
“danger
signals”.
Detecting
molecular
interaction
between
subject
can
valuable
identifying
safe
volumes
thresholds
training
load
maintaining
health.
Biomedical Journal of Scientific & Technical Research,
Год журнала:
2024,
Номер
55(3)
Опубликована: Март 5, 2024
Deficiency
of
alkaline
phosphatase
is
characterized
by
bone
hypomineralization.
Alkaline
considered
an
indicator
mineralization.
has
also
been
a
marker
differentiation
osteoblasts.
In
1990,
Dr.
Hui
began
to
study
the
possible
bioactivity
phosphatase.
The
initial
hypothesis
proposed
that
expression
on
cell
surface
not
only
maturation
and
but
promotes
these
processes.
Biomedical Journal of Scientific & Technical Research,
Год журнала:
2024,
Номер
55(3)
Опубликована: Март 4, 2024
Deficiency
of
alkaline
phosphatase
is
characterized
by
bone
hypomineralization.Alkaline
considered
an
indicator
mineralization.Alkaline
has
also
been
a
marker
differentiation
osteoblasts.In
1990,
Dr.
Hui
began
to
study
the
possible
bioactivity
phosphatase.The
initial
hypothesis
proposed
that
expression
on
cell
surface
not
only
maturation
and
but
promotes
these
processes.This
was
substantiated
Hui's
gene
transfer
method,
which
demonstrated
surface-expressed
could
cease
proliferation
augment
volume.Further
investigation
into
recombinant
different
types
revealed
its
role
in
promoting
pathological
calcification.In
1997,
Poelstra
et
al.
found
can
dephosphorylate
inactivate
endotoxin,
suggesting
be
used
treat
acute
kidney
injury,
resulting
from
endotoxin-related
sepsis.AM-Pharma
promoted
injectable
human
complete
three
clinical
studies.Recent
studies
conducted
Gao
indicated
regardless
presence
inhibits
migration
functions
neutrophils.Therefore,
expected
inflammatory
diseases
unrelated
endotoxin.The
showed
dephosphorylates
extracellular
ATP,
ADP,
AMP
adenosine
binds
receptors
cells,
therefore
generating
anti-inflammation
action.The
ATP
hydrolyzed
AMP,
ectonucleotidases
CD39
CD73.In
summary,
CD73
together
play
important
roles
treatment
diseases.
Biomedicines,
Год журнала:
2024,
Номер
12(7), С. 1548 - 1548
Опубликована: Июль 12, 2024
Over
the
past
three
decades,
significant
efforts
have
been
focused
on
unraveling
congenital
intestinal
disorders
that
disrupt
absorption
of
dietary
lipids
and
fat-soluble
vitamins.
The
primary
goal
has
to
gain
deeper
insights
into
intra-enterocyte
sites,
molecular
steps,
crucial
proteins/regulatory
pathways
involved,
while
simultaneously
identifying
novel
therapeutic
targets
diagnostic
tools.
This
research
not
only
delves
specific
rare
malabsorptive
conditions,
such
as
chylomicron
retention
disease
(CRD),
but
also
contributes
our
understanding
normal
physiology
through
utilization
cutting-edge
cellular
animal
models
alongside
advanced
methodologies.
review
elucidates
how
modern
techniques
facilitated
decoding
CRD
gene
defects,
identification
dysfunctional
processes,
regulatory
mechanisms,
essential
role
coat
protein
complex
II-coated
vesicles
cargo
receptors
in
trafficking
endoplasmic
reticulum
(ER)
exit
sites.
Moreover,
experimental
approaches
shed
light
multifaceted
functions
SAR1B
GTPase,
wherein
loss-of-function
mutations
predispose
individuals
exacerbate
oxidative
stress,
inflammation,
ER
potentially
contributing
clinical
complications
associated
with
CRD.
In
addition
dissecting
pathology,
genetically
modified
emerged
invaluable
assets
exploring
various
ancillary
aspects,
including
responses
environmental
challenges
alterations,
gender-specific
disparities
onset
progression,
embryonic
lethality
or
developmental
abnormalities.
summary,
this
comprehensive
provides
an
in-depth
contemporary
analysis
CRD,
offering
a
meticulous
examination
current
landscape
by
synthesizing
latest
findings
advancements
field.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 4, 2024
ABSTRACT
In
the
context
of
type
2
diabetes
mellitus
(T2DM),
concept
organ-specific
insulin
resistance
(IR)
as
a
localized
manifestation
has
garnered
increasing
attention.
A
scoping
review
was
conducted
to
investigate
clinical
relevance
IR
confined
individual
organs
without
systemic
metabolic
implications.
Utilizing
methodological
framework
adapted
from
Arksey
and
O’Malley,
comprehensive
search
PubMed
performed,
focusing
on
period
between
January
1990
October
2024.
The
strategy
combined
Medical
Subject
Headings
terms
keywords
related
specific
organs.
Notably,
while
“insulin
resistance”
yielded
substantial
number
results,
subset
“organ-specific
returned
more
limited
dataset,
highlighting
gap
in
current
literature.
systematic
selection
process
encompassed
identification,
screening,
eligibility,
inclusion
stages
ensure
robust
criteria.
This
underscores
importance
exploring
diabetic
milieu
sets
stage
for
further
research
elucidate
its
role
pathogenesis
T2DM.
Conclusion:
findings
suggest
that
investigating
T2DM
is
promising
avenue
future
deepen
our
understanding
disease
pathophysiology.
Thus,
this
answers
following
question
“In
Situ
Resistance
Insulin
-
Localized
Type
Diabetes
Mellitus
or
6
Mellitus?”,
emphasizing
need
targeted
investigations
into
manifestations
their
implications
DM
management
strategies.
Biomedical Reports,
Год журнала:
2024,
Номер
22(2)
Опубликована: Ноя. 28, 2024
Obstructive
sleep
apnea
(OSA)
is
the
most
common
type
of
apnea,
which
leads
to
episodes
intermittent
hypoxia
due
obstruction
upper
airway.
A
key
feature
OSA
upregulation
and
stabilization
hypoxia‑inducible
factor
1
(HIF‑1),
a
crucial
metabolic
regulator
that
facilitates
rapid
adaptation
changes
in
oxygen
availability.
Adenosine
A2A
receptor
(A2AR),
major
adenosine
receptor,
regulates
HIF‑1
under
hypoxic
conditions,
exerting
anti‑inflammatory
properties
affecting
lipid
metabolism.
The
present
study
explored
roles
A2AR
regulation,
specifically
focusing
on
its
effects
via
PI3K/Akt/HIF‑1
pathway.
findings
enhance
our
understanding
pharmacological
potential
management
suggest
future
research
directions
exploring
clinical
applications.
Molecules,
Год журнала:
2024,
Номер
29(23), С. 5701 - 5701
Опубликована: Дек. 3, 2024
The
natural
5-azaindoles,
marine
sponge
guitarrin
C
and
D,
were
observed
to
exert
inhibitory
activity
against
a
highly
active
alkaline
phosphatase
(ALP)
CmAP
of
the
PhoA
family
from
bacterium
Regulatory Mechanisms in Biosystems,
Год журнала:
2023,
Номер
14(2), С. 213 - 219
Опубликована: Апрель 15, 2023
The
human
organism
is
home
to
trillions
of
bacteria,
viruses
and
fungi.
In
order
survive,
they
have
adapt
the
living
environment
a
host.
has
adapted
mutual
functioning
by
benefiting
from
microbiota
in
certain
way
or
removing
its
negative
effects.
gut
microorganisms
influence
all
systems,
including
synthesis
heat-shock
proteins.
Their
species
composition
functional
condition
undergo
changes
depending
on
physical
activity
host
organism.
While
moderate
loading
no
doubt
positive
for
diversity
intestinal
barrier,
mechanism
exercises
biodiversity,
coadaptation
yet
be
identified.
Lactobacillus
acidophilus
bacteria
were
found
dominate
long-distance-track
athletes
who
train
endurance,
while
Bacteroidescoccae
dominated
sprinter
runners.
Marathon
runners
many
representatives
conventionally
pathogenic
Veillonella
genus.
They
convert
lactate
into
propionate
acetate
–
substrates
ATF
formation.
Bacteria
generate
an
additional
energy
increase
endurance
athlete.
At
same
time,
cause
inflammatory
process
host’s
gut.
A
temperature-increase
effect
what
adaptation
mechanisms
exercise
bacterial
common.
Rise
temperature
threshold
value
initiates
increased
proteins,
which
regulate
function
barrier
controlling
high-density
are
released
damaged
stressed
cells
act
as
local
“danger
signals”.
Detecting
molecular
interaction
between
subject
can
valuable
identifying
safe
volumes
thresholds
training
load
maintaining
health.
