Advances in clinical chemistry, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Язык: Английский
The ISME Journal, Год журнала: 2023, Номер 17(10), С. 1535 - 1551
Опубликована: Авг. 8, 2023
Abstract The symbiotic bacteria that live in the human gut and metabolites they produce have long influenced local systemic physiological pathological processes of host. microbiota are increasingly being recognized for its impact on a range diseases, including cancer, it may play key role occurrence, progression, treatment, prognosis many types cancer. Understanding functional cancer is crucial development era personalized medicine. Here, we review recent advances research summarize important associations clear experimental evidence variety cancers, focus application possible challenges associated with antitumor therapy. In conclusion, our demonstrated multifaceted mechanisms affecting provides directions ideas future clinical research.
Язык: Английский
Процитировано
43
Journal of Clinical Medicine, Год журнала: 2024, Номер 13(21), С. 6578 - 6578
Опубликована: Ноя. 1, 2024
Colorectal cancer (CRC) constitutes a significant global health challenge, with recent studies underscoring the pivotal role of gut microbiome in its pathogenesis and progression. Fecal microbiota transplantation (FMT) has emerged as compelling therapeutic approach, offering potential to modulate microbial composition optimize treatment outcomes. Research suggests that specific bacterial strains are closely linked CRC, influencing both clinical management interventions. Moreover, microbiome's impact on immunotherapy responsiveness heralds new avenues for personalized medicine. Despite promise FMT, safety concerns, particularly immunocompromised individuals, remain critical issue. Clinical outcomes vary widely, influenced by genetic predispositions methodologies employed. Additionally, rigorous donor selection screening protocols paramount minimize risks maximize efficacy. The current body literature advocates establishment standardized further trials substantiate FMT's CRC management. As our understanding deepens, FMT is poised become cornerstone treatment, imperative continued research validation.
Язык: Английский
Процитировано
26
Cancers, Год журнала: 2024, Номер 16(3), С. 676 - 676
Опубликована: Фев. 5, 2024
Traditionally considered a disease common in the older population, colorectal cancer is increasing incidence among younger demographics. Evidence suggests that populational- and generational-level shifts composition of human gut microbiome may be tied to recent trends gastrointestinal carcinogenesis. This review provides an overview current research putative mechanisms behind rising with insight into future interventions prevent or reverse rate early-onset carcinoma.
Язык: Английский
Процитировано
15
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Фев. 13, 2024
T cell senescence is an indication of dysfunction. The ability senescent cells to respond cognate antigens reduced and they are in the late stage differentiation proliferation; therefore, cannot recognize eliminate tumor a timely effective manner, leading formation suppressive microenvironment. Establishing methods reverse particularly important for immunotherapy. Aging exacerbates profound changes immune system, increased susceptibility chronic, infectious, autoimmune diseases. Patients with malignant lung tumors have impaired function high risk recurrence, metastasis, mortality. Immunotherapy based on PD-1, PD-L1, CTLA-4, other checkpoints promising treating malignancies. However, can lead low efficacy or unsuccessful treatment results some immunotherapies. Efficiently blocking reversing key goal enhancement This study discusses characteristics, mechanism, expression strategies.
Язык: Английский
Процитировано
15
BMJ Open, Год журнала: 2025, Номер 15(1), С. e095392 - e095392
Опубликована: Янв. 1, 2025
Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which intestinal microbiome proposed contribute. Pilot studies faecal microbiota transplantation (FMT) in PSC IBD are demonstrated be safe associated with increased bacterial diversity. However, longevity such changes impact on markers activity progression have not been studied. aim this clinical trial determine effects repeated FMT as a treatment for PSC-IBD. FAecal micRobiota primary sclerosinG chOlangitis (FARGO) phase IIa randomised placebo-controlled assess efficacy safety colonic administration patients non-cirrhotic Fifty-eight will recruited from six sites across England 1:1 ratio active or placebo arms. manufactured by University Birmingham Microbiome Treatment Centre, using stool collected rigorously screened healthy donors. A total 8 weekly treatments delivered; first through colonoscopic (week 1) remaining seven via once-weekly enema (up week 8). Participants then followed 12-weekly basis until 48 visit. outcome effect serum alkaline phosphatase values over time (end study at weeks). Key secondary outcomes evaluate other biochemical parameters, risk scores, circulating imaging fibrosis, health-related quality life measures, incidence PSC-related events. translational objectives identify mucosal metagenomic, metatranscriptomic, metabolomic immunological pathways FMT. protocol was approved South Central-Hampshire B Research Ethics Committee (REC 23/SC/0147). required provide written informed consent. results disseminated national international presentations peer-reviewed publications. registered ClinicalTrials.gov 23 February 2024 (NCT06286709). Weblink: Study Details | Microbiota Transplantation primaRy ClinicalTrials.gov.
Язык: Английский
Процитировано
1
Environmental Microbiology, Год журнала: 2024, Номер 26(7)
Опубликована: Июль 1, 2024
Abstract Just as the human gut microbiome is colonized by a variety of microbes, so too rhizosphere plants. An imbalance in this microbial community, known dysbiosis, can have negative impact on plant health. This study sought to explore effect dysbiosis health tomato plants ( Solanum lycopersicum L.), using them and foliar bacterial spot pathogen Xanthomonas perforans model organisms. The rhizospheres 3‐week‐old were treated with either streptomycin or water control, then spray‐inoculated X. after 24 h. Half that both received soil transplants from uninfected donors 48 h was applied. showed 26% increase disease severity compared those did not receive antibiotic. However, transplant exhibited an intermediate level severity. antibiotic‐treated demonstrated reduced abundance rhizobacterial taxa such Cyanobacteria genus Cylindrospermum . They also down‐regulation genes related primary secondary metabolism, up‐regulation defence associated induced systemic resistance. highlights vital role beneficial microbes play resistance, even against pathogens.
Язык: Английский
Процитировано
7
Epigenomics, Год журнала: 2024, Номер 16(6), С. 403 - 418
Опубликована: Фев. 27, 2024
Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. The occurrence CRC associated with various genetic and epigenetic mutations in intestinal epithelial cells that transform them into adenocarcinomas. There increasing evidence indicating the gut microbiota plays crucial role regulation host physiological processes. Alterations composition are responsible for initiating carcinogenesis through diverse modifications, including histone ncRNAs DNA methylation. This work was designed to comprehensively review recent findings provide insight associations between at an level. These scientific insights can be used future develop effective strategies early detection treatment CRC.
Язык: Английский
Процитировано
6
Cancer Letters, Год журнала: 2022, Номер 554, С. 216031 - 216031
Опубликована: Дек. 6, 2022
Язык: Английский
Процитировано
28
International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(8), С. 7261 - 7261
Опубликована: Апрель 14, 2023
Trillions of microbes in the human intestinal tract, including bacteria, viruses, fungi, and protozoa, are collectively referred to as gut microbiome. Recent technological developments have led a significant increase our understanding It has been discovered that microbiome affects both health progression diseases, cancer heart disease. Several studies indicated microbiota may serve potential target therapy modulation, by enhancing effectiveness chemotherapy and/or immunotherapy. Moreover, altered composition linked long-term effects therapy; for example, deleterious on microbial diversity can, turn, lead acute dysbiosis serious gastrointestinal toxicity. Specifically, relationship between cardiac diseases patients following is poorly understood. In this article, we provide summary role treatment, while also speculating connection treatment-related changes cardiotoxicity. Through brief review literature, further explore which bacterial families or genera were differentially affected treatment A deeper link cardiotoxicity caused help lower risk critical potentially fatal side effect.
Язык: Английский
Процитировано
16
Pathogens, Год журнала: 2023, Номер 12(6), С. 766 - 766
Опубликована: Май 26, 2023
In a mutually beneficial connection with its host, the gut microbiota affects host's nutrition, immunity, and metabolism. An increasing number of studies have shown links between certain types disease dysbiosis or specific microorganisms. Fecal transplantation (FMT) is strongly advised for treatment recurrent resistant Clostridium difficile infection (CDI) due to outstanding clinical effectiveness against CDI. The therapeutic potential FMT other disorders, particularly inflammatory bowel diseases malignancies, currently gaining more attention. We summarized most recent preclinical evidence show promise in management cancer as well complications related after reviewing research on relationship cancer.
Язык: Английский
Процитировано
14