Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 1006 - 1021
Опубликована: Фев. 1, 2025
Язык: Английский
International Immunopharmacology, Год журнала: 2024, Номер 142, С. 113056 - 113056
Опубликована: Авг. 31, 2024
Язык: Английский
Процитировано
9
International Journal of Molecular Medicine, Год журнала: 2025, Номер 55(3)
Опубликована: Янв. 8, 2025
Exosomes are integral to the pathophysiology of osteoarthritis (OA) due their roles in mediating intercellular communication and regulating inflammatory processes. transport bioactive molecules, such as proteins, lipids nucleic acids, which can influence chondrocyte behavior joint homeostasis. Given properties regeneration ability target damaged tissues, exosomes represent a promising therapeutic avenue for OA treatment. have potential promoting cartilage repair, reducing inflammation improving overall function. However, several challenges remain, including need standardized isolation characterization methods, variability exosomal content, regulatory hurdles. The present review aims provide comprehensive overview current understanding exosome mechanisms potential, while also addressing ongoing faced translating these findings into clinical practice. By consolidating existing research, pave way future studies aimed at optimizing exosome‑based therapies effective management.
Язык: Английский
Процитировано
1
Frontiers in Pharmacology, Год журнала: 2025, Номер 15
Опубликована: Янв. 13, 2025
Resveratrol, a polyphenolic compound known for its diverse biological activities, has demonstrated multiple pharmacological effects, including anti-inflammatory, anti-aging, anti-diabetic, anti-cancer, and cardiovascular protective properties. Recent studies suggest that these effects are partly mediated through the regulation of macrophage polarization, wherein macrophages differentiate into pro-inflammatory M1 or anti-inflammatory M2 phenotypes. Our review highlights how resveratrol modulates polarization various signaling pathways to achieve therapeutic effects. For example, can activate senescence-associated secretory phenotype (SASP) pathway inhibit signal transducer activator transcription (STAT3) sphingosine-1-phosphate (S1P)-YAP axes, promoting suppressing thereby inhibiting tumor growth. Conversely, it promote suppress by NF-κB activating PI3K/Akt AMP-activated protein kinase (AMPK) pathways, thus alleviating inflammatory responses. Notably, effect on is concentration-dependent; moderate concentrations tend while higher may favor polarization. This concentration dependence offers new perspectives clinical treatment but also underscores necessity precise dosage control when using resveratrol. In summary, exhibits significant potential in regulating treating related diseases.
Язык: Английский
Процитировано
1
Medicine, Год журнала: 2025, Номер 104(4), С. e41335 - e41335
Опубликована: Янв. 24, 2025
Osteoarthritis (OA) is a chronic joint condition affecting millions worldwide, characterized by the gradual degeneration of cartilage, leading to pain, stiffness, and functional impairment. Although pathogenesis OA not fully understood, roles inflammation, metabolic dysregulation, biomechanical stress are increasingly recognized. Current treatments, including pharmacotherapy, physical therapy, surgical interventions, aim alleviate symptoms improve quality life, yet they face limitations challenges. In recent years, researchers have explored variety new treatment strategies, such as molecular targeted biologic regenerative medicine, lifestyle modifications, aiming directly address root causes complex mechanisms OA. This review aims summarize latest research advancements provide fresh perspectives for clinical lay foundation future development strategies
Язык: Английский
Процитировано
1
Journal of Controlled Release, Год журнала: 2025, Номер 379, С. 1006 - 1021
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
1