Identification of exosome-related gene signature as a promising diagnostic and therapeutic tool for breast cancer

Heliyon, Год журнала: 2024, Номер 10(8), С. e29551 - e29551

Опубликована: Апрель 1, 2024

Exosomes are promising tools for the development of new diagnostic and therapeutic approaches. possess ability to activate signaling pathways that contribute remodeling tumor microenvironment, angiogenesis, regulation immune responses. We aimed develop a prognostic score based on exosomes derived from breast cancer.

Язык: Английский

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DDIT3 is associated with breast cancer prognosis and immune microenvironment: an integrative bioinformatic and immunohistochemical analysis

Journal of Cancer, Год журнала: 2024, Номер 15(12), С. 3873 - 3889

Опубликована: Янв. 1, 2024

DNA damage-inducible transcript 3 (DDIT3) is a transcription factor central to apoptosis, differentiation, and stress response. DDIT3 has been extensively studied in cancer biology. However, its precise implications breast progression interaction with the immune microenvironment are unclear. In this study, we utilized novel multi-omics integration strategy, combining bulk RNA sequencing, single-cell spatial transcriptomics immunohistochemistry, explore role of establish correlation between poor prognosis patients. We identified robust prognostic signature, including six genes (unc-93 homolog B1, TLR signaling regulator, anti-Mullerian hormone, DCTP pyrophosphatase 1, mitochondrial ribosomal protein L36, nuclear erythroid 2, Rho GTPase activating 39), associated DDIT3. This signature stratified high-risk patient groups, characterized by increased infiltration regulatory T cells M2-like macrophages fibroblast growth (FGF)/FGF receptor activation. Notably, group demonstrated enhanced sensitivity immunotherapy, presenting therapeutic opportunities. Integrating data helped determine expression pattern tumor cell infiltration. multi-dimensional analysis provided comprehensive understanding intricate interplay cancer. Overall, our study not only facilitates but also offers innovative insights for developing models strategies. Identifying DDIT3-related association promising avenue personalized treatment.

Язык: Английский

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Machine learning developed immune-related exosome signature for prognosis and immunotherapy benefit in bladder cancer

Discover Oncology, Год журнала: 2025, Номер 16(1)

Опубликована: Апрель 18, 2025

Bladder cancer is one of the most common malignancies with high invasion and poor clinical outcome. Exosomes exert a vital role in tumor development, drug resistance, immunotherapy response. Based on datasets from TCGA, GSE13507, GSE31684, GSE32984 GSE48276, immune-related exosome signature (IES) was developed an integrative analysis procedure containing 10 machine learning methods. To investigate performance IES predicting benefit, three (GSE91061, GSE78220 IMvigor210) several scores were used. The RSF + Enet (alpha = 0.2) algorithm-based considered as optimal it had highest average C-index 0.75. presented powerful survival outcome bladder patients their AUC 1-, 3- 5-year ROC curve 0.711, 0.751 0.806 TCGA dataset. A lower level immune-activated cells function, higher immune dysfunction exclusion score, escape intratumor heterogeneity score PD1&CTLA4 immunophenoscore, mutational burden obtained suggesting less benefits. Moreover, cases related hallmark score. current study cancer, which acted indicator for benefits patients.

Язык: Английский

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Roles of extracellular vesicles in glioblastoma: foes, friends and informers

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Ноя. 24, 2023

Glioblastoma (GB) tumors are one of the most insidious cancers which take over brain and defy therapy. Over time in response to treatment tumor cells microenvironment (TME) undergo many genetic/epigenetic driven changes their phenotypes this is reflected cellular contents within extracellular vesicles (EVs) they produce. With result that some EVs try subdue (friends brain), while others participate glioblastoma takeover (foes brain) a dynamic ever changing process. Monitoring these biofluids can inform decisions based on GB status guide therapeutic intervention. This review covers primarily recent research describing different cell types brain, as well cells, EV deluge. includes produced by manipulate transcriptome normal environment support growth (foes), responses restrict invasion, including traveling cervical lymph nodes present neo-antigens dendritic (DCs). In addition released into report living via cargo thus serving biomarkers. However, influence major factor immune suppression coercion join “band wagon”. Efforts being made deploy vehicles for drugs small inhibitory RNAs. Increasing knowledge about TME utilized track progression therapy even weaponize fight tumor.

Язык: Английский

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Function of Long Noncoding RNAs in Glioma Progression and Treatment Based on the Wnt/β-Catenin and PI3K/AKT Signaling Pathways

Cellular and Molecular Neurobiology, Год журнала: 2023, Номер 43(8), С. 3929 - 3942

Опубликована: Сен. 25, 2023

Язык: Английский

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