Bacille-Calmette-Guerin modulates human macrophage and dendritic cell response to SARS-CoV-2 S-glycoprotein DOI Creative Commons

Regina C. Ambe,

Shubhang Bhalla, Alejandra Alvarado

и другие.

Infectious Medicine, Год журнала: 2023, Номер 2(3), С. 241 - 245

Опубликована: Сен. 1, 2023

Given that epidemiological evidence suggests a potential protective role for Bacille-Calmette-Guerin against COVID-19, we aimed to explore whether pre-exposure of human monocyte-derived macrophages and dendritic cells BCG could modulate their response SARS-CoV-2 S-glycoprotein.Dual THP-1 containing 2 reporter plasmids transcription factors NF-κB, IRF were differentiated into over 3 days using phorbol 12-myristate 13-acetate, or 6 commercial monocyte-dencritic cell differentiation media matured with recombinant tumor necrosis factor-α. Cells exposed 24 h then stimulated S-glycoprotein hours.Pre-exposure DCs increased NF-kb activation in the S-glycoprotein.Our results showed both types exhibited an increase inflammatory upon stimulation S-glycoprotein. BCG-induced trained immunity may be important tool reducing susceptibility infection severity COVID-19. Our findings help design future BCG-based therapeutic approaches treatment diseases caused by viral infections.

Язык: Английский

Beyond Tuberculosis: The Surprising Immunological Benefits of the Bacillus Calmette–Guérin (BCG) Vaccine in Infectious, Auto-Immune, and Inflammatory Diseases DOI Creative Commons
Margarita Jurczak, Magdalena Druszczyńska

Pathogens, Год журнала: 2025, Номер 14(2), С. 196 - 196

Опубликована: Фев. 15, 2025

The Bacillus Calmette-Guérin (BCG) vaccine, best known for its role in preventing tuberculosis, has recently garnered attention broader immunomodulatory effects. By inducing trained immunity, BCG reprograms innate immune cells, enhancing their responses to various pathogens. This process, driven by epigenetic and metabolic reprogramming, suggests that may have therapeutic potential far beyond tuberculosis. Emerging evidence points benefits conditions such as autoimmune diseases, cancer, viral infections. Furthermore, modulating activity, been proposed reduce chronic inflammation promote tolerance. review delves into the multifaceted of BCG, highlighting a versatile tool managing wide range diseases.

Язык: Английский

Процитировано

1
Trained immunity-based mucosal immunotherapies for the prevention of respiratory infections DOI Creative Commons
Luna Minute, Karla Montalbán‐Hernández,

Laura Bravo-Robles

и другие.

Trends in Immunology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

The devastating impact of respiratory infections demonstrates the critical need for novel prophylactic vaccines. In this opinion article, we advocate bacterial immunotherapies as a complementary tool in our fight against infections. These can activate wide spectrum immunological mechanisms, with trained immunity (TI) being particularly significant. This phenomenon has led to concept immunity-based vaccines (TIbVs), which represent approach vaccinology. We discuss examples TIbVs, including tuberculosis vaccine Bacille Calmette-Guérin (BCG) and polybacterial immunotherapy MV130. From viewpoint, illustrating mode action clinical evidence supports proposal that TIbVs should be considered next-generation confer protection range

Язык: Английский

Процитировано

0
Host–Pathogen Interaction Interface: Promising Candidate Targets for Vaccine-Induced Protective and Memory Immune Responses DOI Creative Commons
Gloria Guillermina Guerrero Manríquez, Vicente Madrid‐Marina, Aurora Martínez-Romero

и другие.

Vaccines, Год журнала: 2025, Номер 13(4), С. 418 - 418

Опубликована: Апрель 16, 2025

Vaccine formulations are a successful strategy against pathogen transmission because vaccine candidates induce effective and long-lasting memory immune responses (B CD4+ T cells) at systemic mucosal sites. Extracellular vesicles of lipoproteins, bioactive compounds from plants invertebrates (sponges) encapsulated in liposomes, glycoproteins can target these The developed mimic microbial pathogens way that successfully links the innate adaptive responses. In addition, vaccines plus adjuvants promote maintain an inflammatory response. this review, we aimed to identify host–pathogen interface as rich source candidate targets for vaccine-induced protective

Язык: Английский

Процитировано

0
Implications of vaccine non-specific effects on licensure of new vaccines DOI
Grant Munkwase

Vaccine, Год журнала: 2024, Номер 42(5), С. 1013 - 1021

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

3
Modulation of Human Macrophages by Plasma from COVID-19 Patients Following BCG Vaccination: BATTLE Trial DOI Creative Commons
Keini Buosi, Mehrsa Jalalizadeh, Aline Maia

и другие.

International Journal of General Medicine, Год журнала: 2024, Номер Volume 17, С. 3107 - 3117

Опубликована: Июль 1, 2024

To analyze the interfering effect of plasma from COVID-19 convalescent adults vaccinated or not with intradermal Bacillus Calmette-Guérin (BCG) on human macrophages.

Язык: Английский

Процитировано

1
Exploring BCG vaccination as a novel approach to prevent recurrent herpes labialis DOI Creative Commons
Wenping Gong, Jingli Du, Zhuang Li

и другие.

EClinicalMedicine, Год журнала: 2023, Номер 65, С. 102279 - 102279

Опубликована: Окт. 17, 2023

According to WHO, approximately 3.7 billion individuals under the age of 50 years (67%) carry herpes simplex virus type 1 (HSV-1), primary cause labialis.1WHO Herpes virus.https://www.who.int/news-room/fact-sheets/detail/herpes-simplex-virusDate accessed: August 25, 2023Google Scholar Although medication can alleviate symptoms, it cannot cure infection and recurrence may occur. The Bacillus Calmette-Guérin (BCG) vaccine is only approved attenuated for tuberculosis prevention. Research suggests that BCG vaccination induces three types non-specific immune responses: trained immunity, heterologous anti-inflammatory effects.2Parmar K. Siddiqui A. Nugent calmette-guerin nonspecific immunity.Am J Med Sci. 2021; 361: 683-689https://doi.org/10.1016/j.amjms.2021.03.003Summary Full Text PDF PubMed Scopus (12) Google Scholar,3Gong W. Mao Y. Li Qi Vaccination: a potential tool against COVID-19 COVID-19-like Black Swan incidents.Int Immunopharm. 2022; 108108870https://doi.org/10.1016/j.intimp.2022.108870Crossref (10) These responses have been used prevent treat range diseases, including HSV-1, human papillomavirus, COVID-193Gong Scholar, 4Pittet L.F. Curtis N. Does bacillus recurrences? A systematic review.Rev Virol. 31: 1-9https://doi.org/10.1002/rmv.2151Crossref 5Du J. Su Wang R. et al.Research progress on specific effects possibility protection COVID-19.Front Immunol. 2023; 141118378https://doi.org/10.3389/fimmu.2023.1118378Crossref (2) 6Blok B.A. Arts R.J.W. van Crevel al.Differential induced by vi polysaccharide typhoid fever vaccination: an explorative randomized trial.Eur Clin Microbiol Infect Dis. 2020; 39: 1177-1184https://doi.org/10.1007/s10096-020-03813-yCrossref (Fig. 1). In eClinicalMedicine, Laure F Pittet colleagues published their phase 3 clinical trial was conducted across multiple countries assess impact recurrent labialis.7Pittet Moore C.L. McDonald E. al.Bacillus labialis: nested randomised controlled trial.eClinicalMedicine. 64102203https://doi.org/10.1016/j.eclinm.2023.102203Summary (0) 84 patients with frequent episodes labialis were enrolled randomly assigned either group (n = 38) or control 46). results demonstrated that, over 1-year follow-up period, experienced reduced duration, frequency, severity, quality life related than did group. Furthermore, in BCG-immunised individuals, time first extended 1.55 months compared (p 0.02), indicating benefits 0.003). Subgroup analysis revealed primarily observed male participants. 2020 review also 78% adult genital labialis, 37% experiencing long-term remission reduction outbreak frequency severity 41%.4Pittet these differ from 1985 observational M Douglas colleagues—which found not significantly reduce rate prolong recurrence8Douglas J.M. Vontver L.A. Stamm W.E. al.Ineffectiveness toxicity prevention herpes.Antimicrob Agents Chemother. 1985; 27: 203-206https://doi.org/10.1128/aac.27.2.203Crossref Scholar—discrepancies be attributed variations sample size, types, dosage, administration methods, immunological status genetic backgrounds recipients. cautious interpretation necessary, limitations are acknowledged study authors manuscript. Firstly, had relatively small 38 receiving 46 non-vaccinated Secondly, participants' during period taken into consideration. If participants compromised system study, recipients regained antiviral leading reactivation latent viruses subsequent labialis. Therefore, recommended quantity cells function before after vaccination. Thirdly, despite authors' presentation history, (TB) tuberculin skin test (TST) obtained through questioning Table Pittet, L.F′ study,7Pittet screened Mycobacterium (MTB) using TST interferon gamma release assay (IGRA) methods. This lack screening obscured MTB at enrollment. For example, 1992 investigate effectiveness single intradermal injection Tine test-negative excluded factors such as (LTBI) reinoculation BCG.9Hippmann G. Wekkeli M. Rosenkranz A.R. Jarisch Götz [Nonspecific stimulation recidivans. Follow-up 5 10 vaccination].Wien Klin Wochenschr. 1992; 104: 200-204PubMed 109 virus, who tested negative test, received vaccine, own condition serving control. Following vaccination, all remained free minimum 4–6 months. During follow-up, 21 (19%) (9%) experience outbreaks 6 years.9Hippmann findings suggest enrollment trials evaluating protective effect useful improving accuracy results. We strongly advise any aiming immunoprotective should rigorously screen method low TB prevalence areas IGRA high areas. It important note other non-tuberculous mycobacterial infections elicit similar BCG, potentially influencing evaluation treatment efficacy.10Gong Liu Xue Zhuang L. Two issues noted when designing evaluate 141207212https://doi.org/10.3389/fimmu.2023.1207212Crossref Nonetheless, unique innovative contribution literature. between sexes suggested increased risk cold sore occurrence following vaccination.7Pittet imply BCG-induced enhance body's response, but they exacerbate existing inflammatory immune-related diseases. utilising disease treatment, population's state underlying diseases considered. Well-designed studies necessary avoid adverse meticulous conducted, maximising beneficial various BCG. WPG JLD conceptualised this work. LZ analysed data. responsible writing work, revisions XQW. XQW acquired funding. All reviewed final has research funding National Key Development Program China (grant No. 2022YFA1303503), payments made her institution. Eighth Medical Center PLA General Hospital number MS202211002), his XQW, WPG, currently serve executive members Chinese Antituberculosis Association without payments. work funded 2022YFA1303503) MS202211002). funders involved capacity regards data collection, analysis, interpretation, design, patient recruitment, aspect crucial study. impeded accessing willingly assume responsibility its submission publication. trialBCG-Denmark particularly males recurrences, increase sore. Full-Text Open Access

Язык: Английский

Процитировано

2
Bacille-Calmette-Guerin modulates human macrophage and dendritic cell response to SARS-CoV-2 S-glycoprotein DOI Creative Commons

Regina C. Ambe,

Shubhang Bhalla, Alejandra Alvarado

и другие.

Infectious Medicine, Год журнала: 2023, Номер 2(3), С. 241 - 245

Опубликована: Сен. 1, 2023

Given that epidemiological evidence suggests a potential protective role for Bacille-Calmette-Guerin against COVID-19, we aimed to explore whether pre-exposure of human monocyte-derived macrophages and dendritic cells BCG could modulate their response SARS-CoV-2 S-glycoprotein.Dual THP-1 containing 2 reporter plasmids transcription factors NF-κB, IRF were differentiated into over 3 days using phorbol 12-myristate 13-acetate, or 6 commercial monocyte-dencritic cell differentiation media matured with recombinant tumor necrosis factor-α. Cells exposed 24 h then stimulated S-glycoprotein hours.Pre-exposure DCs increased NF-kb activation in the S-glycoprotein.Our results showed both types exhibited an increase inflammatory upon stimulation S-glycoprotein. BCG-induced trained immunity may be important tool reducing susceptibility infection severity COVID-19. Our findings help design future BCG-based therapeutic approaches treatment diseases caused by viral infections.

Язык: Английский

Процитировано

1