Trends in Food Science & Technology, Год журнала: 2025, Номер unknown, С. 105001 - 105001
Опубликована: Апрель 1, 2025
Язык: Английский
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Фев. 6, 2024
Abstract The changes in T regulatory cell (Treg) and helper (Th) 17 ratios holds paramount importance ensuring internal homeostasis disease progression. Recently, novel subsets of Treg Th17, namely IL-17-producing IL-10-producing Th17 have been identified. are widely considered as the intermediates during Treg/Th17 transformation. These “bi-functional” cells exhibit plasticity demonstrated with important roles multiple physiological functions processes. Yin Yang represent opposing aspects phenomena according to ancient Chinese philosophy “Yin-Yang” theory. Furthermore, can transform into Yang, vice versa, under specific conditions. This theory has used describe contrasting immune molecules. Therefore, immune-activating populations (Th17, M1 macrophage, etc.) overreaction (inflammation, autoimmunity) be while immunosuppressive (Treg, M2 immunosuppression (tumor, immunodeficiency) Yin. However, another connotation theory, conversion between rarely documented studies. discovery enriches meaning further promotes relationship modern immunology. Besides, illustrating mechanisms governing their differentiation provides valuable insights underlying dynamically changing statement health diseases.
Язык: Английский
Процитировано
17
The Science of The Total Environment, Год журнала: 2024, Номер 937, С. 173305 - 173305
Опубликована: Май 20, 2024
Heat stress (HS) poses a substantial challenge to livestock. Studies have demonstrated that HS reduces fertility and leads gut microbiota dysbiosis in bulls. However, the impact of on bulls during is still unclear. Our research revealed exposure decreased semen quality bulls, fecal transplantation (FMT) from heat-stressed recipient mice resulted significant decrease number testicular germ cells epididymal sperm. Untargeted metabolomics methodology 16S rDNA sequencing conjoint analysis Akkermansia muciniphila (A. muciniphila) seemed be key bacterial regulator spermatogenesis after exposure. Moreover, indicated A. regulated secondary bile acid metabolism by promoting colonization salt hydrolase (BSH)-metabolizing bacteria, leading increase retinol absorption host subsequently elevation retinoic level, thereby improving spermatogenesis. This study sheds light relationship between HS-induced spermatogenesis, offering potential therapeutic approach for addressing bull spermatogenic dysfunction triggered
Язык: Английский
Процитировано
11
Pharmaceuticals, Год журнала: 2024, Номер 17(5), С. 604 - 604
Опубликована: Май 8, 2024
The involvement of the gut microbiota in anti-cancer treatment has gained increasing attention. Alterations to structure and function bacteria are important factors development cancer as well efficacy chemotherapy. Recent studies have confirmed that related metabolites influence pharmacological activity chemotherapeutic agents through interactions with immune system. This review aims summarize current knowledge how malignant tumor chemotherapy affect microbiota, regulates host response, between response advances strategies for efficiency based on also described. Deciphering complex homeostasis maintained by immunity provides a solid scientific basis bacterial intervention
Язык: Английский
Процитировано
9
Frontiers in Endocrinology, Год журнала: 2025, Номер 15
Опубликована: Янв. 9, 2025
Non-alcoholic fatty liver disease (NAFLD) is a multisystem metabolic disorder, marked by abnormal lipid accumulation and intricate inter-organ interactions, which contribute to systemic imbalances. NAFLD may progress through several stages, including simple steatosis (NAFL), non-alcoholic steatohepatitis (NASH), cirrhosis, potentially cancer. This closely associated with disorders driven overnutrition, key pathological processes dysregulation, impaired autophagy, mitochondrial dysfunction, endoplasmic reticulum (ER) stress, local inflammation. While hepatic metabolism in well-documented, further research into communication mechanisms crucial for deeper understanding of progression. review delves intrahepatic networks tissue-specific signaling mediators involved pathogenesis, emphasizing their impact on distal organs.
Язык: Английский
Процитировано
1
The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2025, Номер 247, С. 106677 - 106677
Опубликована: Янв. 14, 2025
Язык: Английский
Процитировано
1
Allergology International, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Immune health and metabolic functions are intimately connected via diet the microbiota. cells continuously exposed to a wide range of microbes microbial-derived compounds, with important mucosal systemic ramifications. Microbial fermentation dietary components in vivo generates thousands molecules, some which integral molecular circuitry that regulates immune functions. These turn protect against aberrant inflammatory or hyper-reactive processes promote effector responses quickly eliminate pathogens, such as SARS-CoV-2. Potent tolerance mechanisms should ensure these do not over-react non-pathogenic factors (e.g. food proteins), while maintaining ability respond infectious challenges robust, effective well controlled manner. In this review we examine shape microbiota composition interactions host system, their associations mediated disorders strategies for intervention.
Язык: Английский
Процитировано
1
Biomedicine & Pharmacotherapy, Год журнала: 2023, Номер 168, С. 115606 - 115606
Опубликована: Окт. 7, 2023
Bile acids (BAs) facilitate the absorption of dietary lipids and vitamins have also been identified as signaling molecules involved in regulating their own metabolism, glucose lipid well immunity. Disturbances BA homeostasis are associated with various enterohepatic metabolic diseases, such cholestasis, nonalcoholic steatohepatitis, inflammatory bowel disease, obesity. As a key regulator, nuclear orphan receptor farnesoid X (FXR, NR1H4) precisely regulates by transcriptional regulation genes synthesis, circulation. FXR is widely regarded most potential therapeutic target. Obeticholic acid only agonist approved to treat patients primary biliary cholangitis, but its non-specific activation systemic causes high-frequency side effects. In recent years, developing tissue-specific FXR-targeting drugs has become research highlight. This article provides comprehensive overview role intestine/liver briefly discusses target for treating diseases. These findings provide basis development modulators treatment diseases dysfunction.
Язык: Английский
Процитировано
18
Biochemical Pharmacology, Год журнала: 2024, Номер 225, С. 116313 - 116313
Опубликована: Май 22, 2024
Язык: Английский
Процитировано
7
Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)
Опубликована: Окт. 10, 2023
Abstract Maintenance of internal homeostasis is a sophisticated process, during which almost all organs get involved. Liver plays central role in metabolism and involves endocrine, immunity, detoxification storage, therefore it communicates with distant through such mechanisms to regulate pathophysiological processes. Dysfunctional liver often accompanied by pathological phenotypes organs, including the eyes. Many reviews have focused on crosstalk between gut, brain, heart, kidney, but no attention paid In this review, we summarized intimate connections eyes from three aspects. Epidemiologically, suggest liver-related, potential, protective risk factors for typical eye disease as well indicators connected status. For molecular mechanism aspect, elaborate their inter-organ (glucose, lipid, proteins, vitamin, mineral), (ammonia bilirubin), immunity (complement inflammation regulation) aspect. clinical application part, emphasize latest advances utilizing liver-eye axis diagnosis therapy, involving artificial intelligence-deep learning-based novel diagnostic tools detecting adeno-associated viral vector-based gene therapy method curing blinding disease. We aim focus provide insights into communications help resolve existed clinically significant issues.
Язык: Английский
Процитировано
13
Phytomedicine, Год журнала: 2024, Номер 128, С. 155413 - 155413
Опубликована: Фев. 4, 2024
Язык: Английский
Процитировано
5