Experimental Dermatology,
Год журнала:
2025,
Номер
34(5)
Опубликована: Апрель 29, 2025
ABSTRACT
Immune‐mediated
skin
disorders
arise
from
dysfunctional
immune
responses,
instigating
inflammatory
dermatoses
and
a
reduced
quality
of
life.
The
complex
pathogenesis
likely
involves
genetic
risks,
environmental
triggers
aberrant
activation.
An
emerging
body
evidence
suggests
that
bile
acid
disturbances
may
critically
promote
pathology
in
certain
conditions.
Bile
acids
synthesised
cholesterol
regulate
nutrient
metabolism
cell
function
via
nuclear
receptors
G
protein‐coupled
(GPCRs).
Altered
profiles
receptor
expression
have
been
identified
psoriasis,
atopic
dermatitis
(AD)
autoimmune
blistering
diseases.
Disruptions
signalling
affect
the
metabolic
pathways
linked
to
these
disorders.
Targeting
components
axis
represents
promising
therapeutic
strategy.
This
review
elucidates
intricate
links
between
homeostasis
dysfunction
diseases,
synthesising
targeting
unlock
innovative
avenues.
study
compiles
clinical
experimental
data
revealing
disrupted
composition
various
immune‐mediated
dermatoses,
highlighting
significance
cutaneous
regulation.
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Фев. 6, 2024
Abstract
The
changes
in
T
regulatory
cell
(Treg)
and
helper
(Th)
17
ratios
holds
paramount
importance
ensuring
internal
homeostasis
disease
progression.
Recently,
novel
subsets
of
Treg
Th17,
namely
IL-17-producing
IL-10-producing
Th17
have
been
identified.
are
widely
considered
as
the
intermediates
during
Treg/Th17
transformation.
These
“bi-functional”
cells
exhibit
plasticity
demonstrated
with
important
roles
multiple
physiological
functions
processes.
Yin
Yang
represent
opposing
aspects
phenomena
according
to
ancient
Chinese
philosophy
“Yin-Yang”
theory.
Furthermore,
can
transform
into
Yang,
vice
versa,
under
specific
conditions.
This
theory
has
used
describe
contrasting
immune
molecules.
Therefore,
immune-activating
populations
(Th17,
M1
macrophage,
etc.)
overreaction
(inflammation,
autoimmunity)
be
while
immunosuppressive
(Treg,
M2
immunosuppression
(tumor,
immunodeficiency)
Yin.
However,
another
connotation
theory,
conversion
between
rarely
documented
studies.
discovery
enriches
meaning
further
promotes
relationship
modern
immunology.
Besides,
illustrating
mechanisms
governing
their
differentiation
provides
valuable
insights
underlying
dynamically
changing
statement
health
diseases.
The Science of The Total Environment,
Год журнала:
2024,
Номер
937, С. 173305 - 173305
Опубликована: Май 20, 2024
Heat
stress
(HS)
poses
a
substantial
challenge
to
livestock.
Studies
have
demonstrated
that
HS
reduces
fertility
and
leads
gut
microbiota
dysbiosis
in
bulls.
However,
the
impact
of
on
bulls
during
is
still
unclear.
Our
research
revealed
exposure
decreased
semen
quality
bulls,
fecal
transplantation
(FMT)
from
heat-stressed
recipient
mice
resulted
significant
decrease
number
testicular
germ
cells
epididymal
sperm.
Untargeted
metabolomics
methodology
16S
rDNA
sequencing
conjoint
analysis
Akkermansia
muciniphila
(A.
muciniphila)
seemed
be
key
bacterial
regulator
spermatogenesis
after
exposure.
Moreover,
indicated
A.
regulated
secondary
bile
acid
metabolism
by
promoting
colonization
salt
hydrolase
(BSH)-metabolizing
bacteria,
leading
increase
retinol
absorption
host
subsequently
elevation
retinoic
level,
thereby
improving
spermatogenesis.
This
study
sheds
light
relationship
between
HS-induced
spermatogenesis,
offering
potential
therapeutic
approach
for
addressing
bull
spermatogenic
dysfunction
triggered
Frontiers in Endocrinology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 9, 2025
Non-alcoholic
fatty
liver
disease
(NAFLD)
is
a
multisystem
metabolic
disorder,
marked
by
abnormal
lipid
accumulation
and
intricate
inter-organ
interactions,
which
contribute
to
systemic
imbalances.
NAFLD
may
progress
through
several
stages,
including
simple
steatosis
(NAFL),
non-alcoholic
steatohepatitis
(NASH),
cirrhosis,
potentially
cancer.
This
closely
associated
with
disorders
driven
overnutrition,
key
pathological
processes
dysregulation,
impaired
autophagy,
mitochondrial
dysfunction,
endoplasmic
reticulum
(ER)
stress,
local
inflammation.
While
hepatic
metabolism
in
well-documented,
further
research
into
communication
mechanisms
crucial
for
deeper
understanding
of
progression.
review
delves
intrahepatic
networks
tissue-specific
signaling
mediators
involved
pathogenesis,
emphasizing
their
impact
on
distal
organs.
Allergology International,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 1, 2025
Immune
health
and
metabolic
functions
are
intimately
connected
via
diet
the
microbiota.
cells
continuously
exposed
to
a
wide
range
of
microbes
microbial-derived
compounds,
with
important
mucosal
systemic
ramifications.
Microbial
fermentation
dietary
components
in
vivo
generates
thousands
molecules,
some
which
integral
molecular
circuitry
that
regulates
immune
functions.
These
turn
protect
against
aberrant
inflammatory
or
hyper-reactive
processes
promote
effector
responses
quickly
eliminate
pathogens,
such
as
SARS-CoV-2.
Potent
tolerance
mechanisms
should
ensure
these
do
not
over-react
non-pathogenic
factors
(e.g.
food
proteins),
while
maintaining
ability
respond
infectious
challenges
robust,
effective
well
controlled
manner.
In
this
review
we
examine
shape
microbiota
composition
interactions
host
system,
their
associations
mediated
disorders
strategies
for
intervention.
Journal of Translational Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 20, 2025
spinal
cord
injury
(SCI)
disrupts
the
gut
microbiota,
worsening
injury's
impact.
Fecal
microbiota
transplantation
(FMT)
is
increasingly
recognized
as
a
promising
strategy
to
improve
neural
function
post-SCI,
yet
its
precise
mechanisms
are
still
far
from
clear.
The
present
study
aims
elucidate
how
FMT
influences
motor
recovery
and
underlying
utilizing
SCI
mouse
model.
Mice
with
received
healthy
donors.
We
used
16
S
rRNA
amplicon
sequencing
analyze
alterations
of
microbes.
Pathological
in
tissue,
including
neuronal
survival,
axonal
regeneration,
cell
proliferation,
neuroinflammation,
were
assessed
among
experimental
groups.
Additionally,
RNA
(RNA-seq)
was
explore
relevant
signaling
pathways.
Significant
shifts
composition
following
observed
through
analysis.
On
day
7
group
exhibited
significantly
higher
diversity
compared
ABX
group,
more
closely
resembling
that
mice.
promoted
survival
leading
notable
improvements
control
Immunofluorescence
staining
showed
increased
alleviated
extracellular
matrix
(ECM)
deposition,
diminished
glial
scar
formation,
reduced
inflammation
FMT-treated
RNA-seq
analysis
indicated
induced
transcriptomic
changes
associated
material
metabolism,
ECM
remodeling,
anti-inflammatory
responses.
restored
balance
mice,
mitigated
inflammation,
establishing
an
optimal
environment
for
recovery.
These
findings
demonstrated
may
represent
valuable
approach
enhance
functional
SCI.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
168, С. 115606 - 115606
Опубликована: Окт. 7, 2023
Bile
acids
(BAs)
facilitate
the
absorption
of
dietary
lipids
and
vitamins
have
also
been
identified
as
signaling
molecules
involved
in
regulating
their
own
metabolism,
glucose
lipid
well
immunity.
Disturbances
BA
homeostasis
are
associated
with
various
enterohepatic
metabolic
diseases,
such
cholestasis,
nonalcoholic
steatohepatitis,
inflammatory
bowel
disease,
obesity.
As
a
key
regulator,
nuclear
orphan
receptor
farnesoid
X
(FXR,
NR1H4)
precisely
regulates
by
transcriptional
regulation
genes
synthesis,
circulation.
FXR
is
widely
regarded
most
potential
therapeutic
target.
Obeticholic
acid
only
agonist
approved
to
treat
patients
primary
biliary
cholangitis,
but
its
non-specific
activation
systemic
causes
high-frequency
side
effects.
In
recent
years,
developing
tissue-specific
FXR-targeting
drugs
has
become
research
highlight.
This
article
provides
comprehensive
overview
role
intestine/liver
briefly
discusses
target
for
treating
diseases.
These
findings
provide
basis
development
modulators
treatment
diseases
dysfunction.
Pharmaceuticals,
Год журнала:
2024,
Номер
17(5), С. 604 - 604
Опубликована: Май 8, 2024
The
involvement
of
the
gut
microbiota
in
anti-cancer
treatment
has
gained
increasing
attention.
Alterations
to
structure
and
function
bacteria
are
important
factors
development
cancer
as
well
efficacy
chemotherapy.
Recent
studies
have
confirmed
that
related
metabolites
influence
pharmacological
activity
chemotherapeutic
agents
through
interactions
with
immune
system.
This
review
aims
summarize
current
knowledge
how
malignant
tumor
chemotherapy
affect
microbiota,
regulates
host
response,
between
response
advances
strategies
for
efficiency
based
on
also
described.
Deciphering
complex
homeostasis
maintained
by
immunity
provides
a
solid
scientific
basis
bacterial
intervention
