Опубликована: Янв. 1, 2024
Язык: Английский
Clinical Microbiology Reviews, Год журнала: 2024, Номер 37(2)
Опубликована: Май 8, 2024
SUMMARYGiven the importance of gut microbial homeostasis in maintaining health, there has been considerable interest developing innovative therapeutic strategies for restoring microbiota. One such approach, fecal microbiota transplantation (FMT), is main "whole microbiome replacement" strategy and integrated into clinical practice guidelines treating recurrent
Язык: Английский
Процитировано
45
Oncology Letters, Год журнала: 2024, Номер 27(2)
Опубликована: Янв. 5, 2024
Immune checkpoint inhibitors (ICIs) are commonly utilized in tumor treatment. However, they still have limitations, including insufficient effectiveness and unavoidable adverse events. It has been demonstrated that gut microbiota can influence the of ICIs, although precise mechanism remains unclear. Gut plays a crucial role formation development immune system. their associated metabolites play regulatory balance. Tumor occurrence linked to ability evade recognition destruction by The purpose ICIs treatment is reinitiate system's elimination cells. Thus, system acts as communication bridge between ICIs. Varied composition characteristics result diverse outcomes Certain microbiota‑related also therapeutic efficacy some extent. administration antibiotics before or during diminish effectiveness. utilization probiotics fecal transplantation partially alter outcome present review synthesized previous studies examine association elucidated its factors treatment, offered direction for future research.
Язык: Английский
Процитировано
7
Aging, Год журнала: 2024, Номер 16(4), С. 3596 - 3611
Опубликована: Фев. 15, 2024
Background: The causative implications remain ambiguous. Consequently, this study aims to evaluate the putative causal relationship between gut microbiota and Esophageal cancer (EC). Methods: genome-wide association (GWAS) pertaining microbiome, derived from MiBioGen consortium-which consolidates 18,340 samples across 24 population-based cohorts-was utilized as exposure dataset. Employing GWAS summary statistics specific EC patients sourced Catalog leveraging two-sample Mendelian randomization (MR) methodology, principal analytical method applied was inverse variance weighted (IVW) technique. Cochran's Q statistic discern heterogeneity inherent in data set. Subsequently, a reverse MR analysis executed. Results: Findings IVW technique elucidated that Family Porphyromonadaceae (P = 0.048) Genus Candidatus Soleaferrea function deterrents against development. In contrast, Catenibacterium 0.044), Eubacterium coprostanoligenes group 0.038), Marvinbryantia 0.049), Ruminococcaceae UCG010 0.034), Ruminococcus1 0.047), Sutterella 0.012) emerged prospective risk contributors for EC. To assess effect, we used outcome, revealed associations seven different types of microbiota. robustness findings substantiated through comprehensive pleiotropy evaluations. Conclusions: This research identified certain microbial taxa either protective or detrimental elements EC, potentially offering valuable biomarkers asymptomatic diagnosis therapeutic interventions
Язык: Английский
Процитировано
7
Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Май 7, 2024
Previous studies have indicated a potential link between the gut microbiota and lymphoma. However, exact causal interplay two remains an area of ambiguity.
Язык: Английский
Процитировано
5
Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13
Опубликована: Дек. 12, 2023
Colorectal cancer (CRC) is a common malignancy of the gastrointestinal tract, accounting for second most cause tumors. As one intestinal barriers, gut bacteria form biofilm, participate in work, and living environment cells. Metagenomic next-generation sequencing (mNGS) large number CRC patients has been established, enabling specific microbial signatures to be associated with colorectal adenomato-carcinoma. Gut are involved both benign precursor lesions (polyps), situ growth metastasis CRC. Therefore, term tumorigenic was proposed 2018, such as Escherichia coli , Fusobacterium nucleatum enterotoxigenic Bacteroides fragilis etc. Meanwhile, toxins (such cytolethal distending toxin (CDT), Colibactin (Clb), B. toxin) affect tumor microenvironment promote occurrence immune escape. It important note that there differences different types In this paper, role polyp-cancer transformation effects their secreted on will discussed, thereby further exploring new ideas prevention treatment
Язык: Английский
Процитировано
12
Life Science Alliance, Год журнала: 2024, Номер 7(4), С. e202302529 - e202302529
Опубликована: Фев. 5, 2024
Bidirectional interactions between the immune system and gut microbiota are key contributors to various physiological functions. Immune-associated diseases such as cancer autoimmunity, efficacy of immunomodulatory therapies, have been linked microbiome variation. Although COVID-19 infection has shown cause microbial dysbiosis, it remains understudied whether inflammatory response associated with vaccination also impacts microbiota. Here, we investigate temporal impact on in healthy immuno-compromised individuals; latter included patients primary immunodeficiency immunomodulating therapies. We find that remained remarkably stable post-vaccination irrespective diverse status, vaccine response, composition spanned by cohort. The stability is evident at all evaluated levels including diversity, phylum, species, functional capacity. Our results indicate resilience host changes triggered suggest minimal, if any, microbiome-mediated processes. These findings encourage acceptance, particularly when contrasted significant shifts observed during infection.
Язык: Английский
Процитировано
4
Critical Reviews in Oncology/Hematology, Год журнала: 2024, Номер 203, С. 104480 - 104480
Опубликована: Авг. 22, 2024
Gastrointestinal (GI) cancer continues to pose a significant global health challenge. Recent advances in our understanding of the complex relationship between host and gut microbiota have shed light on critical role metabolic interactions pathogenesis progression GI cancer. In this study, we examined how interact with influence signalling pathways that impact formation tumours. Additionally, investigated potential therapeutic approach manipulating for use clinical settings. Revealing molecular exchanges facilitates deeper underlying mechanisms drive development. Metabolic hold promise identification microbial signatures or associated specific stages Hence, study provides strategies diagnosis, treatment management cancers improve patient outcomes.
Язык: Английский
Процитировано
4
Journal of Translational Medicine, Год журнала: 2024, Номер 22(1)
Опубликована: Сен. 11, 2024
Язык: Английский
Процитировано
4
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116734 - 116734
Опубликована: Июль 17, 2024
Hepatic diseases pose a significant threat to community health, impacting the quality of life and longevity millions worldwide. Despite revolutionary advancements in treatment, liver remain pressing issue, necessitating development more effective therapeutic approaches. Here, we conducted comprehensive multi-omics analysis investigate underlying mechanism Swertiamarin alleviating hepatic injuries induced by CCl
Язык: Английский
Процитировано
3
Gut, Год журнала: 2024, Номер unknown, С. gutjnl - 333530
Опубликована: Дек. 9, 2024
Natural killer/T-cell lymphoma (NKTCL) is a highly aggressive malignancy with dismal prognosis, and gaps remain in understanding the determinants influencing disease outcomes. To characterise gut microbiota feature identify potential probiotics that could ameliorate development of NKTCL. This cross-sectional study employed shotgun metagenomic sequencing to profile two Chinese NKTCL cohorts, validation conducted an independent Korean cohort. Univariable multivariable Cox proportional hazards analyses were applied assess associations between identified marker species patient Tumour-suppressing effects investigated using comprehensive vivo vitro models. In addition, metabolomics, RNA sequencing, chromatin immunoprecipitation Western blot analysis, immunohistochemistry lentiviral-mediated gene knockdown system used elucidate underlying mechanisms. We first unveiled significant dysbiosis patients, prominently marked by notable reduction Faecalibacterium prausnitzii which correlated strongly shorter survival among patients. Subsequently, we substantiated antitumour properties F. mouse Furthermore, culture supernatant demonstrated efficacy inhibiting cell growth. Metabolomics analysis revealed butyrate as critical metabolite these tumour-suppressing effects, validated three human lines multiple tumour-bearing Mechanistically, suppressed activation Janus kinase-signal transducer activator transcription pathway through enhancing histone acetylation, promoting expression suppressor cytokine signalling 1. These findings uncover distinctive provide novel perspective on leveraging therapeutic this malignancy.
Язык: Английский
Процитировано
3