Recent Advances in the Treatment of Spinal Cord Injury.

PubMed, Год журнала: 2024, Номер 12(6), С. 380 - 399

Опубликована: Янв. 1, 2024

Spinal cord injury (SCI) is a complex, multifaceted, progressive, and yet incurable complication that can cause irreversible damage to the individual, family, society. In recent years strategies for management rehabilitation of SCI besides axonal regeneration, remyelination, neuronal plasticity injured spinal have significantly improved. Although most current research therapeutic advances been made in animal models, so far, no specific complete treatment has reported humans. The failure treat this due inherent neurological complexity structural, cellular, molecular, biochemical characteristics injury. review, addition elucidating causes from molecular pathophysiological perspective, drawbacks neural regeneration lead are described. Also, cutting-edge areas presented.

Язык: Английский

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Sacral Bioneuromodulation: The Role of Bone Marrow Aspirate in Spinal Cord Injuries

Bioengineering, Год журнала: 2024, Номер 11(5), С. 461 - 461

Опубликована: Май 6, 2024

Spinal cord injury (SCI) represents a severe trauma to the nervous system, leading significant neurological damage, chronic inflammation, and persistent neuropathic pain. Current treatments, including pharmacotherapy, immobilization, physical therapy, surgical interventions, often fall short in fully addressing underlying pathophysiology resultant disabilities. Emerging research field of regenerative medicine has introduced innovative approaches such as autologous orthobiologic therapies, with bone marrow aspirate (BMA) being particularly notable for its anti-inflammatory properties. This review focuses on potential BMA modulate inflammatory pathways, enhance tissue regeneration, restore function disrupted by SCI. We hypothesize that BMA’s bioactive components may stimulate reparative processes at cellular level, when applied strategic sites like sacral hiatus influence lumbar centers higher structures. By exploring mechanisms through which influences spinal repair, this aims establish foundation application clinical settings, potentially offering transformative approach SCI management extends beyond symptomatic relief promoting functional recovery.

Язык: Английский

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HGF Facilitates the Repair of Spinal Cord Injuries by Driving the Chemotactic Migration of MSCs Through the β-Catenin/TCF4/Nedd9 Signaling Pathway

Stem Cells, Год журнала: 2024, Номер 42(11), С. 957 - 975

Опубликована: Сен. 12, 2024

Abstract Transplanted mesenchymal stem cells (MSCs) can significantly aid in repairing spinal cord injuries (SCIs) by migrating to and settling at the injury site. However, this process is typically inefficient, as only a small fraction of MSCs successfully reach target lesion area. During SCI, increased expression secretion hepatocyte growth factor (HGF) act chemoattractant that guides MSC migration. Nonetheless, precise mechanisms which HGF influences migration are not fully understood. This study focused on unraveling molecular pathways drive toward SCI site response HGF. It was found activate β-catenin signaling either phosphorylating LRP6, suppressing GSK3β phosphorylation through AKT ERK1/2 pathways, or enhancing nuclear translocation TCF4. activation leads elevated Nedd9 expression, promotes focal adhesion formation F-actin polymerization, facilitating chemotactic Transplanting during peak injured tissues substantially improves nerve regeneration, reduces scarring, enhances hind limb mobility. Additionally, prolonging release further boost engraftment, thereby amplifying regenerative outcomes. inhibiting HGF/Met interfering with impairs obstructing tissue repair functional recovery. Together, these findings provide theoretical basis practical strategy for transplantation therapy highlighting specific regulates MSCs, ultimately triggering their

Язык: Английский

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Therapeutic potential of mesenchymal stem cell-derived exosomes and miRNAs in neuronal regeneration and rejuvenation in neurological disorders: a mini review

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Окт. 4, 2024

Mesenchymal stem cells (MSCs) have gained considerable attention in the field of regenerative medicine due to their ability secrete small extracellular vesicles (EVs) known as exosomes. This review delves into various biological activities MSCs and cell interactions enabled by these exosomes, with a focus on potential for neuronal regeneration treatment neurological disorders. We scrutinize findings from multiple studies that underscore neuroprotective neuro-regenerative effects exosomes derived MSCs, illuminating mechanisms action therapeutic applications. thoroughly investigates all related pathways, miRNAs, factors suggest strategies enhancing therapy disorders using boosting regeneration.

Язык: Английский

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The global state of research in stem cells therapy for spinal cord injury (2003–2022): a visualized analysis

Frontiers in Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Янв. 24, 2024

Objective Our study aimed to visualize the global status and frontiers in stem cell therapy for spinal cord injury by using bibliometric methodology. Methods Publication citation information related (SCI) studies between 2003 2022 was retrieved from Web of Science Core Collection database. For visualized study, VOS viewer software Graph Pad Prism 9.5 were used perform analysis included data publication number statistics SCI domain. Results A total 6,686 publications retrieved. The USA China made highest contributions research with citations link strength. journal Experimental Neurology ranks as top journal, combining amount bibliometrics results. University Toronto, based Canada, first-ranking institution. directions current could be divided into five clusters. Transplantation Regenerative Medicine Neurosciences Mechanism Research may emerging this Conclusion In summary, injuries is poised more valuable advances.

Язык: Английский

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