Cancer Cell International, Год журнала: 2024, Номер 24(1)

Опубликована: Авг. 8, 2024

The Gasdermin E gene (GSDME) plays roles in deafness and cancers. However, the mechanisms cancers are complex, same exhibits different actions types of Online databases, such as GEPIA2, cBioPortal, DNMIVD, were used to comprehensively analyze GSDME profiles, DNA methylations, mutations, diagnosis, prognosis patients with tumor tissues matched healthy tissues. Western blotting RT-PCR monitor regulation by Cordycepin (CD) cancer cell lines. We revealed that expression is significantly upregulated eight (ACC, DLBC, GBM, HNSC, LGG, PAAD, SKCM, THYM) downregulated seven (COAD, KICH, LAML, OV, READ, UCES, UCS). overall survival was longer only ACC, but shorter four cancers, including COAD, KIRC, LIHC, STAD, when highly expressed compared corresponding normal Moreover, high negatively correlated poor while low suggesting might serve a good prognostic factor these two types. Accordingly, results indicated methylations those 7 CpG sites constitute potentially effective signature distinguish tumors from adjacent Gene mutations for frequently observed variety tumors, UCES having highest frequency. CD treatment inhibited lines, overexpression promoted migration invasion. Thus, we have systematically successfully clarified diagnostic values, values pan-cancers. Targeting implies therapeutic significance mechanism antitumor some via increasing sensitivity chemotherapy. Altogether, our study may provide strategy biomarker clinical prognostics, targeting GSDME.

Язык: Английский