Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Авг. 25, 2023
GENERAL COMMENTARY article Front. Immunol., 25 August 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1265565
Язык: Английский
APOPTOSIS, Год журнала: 2024, Номер 29(7-8), С. 981 - 1006
Опубликована: Июнь 2, 2024
Язык: Английский
Процитировано
12
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Июль 27, 2024
Abstract Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity dysbalanced metabolism were associated with disruption intracellular respiration development various diseases, including cancer. Notably, copper-induced cell death was defined as cuproptosis which also observed in malignant cells, representing attractive anti-cancer instrument. Excess copper leads to aggregation lipoylation proteins toxic stress, ultimately resulting activation death. Differential expression cuproptosis-related genes detected tissues. Cuproptosis-related linked regulation oxidative immune responses, composition tumor microenvironment. Activation increased redox-metabolism-regulating genes, such ferredoxin 1 (FDX1), lipoic acid synthetase (LIAS), lipoyltransferase (LIPT1), dihydrolipoamide dehydrogenase (DLD), drolipoamide S-acetyltransferase (DLAT), pyruvate E1 subunit alpha (PDHA1), beta (PDHB)). Accordingly, copper-activated network suggested target cancer therapy. Mechanisms different cancers microenvironment are discussed this study. The analysis current findings indicates that therapeutic signaling, targets may provide effective tool improvement immunotherapy regimens. Graphical
Язык: Английский
Процитировано
8
MedComm, Год журнала: 2024, Номер 5(10)
Опубликована: Сен. 17, 2024
Copper is a vital trace element in human physiology, essential for the synthesis of numerous crucial metabolic enzymes and facilitation various biological processes. Regulation copper levels within narrow range imperative maintaining homeostasis. Numerous studies have demonstrated significant roles homeostasis cuproptosis health disease pathogenesis. However, comprehensive up-to-date systematic review this domain remains absent. This aims to consolidate recent advancements understanding disease, focusing on underlying mechanisms potential therapeutic interventions. Dysregulation homeostasis, manifesting as either excess or deficiency, implicated etiology diseases. Cuproptosis, recently identified form cell death, characterized by intracellular overload. phenomenon mediates diverse array evolutionary processes organisms, spanning from genetic disorders, liver diseases, neurodegenerative cancers. provides summary pathogenic along with associated targeted agents. Furthermore, it explores future research directions yield treatment, management, prevention.
Язык: Английский
Процитировано
7
Journal of Gastroenterology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 31, 2025
Язык: Английский
Процитировано
1
Biology Direct, Год журнала: 2024, Номер 19(1)
Опубликована: Авг. 22, 2024
TSPAN7 is an important factor in tumor progression. However, the precise function of and its role pan-cancer are not clear. Based on Xinhua cohort incorporating 370 patients with kidney neoplasm, we conducted differential expression analysis by immunohistochemistry between normal tissues, explored correlations patients' survival. Subsequently, a study, successively employed analysis, competing endogenous RNA (ceRNA) protein-protein interaction (PPI) correlation clinical characteristics, purity, genomics, immunity, drug sensitivity. Last but least, gene set enrichment was applied to identify enriched pathways TSPAN7. In cohort, significantly up-regulated (P-value = 0.0019) tissues neoplasm patients. High associated decreases overall survival (OS) 0.009) progression-free 0.009), it further revealed as independent risk for OS 0.0326, HR 5.66, 95%CI 1.155–27.8). down-regulated most tumors, survival, The ceRNA network PPI were also constructed. top five various tumors identified. served promising biomarker especially neoplasms, closely immunology, sensitivity level.
Язык: Английский
Процитировано
4
Expert Opinion on Therapeutic Targets, Год журнала: 2024, Номер 28(5), С. 419 - 435
Опубликована: Апрель 30, 2024
Collagen triple helix repeat containing 1 (CTHRC1) is a protein that has been implicated in pro-migratory pathways, arterial tissue-repair processes, and inhibition of collagen deposition via the regulation multiple signaling cascades. Studies have also demonstrated an upregulation CTHRC1 cancers where it linked to enhanced proliferation, invasion, metastasis. However, understanding exact role mechanisms cancer far from complete.
Язык: Английский
Процитировано
3
CPT Pharmacometrics & Systems Pharmacology, Год журнала: 2024, Номер 13(5), С. 837 - 852
Опубликована: Апрель 9, 2024
Abstract The association between memory CD4+ T cells and cancer prognosis is increasingly recognized, but their impact on lung adenocarcinoma (LUAD) remains unclear. In this study, using the cell‐type identification by estimating relative subsets of RNA transcripts algorithm, we analyzed immune cell composition patient survival in LUAD. Weighted gene coexpression network analysis helped identify cell–associated modules. Combined with module genes, a five‐gene LUAD prognostic risk model ( HOXB7 , MELTF ABCC2 GNPNAT1 LDHA ) was constructed regression analysis. validated GSE31210 data set. validation results demonstrated excellent predictive performance scoring model. Correlation conducted clinical information scores samples, revealing that patients disease progression exhibited higher scores. Furthermore, univariate multivariate analyses independent capability. nomogram superior to outperformed individual factors. Immune landscape assessment performed compare different score groups. revealed better low‐risk group infiltration. also showed potential benefits from immunotherapy. Our study proposes as reliable biomarker for personalized treatment patients.
Язык: Английский
Процитировано
1
Computers in Biology and Medicine, Год журнала: 2024, Номер 178, С. 108692 - 108692
Опубликована: Июнь 6, 2024
Язык: Английский
Процитировано
1
Frontiers in Immunology, Год журнала: 2023, Номер 14
Опубликована: Авг. 25, 2023
GENERAL COMMENTARY article Front. Immunol., 25 August 2023Sec. Cancer Immunity and Immunotherapy Volume 14 - 2023 | https://doi.org/10.3389/fimmu.2023.1265565
Язык: Английский
Процитировано
0