International Journal of Retina and Vitreous,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 8, 2025
Abstract
Background
This
study
was
conducted
as
a
retrospective,
exploratory
analysis
to
assess
early
anatomical
and
functional
effects
of
intravitreal
aflibercept
8
mg
in
neovascular
age-related
macular
degeneration
(nAMD)
small
cohort
patients.
Methods
retrospective
at
the
Jules
Gonin
Eye
Hospital
Lausanne,
Switzerland,
included
treatment-naïve
patients
with
nAMD.
Patients
received
minimum
two
injections
(IVT)
over
3-month
period.
Key
outcomes
assessed
were
changes
best-corrected
visual
acuity
(BCVA),
central
subfield
thickness
(CST),
mean
retinal
(RT),
total
fluid
(TF)
volume
which
calculated
sum
intraretinal
(IRF),
subretinal
(SRF)
pigment
epithelial
detachment
(PED)
volumes.
These
parameters
evaluated
baseline,
month
1,
3
using
RetinAI
Discovery
®
platform,
an
artificial
intelligence-based
system.
Results
10
eyes
enrolled.
Mean
age
77.7
±
12.5
years.
Comparative
between
revealed
statistically
significant
reduction
CST,
RT
TF
volume,
indicating
positive
response
treatment.
One
adverse
event
intraocular
inflammation
(IOI)
occurred
one
patient
(10%)
after
second
IVT
injection.
Treatment
subsequently
interrupted,
IOI
resolved
topical
corticosteroids
therapy.
Conclusion
Intravitreal
demonstrated
improvements
nAMD
first
3-months.
The
use
AI-based
allowed
for
detailed
automated
assessment
changes,
providing
valuable
insights
into
treatment
effects.
Given
design
cohort,
further
studies
are
warranted
long-term
potential
predictive
value
on
prognosis
safety.
Clinical
trial
number
Not
applicable.
Macromolecular Symposia,
Год журнала:
2025,
Номер
414(1)
Опубликована: Фев. 1, 2025
Abstract
This
study
includes
measuring
the
concentrations
of
variable's
hormone
ricistin,
interleukin‐6
macromolecules,
and
tumor
necrosis
factor.
A
biochemical
is
conducted
on
100
blood
serum
samples,
70
samples
them
for
patients
with
cardiovascular
diseases
aged
25–70
years
30
are
collected
healthy
people
as
a
control
group
years.
Using
enzyme
linked
immuno
sorbent
asaay
(ELISA).
number
variables
measured
in
groups
this
study.
Furthermore,
result
shows
high
significant
increase
concentration
interleukin‐6,
TNF
at
probability
level
(0.01
≥
p).
These
results
compared
people.
Antioxidants,
Год журнала:
2025,
Номер
14(4), С. 430 - 430
Опубликована: Апрель 2, 2025
Low-density
lipoprotein
(LDL)
chemically
modified
by
reactive
oxygen
species
(ROS),
for
example,
leaking
from
red
blood
cells
in
the
vascular
compartment,
more
readily
crosses
endothelium
than
does
nonoxidatively
LDL
to
enter
tissue
fluid.
Oxidatively
(oxLDL)
may
also
be
created
fluid
ROS
design,
inflammatory
white
cells,
or
simply
other
as
a
consequence
of
metabolism.
As
well
oxLDL,
glycatively
(glycLDL)
is
formed
circulation.
High-density
(HDL)
appears
capable
decreasing
burden
lipid
peroxides
on
exposed
glucose
and
its
metabolites.
The
mechanism
this
that
has
received
most
attention
antioxidant
activity
HDL,
which
due
large
part
presence
paraoxonase
1
(PON1).
PON1
intimately
associated
with
apolipoprotein
A1
component
HDL’s
domains
into
cell
membranes
can
transferred.
It
frequently
overlooked
hydrolyze
substrates,
it
essential
remain
virtue
hydrophobic
amino
acid
sequences
within
micellar
environment,
during
isolation
serum
genetically
culture.
Otherwise,
retain
capacity
water-soluble
such
phenyl
acetate,
whilst
failing
lipid-soluble
molecules.
OxLDL
probably
glycLDL,
once
they
have
crossed
arterial
receptor-mediated
transcytosis,
are
rapidly
taken
up
monocytes
process
involves
scavenger
receptors,
leading
subendothelial
foam
formation.
These
precursors
atheroma,
inducing
cross
lesion
proliferation
migration
myocytes
present
wall
developing
lesion,
where
transform
fibroblasts.
atheroma
progresses
central
extracellular
lake
cholesteryl
ester
following
necrosis
apoptosis
an
overlying
fibrous
cap
continuing
grow
concentrically
around
involving
oxLDL
glycLDL.
Within
wall,
additional
generated
secreted
leakage
generally
when
couplet
reduced.
important
HDL
opposes
atherogenesis,
provide
better
avenue
inquiry
identification
vulnerable
individuals
provision
new
therapies
emerged
emphasis
placed
role
RCT.
International Journal of Retina and Vitreous,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 8, 2025
Abstract
Background
This
study
was
conducted
as
a
retrospective,
exploratory
analysis
to
assess
early
anatomical
and
functional
effects
of
intravitreal
aflibercept
8
mg
in
neovascular
age-related
macular
degeneration
(nAMD)
small
cohort
patients.
Methods
retrospective
at
the
Jules
Gonin
Eye
Hospital
Lausanne,
Switzerland,
included
treatment-naïve
patients
with
nAMD.
Patients
received
minimum
two
injections
(IVT)
over
3-month
period.
Key
outcomes
assessed
were
changes
best-corrected
visual
acuity
(BCVA),
central
subfield
thickness
(CST),
mean
retinal
(RT),
total
fluid
(TF)
volume
which
calculated
sum
intraretinal
(IRF),
subretinal
(SRF)
pigment
epithelial
detachment
(PED)
volumes.
These
parameters
evaluated
baseline,
month
1,
3
using
RetinAI
Discovery
®
platform,
an
artificial
intelligence-based
system.
Results
10
eyes
enrolled.
Mean
age
77.7
±
12.5
years.
Comparative
between
revealed
statistically
significant
reduction
CST,
RT
TF
volume,
indicating
positive
response
treatment.
One
adverse
event
intraocular
inflammation
(IOI)
occurred
one
patient
(10%)
after
second
IVT
injection.
Treatment
subsequently
interrupted,
IOI
resolved
topical
corticosteroids
therapy.
Conclusion
Intravitreal
demonstrated
improvements
nAMD
first
3-months.
The
use
AI-based
allowed
for
detailed
automated
assessment
changes,
providing
valuable
insights
into
treatment
effects.
Given
design
cohort,
further
studies
are
warranted
long-term
potential
predictive
value
on
prognosis
safety.
Clinical
trial
number
Not
applicable.
