Structure-anti-inflammatory activity relationship of garlic fructans in mice with dextran sulfate sodium-induced colitis: Impact of chain length

Carbohydrate Polymers, Год журнала: 2024, Номер 346, С. 122582 - 122582

Опубликована: Авг. 9, 2024

Язык: Английский

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Berberine regulates intestinal microbiome and metabolism homeostasis to treat ulcerative colitis

Life Sciences, Год журнала: 2024, Номер 338, С. 122385 - 122385

Опубликована: Янв. 4, 2024

Язык: Английский

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Persimmon peel polysaccharides alleviated colitis via regulating gut microbiota and protecting intestinal barrier integrity

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106123 - 106123

Опубликована: Фев. 1, 2025

Язык: Английский

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Supplementary Hesperidin Alleviated CPT-11-Induced Diarrhea by Modulating Gut Microbiota and Inhibiting the IL-17 Signaling Pathway

Journal of Agricultural and Food Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Фев. 28, 2025

Irinotecan (CPT-11) is a chemotherapy agent commonly used for the treatment of gastrointestinal tumors, with diarrhea being frequent adverse effect. Hesperidin flavonoid abundant in citrus fruits and has shown potential managing CPT-11-induced (CID). However, mechanisms underlying its effects remain unclear. This study established mouse model CID using CPT-11 administration to evaluate hesperidin on severity, intestinal pathology, gut microbiota composition, metabolite profiles by conducting biochemical analysis, histopathology, immunohistochemistry, 16S rRNA sequencing, untargeted metabolomics. In addition, transcriptomic molecular docking, dynamics simulations were conducted investigate action. supplementation was found significantly alleviate mice. Analysis sequencing revealed that improved microbial key taxa such as Alistipes, Limosilactobacillus, Rikenella, Mucispirillum playing central role ameliorating CID. Furthermore, enhanced barrier function upregulating tight junction proteins, mitigating epithelial damage, reducing expression IL-17A, TARF6, p38, phosphorylated-p38 (P-p38), AP-1 proteins colon. These findings suggest mitigates modulating inhibiting IL-17 signaling pathway, thereby improving integrity.

Язык: Английский

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Exopolysaccharides and Surface-Layer Proteins Expressed by Biofilm-State Lactiplantibacillus plantarum Y42 Play Crucial Role in Preventing Intestinal Barrier and Immunity Dysfunction of Balb/C Mice Infected by Listeria monocytogenes ATCC 19115

Journal of Agricultural and Food Chemistry, Год журнала: 2024, Номер 72(15), С. 8581 - 8594

Опубликована: Апрель 9, 2024

Our previous study showed that Lactiplantibacillus plantarum Y42 in the biofilm state can produce more exopolysaccharides and surface-layer proteins a stronger promoting effect on intestinal barrier function than planktonic state. In this study, oral administration of live/pasteurized or L. its metabolites (exopolysaccharides proteins) increased expression Occludin, Claudin-1, ZO-1, MUC2 gut Balb/C mice after exposure to Listeria monocytogenes ATCC 19115 inhibited activation NLRP3 inflammasome pathway, which turn reduced levels inflammatory cytokines IL-1β IL-18 serum mice. Furthermore, abundance beneficial bacteria (e.g., Lachnospiraceae_NK4A136_group Prevotellaceae_UCG-001) while reducing harmful norank_f__Muribaculaceae) mice, line with increase short-chain fatty acids indole derivatives feces Notably, exerted better preventing dysfunction due fact plantarumY42 expressed These results provide data support for use extracted from biofilm-state as functional food ingredients dysfunction.

Язык: Английский

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Review of the toxic effects and health functions of arecoline on multiple organ systems

Food Innovation and Advances, Год журнала: 2024, Номер 3(1), С. 31 - 41

Опубликована: Янв. 1, 2024

Arecoline, the principal active alkaloid in areca nut, is known for its ability to induce euphoric sensations. Since ancient times, arecoline has garnered attention therapeutic potential addressing psychiatric disorders and alleviating gastrointestinal ailments. However, 2020, International Agency Research on Cancer classified as "probably carcinogenic humans" (Group 2B carcinogen), supported by compelling mechanistic evidence. The mechanism of action been extensively studied, but results these studies are scattered lack systematic integration generalization. In this paper, we have systematically summarized within oral cavity, central nervous system, cardiovascular digestion terms both health functions toxic effects. addition, found some concentration-effect relationship between system digestive i.e., low doses beneficial high harmful. By summarizing mechanisms arecoline, review poised provide in-depth valuable insights into clinical practice targeted therapy future.

Язык: Английский

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Comprehensive insights into areca nut: active components and omics technologies for bioactivity evaluation and quality control

Frontiers in Pharmacology, Год журнала: 2024, Номер 15

Опубликована: Май 30, 2024

Areca nut (AN), the fruit or seed of catechu Linn, has many uses, including chewing and medicinal purposes. It sparked worries about health due to presence alkaloids. Chewing AN may have a variety negative consequences; however, use no notable adverse effects. To completely understand effectively AN, researchers investigated its chemical makeup biological activity, analyzed variations between different species periods, improved extraction processing procedures. Today, an increasing number are exploring underlying reasons for variations, as well molecular mechanisms biosynthesis components, comprehend change at genetic level. This review presents overview clinical study, pharmacology, detection main bioactive components in factors influencing their content, delving into omics applications research. On basis discussions summaries, this identifies current research gaps proposes future directions investigation.

Язык: Английский

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Therapeutic Potential of Vanillic Acid in Ulcerative Colitis Through Microbiota and Macrophage Modulation

Molecular Nutrition & Food Research, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

This study investigated the protective effects of dietary polyphenol vanillic acid (VA) on dextran sulfate sodium-induced acute ulcerative colitis (UC) in mice, focusing its impact gut microbiota and inflammatory responses. VA was supplemented following sodium administration, key indicators, including body weight, disease activity index, colon length, spleen markers, were assessed. supplementation significantly alleviated UC symptoms, preserved intestinal barrier integrity, reduced pro-inflammatory cytokine levels. Additionally, positively altered composition, promoting beneficial bacteria such as Akkermansia muciniphila while suppressing arachidonic metabolism pathway. Fecal transplantation confirmed that VA-modified contributed to these effects. also facilitated macrophage polarization from M1 phenotype anti-inflammatory M2 phenotype, further mitigating inflammation. These findings highlight potential a natural intervention for UC, emphasizing role regulating pathways, which may have significant nutritional relevance managing bowel diseases.

Язык: Английский

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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 303 - 324

Опубликована: Янв. 1, 2025

Huanglian-ejiao decoction (HED) is a Chinese traditional medicinal formula evolved from the Shanghan Lun (Treatise on Febrile Diseases). However, HED ultimate mechanism of action remained indistinct. Therefore, this study aimed to investigate whether could exert anti-inflammatory effects 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through regulation CD4+T subsets and gut microbiota. Fifty-eight major compounds in were identified by UPLC-Q-TOF/MS. The therapeutic efficacy UC was assessed evaluating survival rate so on. Flow cytometry employed assay percentages cell. RT-PCR Western blot took advantage detecting transcription factors, inflammatory tight junction proteins. Transcriptome sequencing performed colon tissue 16S rRNA gene enforced intestinal contents. administration enhanced mice, significantly restored body weight, DAI score, weight index, spleen index. effectively reshaped barrier dysfunction, inhibited ratio Th1 Th2 cells, preserved Th2/Th1 Tregs/Th17 balance. Moreover, notably decreased secretion factors related cytokines. Interestingly, also exerts regulatory dysbiosis cumulative plenteous beneficial probiotics like Lactobacillus Bacteroides, while inhibiting overgrowth opportunistic pathogens such as Helicobacter. cell balance, well modulation microbiota HED, provides further experimental evidence for feasibility its treatment UC.

Язык: Английский

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Comprehensive Mechanistic Investigation of Sanren Decoction in Ulcerative Colitis: Enhancement of the Intestinal Barrier, Modulation of Macrophage Polarization, and Regulation of Gut Microbiota

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Sanren Decoction (SRD) has emerged as a promising therapeutic agent for ulcerative colitis (UC) due to its multifaceted mechanisms of action. This study employed an integrative methodology, including network pharmacology, molecular docking, and in vivo experimentation, elucidate the underlying pharmacological SRD UC management. The findings identified 87 genes targeted by that are associated with UC, highlighting PTGS2 (Prostaglandin-Endoperoxide Synthase 2) crucial target involved inflammatory processes. Molecular docking analysis confirmed significant interactions between active compounds PTGS2, suggesting potential anti-inflammatory pathway. In experiments utilizing DSS-induced mouse model demonstrated effectively ameliorates clinical symptoms histopathological damage, enhances intestinal barrier integrity, modulates macrophage polarization from pro-inflammatory M1 state M2 phenotype. Furthermore, was found alter gut microbiota composition increasing abundance beneficial bacteria influencing metabolic pathways. These establish strong scientific foundation comprehensive approach offering prospects integration into practice.

Язык: Английский

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