Neuroscience, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)
Опубликована: Июль 22, 2024
Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles both normal physiology the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis factors, chemokines, growth factors like TGF-β, VEGF, EGF, can promote or inhibit growth, influence microenvironment, impact efficacy cancer treatments. Recent advances targeting these pathways have shown promising therapeutic potential, offering new strategies to modulate system, progression, overcome resistance conventional therapies. In this review, we summarized current understanding implications cytokine chemokine signaling By exploring molecules biology response, highlighted development novel agents aimed at modulating combat The review elaborated on nature cytokines promoters suppressors tumorigenesis, depending context, discussed challenges opportunities presents for intervention. We also examined latest advancements targeted therapies, monoclonal antibodies, bispecific receptor inhibitors, fusion proteins, engineered variants, their metastasis, microenvironment. Additionally, evaluated potential combining therapies with other treatment modalities improve patient outcomes. Besides, focused ongoing research clinical trials that pivotal advancing our application cytokine- chemokine-targeted patients.
Язык: Английский
Процитировано
60
Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116783 - 116783
Опубликована: Май 25, 2024
During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.
Язык: Английский
Процитировано
10
International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140382 - 140382
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
1
Cancers, Год журнала: 2023, Номер 16(1), С. 194 - 194
Опубликована: Дек. 30, 2023
The peritoneum is the most common metastatic site of advanced gastric cancer and associated with extremely poor prognosis. Endothelial-specific molecule 1 (ESM1) was found to be significantly peritoneal metastasis (GCPM); however, biological functions molecular mechanisms ESM1 in regulating GCPM remain unclear. Herein, we demonstrated that expression upregulated tissues positively correlated platelet endothelial cell adhesion molecule-1 (CD31) levels. Moreover, clinical validation, vitro vivo experiments, confirmed promoted angiogenesis, eventually promoting metastasis. Mechanistically, tumor angiogenesis by binding c-Met on vascular membrane. In addition, our results VEGFA, HIF1α, MMP9 induced activating MAPK/ERK pathway. conclusion, findings identified role GCPM, thus providing insights into diagnosis treatment cancer.
Язык: Английский
Процитировано
18
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(6), С. 189020 - 189020
Опубликована: Ноя. 1, 2023
Язык: Английский
Процитировано
11
Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)
Опубликована: Апрель 2, 2024
Abstract Lung cancer is a deeply malignant tumor with high incidence and mortality. Despite the rapid development of diagnosis treatment technology, abundant patients lung are still inevitably faced recurrence metastasis, contributing to death. Lymphatic metastasis first step distant an important prognostic indicator non-small cell cancer. Tumor-induced lymphangiogenesis involved in construction microenvironment, except promoting proliferation cells, it also plays crucial role individual response treatment, especially immunotherapy. Thus, this article reviews current research status lymphatic cancer, order provide some insights for basic clinical translational application field.
Язык: Английский
Процитировано
4
Current Treatment Options in Oncology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 22, 2025
Язык: Английский
Процитировано
0
Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101254 - 101254
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
npj Precision Oncology, Год журнала: 2025, Номер 9(1)
Опубликована: Март 12, 2025
Abstract Bladder cancer (BCa) is a prevalent malignancy with poor prognosis. SLC7A7 has been linked to BCa progression and angiogenesis, but its specific role remains unclear. We established SLC7A7-knockdown cell line investigate effects on angiogenesis. In vivo experiments assessed tumor vascularization, while in vitro studies explored exosome involvement. MiRNA sequencing identified miR-152-3p as key regulator. Further investigation using dual-luciferase reporter assays, qRT-PCR, Western blot revealed that inhibits the expression of FGFR3 by binding 3’ UTR. Meanwhile, functional including angiogenesis Transwell wound healing were performed evaluate confirmed significant progression, specifically promoting through involvement exosomes regulatory axis miR-152-3p/ FGFR3. Targeting might be promising strategy reverse control for an improved
Язык: Английский
Процитировано
0
Clinical and Translational Medicine, Год журнала: 2025, Номер 15(4)
Опубликована: Апрель 1, 2025
Abstract Angiogenesis, as a core marker of cancer survival and growth, is integral to the processes tumour invasion metastasis. In recent years, targeted angiogenesis treatment strategies have gradually become an important direction in treatment. Single‐cell sequencing technology can provide new insights into by providing deeper understanding heterogeneity endothelial cells exploring interactions between surrounding microenvironment. Here, we systematically review research progress cell pathophysiology its endothelial‒mesenchymal transition illustrate from single‐cell perspective. Finally, examine contributions different types within microenvironment relation angiogenesis, well latest therapy, hoping useful clinical application antiangiogenic Furthermore, summary present development potential inhibitors ongoing trials for combination therapies provided. Key points Angiogenesis plays key role progression, metastasis, so targeting are becoming therapy. Interactions stromal immune significant angiogenesis. The immunotherapy nanotechnology therapy provides vital strategy prolonging patients.
Язык: Английский
Процитировано
0