Research progress on platelets in glioma DOI Creative Commons

Mingrong Zuo,

Tengfei Li, Zhihao Wang

и другие.

Chinese Medical Journal, Год журнала: 2024, Номер unknown

Опубликована: Сен. 10, 2024

Abstract Gliomas are the most common primary neuroepithelial tumors of central nervous system in adults, which glioblastoma is deadliest subtype. Apart from intrinsically indestructible characteristics glioma (stem) cells, accumulating evidence suggests that tumor microenvironment also plays a vital role refractoriness glioblastoma. The functions platelets to stop bleeding and regulate thrombosis under physiological conditions. Furthermore, active elements participate variety processes development, including growth, invasion, chemoresistance. Glioma cells recruit activate resting become tumor-educated (TEPs), turn can promote proliferation, stemness, chemoresistance cells. TEPs be used obtain genetic information about gliomas, helpful for early diagnosis monitoring therapeutic effects. Platelet membranes intriguing biomimetic materials developing efficacious drug carriers enhance antiglioma activity. Herein, we review recent research referring contribution malignant gliomas focusing on molecular mechanisms mediating interaction between as well present challenges opportunities targeting therapy.

Язык: Английский

Targeting cytokine and chemokine signaling pathways for cancer therapy DOI Creative Commons
Ming Yi, Tianye Li,

Mengke Niu

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Июль 22, 2024

Abstract Cytokines are critical in regulating immune responses and cellular behavior, playing dual roles both normal physiology the pathology of diseases such as cancer. These molecules, including interleukins, interferons, tumor necrosis factors, chemokines, growth factors like TGF-β, VEGF, EGF, can promote or inhibit growth, influence microenvironment, impact efficacy cancer treatments. Recent advances targeting these pathways have shown promising therapeutic potential, offering new strategies to modulate system, progression, overcome resistance conventional therapies. In this review, we summarized current understanding implications cytokine chemokine signaling By exploring molecules biology response, highlighted development novel agents aimed at modulating combat The review elaborated on nature cytokines promoters suppressors tumorigenesis, depending context, discussed challenges opportunities presents for intervention. We also examined latest advancements targeted therapies, monoclonal antibodies, bispecific receptor inhibitors, fusion proteins, engineered variants, their metastasis, microenvironment. Additionally, evaluated potential combining therapies with other treatment modalities improve patient outcomes. Besides, focused ongoing research clinical trials that pivotal advancing our application cytokine- chemokine-targeted patients.

Язык: Английский

Процитировано

72

Survival strategies: How tumor hypoxia microenvironment orchestrates angiogenesis DOI Open Access

Mengchao YANG,

Yufeng Mu,

Xiaoyun Yu

и другие.

Biomedicine & Pharmacotherapy, Год журнала: 2024, Номер 176, С. 116783 - 116783

Опубликована: Май 25, 2024

During tumor development, the itself must continuously generate new blood vessels to meet their growth needs while also allowing for invasion and metastasis. One of most common features tumors is hypoxia, which drives process angiogenesis by regulating microenvironment, thus adversely affecting prognosis patients. In addition, overcome unsuitable environments growth, such as nutrient deficiency, hyperacidity, immunosuppression, microenvironment (TME) coordinates in several ways restore supply oxygen nutrients remove metabolic wastes. A growing body research suggests that hypoxia interact through a complex interplay crosstalk, inextricably linked TME. Here, we review TME's positive contribution from an angiogenesis-centric perspective considering objective impact hypoxic phenotypes status limitations current angiogenic therapies.

Язык: Английский

Процитировано

11

Candidate Biomarker of Response to Immunotherapy In Small Cell Lung Cancer DOI

Yili Shen,

Zhicong Liu, Yi Chen

и другие.

Current Treatment Options in Oncology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 22, 2025

Язык: Английский

Процитировано

1

A bioactive polysaccharide derived from Rosa laevigata fruits: Structural properties, antitumor efficacy, and potential mechanisms DOI

Xiaoyang Guo,

Fan Nie,

Haojing Jiang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 140382 - 140382

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

1

Naringenin: a potential therapeutic agent for modulating angiogenesis and immune response in hepatocellular carcinoma DOI Creative Commons

Wenmei Wu,

Xiangyu Qiu,

Xiaofan Ye

и другие.

Journal of Pharmaceutical Analysis, Год журнала: 2025, Номер unknown, С. 101254 - 101254

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

1

Understanding Neovascularization in Glioblastoma: Insights from the Current Literature DOI Open Access
Mariagiovanna Ballato, Emanuela Germanà, Gabriele Ricciardi

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(6), С. 2763 - 2763

Опубликована: Март 19, 2025

Glioblastomas (GBMs), among the most aggressive and resilient brain tumors, characteristically exhibit high angiogenic potential, leading to formation of a dense yet aberrant vasculature, both morphologically functionally. With these premises, numerous expectations were initially placed on anti-angiogenic therapies, soon dashed by their limited efficacy in concretely improving patient outcomes. Neovascularization GBM emerged as complex, dynamic, heterogeneous process, hard manage with classical standard care. Growing evidence has revealed existence non-canonical strategies angiogenesis, variously exploited meet its ever-increasing metabolic demand differently involved tumor progression, recurrence, escape from treatments. In this review, we provide an accurate description each neovascularization mode encountered tumors date, highlighting molecular players signaling cascades primarily involved. We also detail key architectural functional aspects characteristic vascular compartment because intricate crosstalk between different networks. Additionally, explore repertoire emerging therapies against that are currently under study, concluding question: faced such challenging scenario, could combined tailored patient’s genetic signatures, represent effective game changer?

Язык: Английский

Процитировано

1

ESM1 Interacts with c-Met to Promote Gastric Cancer Peritoneal Metastasis by Inducing Angiogenesis DOI Open Access

Jiaoyang Yang,

Gege Shu,

Tao Chen

и другие.

Cancers, Год журнала: 2023, Номер 16(1), С. 194 - 194

Опубликована: Дек. 30, 2023

The peritoneum is the most common metastatic site of advanced gastric cancer and associated with extremely poor prognosis. Endothelial-specific molecule 1 (ESM1) was found to be significantly peritoneal metastasis (GCPM); however, biological functions molecular mechanisms ESM1 in regulating GCPM remain unclear. Herein, we demonstrated that expression upregulated tissues positively correlated platelet endothelial cell adhesion molecule-1 (CD31) levels. Moreover, clinical validation, vitro vivo experiments, confirmed promoted angiogenesis, eventually promoting metastasis. Mechanistically, tumor angiogenesis by binding c-Met on vascular membrane. In addition, our results VEGFA, HIF1α, MMP9 induced activating MAPK/ERK pathway. conclusion, findings identified role GCPM, thus providing insights into diagnosis treatment cancer.

Язык: Английский

Процитировано

21

Updated aspects of alpha‐Solanine as a potential anticancer agent: Mechanistic insights and future directions DOI Creative Commons
Sudeshna Nandi,

Rimpa Sikder,

Anish Nag

и другие.

Food Science & Nutrition, Год журнала: 2024, Номер 12(10), С. 7088 - 7107

Опубликована: Авг. 29, 2024

Abstract Cancer remains a critical global health challenge, with limited progress in reducing mortality despite advancements diagnosis and treatment. The growing resistance of tumors to existing chemotherapy exacerbates this burden. In response, the search for new anticancer compounds from plants has intensified, given their historical success yielding effective treatments. This review focuses on α‐solanine, glycoalkaloid primarily derived potato tubers nightshade family plants, recognized its diverse biological activities, including anti‐allergic, antipyretic, anti‐inflammatory, anti‐diabetic, antibiotic properties. Recently, α‐solanine gained attention as potential agent. Utilizing resources like PubMed/MedLine, ScienceDirect, Web Science, Scopus, American Chemical Society, Google Scholar, Springer Link, Wiley, various commercial websites, consolidates two decades research α‐solanine's effects mechanisms against nine different cancers, highlighting role modulating signaling pathways. It also discusses lead compound cancer therapy. abundant availability peel, often discarded waste or sold cheaply, is suggested sustainable source large‐scale extraction. study concludes that holds promise standalone adjunctive However, further necessary optimize mitigate toxicity through strategies.

Язык: Английский

Процитировано

6

Changing landscape of anti-angiogenic therapy: Novel approaches and clinical perspectives DOI Open Access
Rajesh N. Gacche

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2023, Номер 1878(6), С. 189020 - 189020

Опубликована: Ноя. 1, 2023

Язык: Английский

Процитировано

12

Self‐Assembled Acid‐Responsive Nanosystem for Synergistic Anti‐Angiogenic/Photothermal/Ferroptosis Therapy against Esophageal Cancer DOI
Xiaokun Li, Jiamei Li,

Siqin He

и другие.

Advanced Healthcare Materials, Год журнала: 2023, Номер 13(6)

Опубликована: Ноя. 22, 2023

Abstract Esophageal cancer (EC) treatment via anti‐angiogenic therapy faces challenges due to non‐cytotoxicity and non‐specific biodistribution of the agents. Hence, quest for a synergistic modality targeted delivery approach effectively address EC has become imperative. In this study, an acid‐responsive release nanosystem (Bev‐IR820@Fe III TA) that involves conjugation bevacizumab, monoclonal antibody, with TA Fe 3+ form metal‐phenolic network, followed by loading near‐infrared photothermal agent (IR820) achieve combinational therapy, is designed. The construction Bev‐IR820@Fe can be realized through facile self‐assembly process. exhibits tumor‐targeting capabilities therapeutic effects, encompassing (PTT), ferroptosis (FT). remarkable proficiency in delivering drugs tissue its pH‐responsive properties. Consequently, bevacizumab exerts effects obstructing tumor angiogenesis, thereby impeding growth. Meanwhile, PTT facilitates localized thermal ablation at site, directly eradicating cells. FT synergistically collaborates PTT, giving rise formation reactive oxygen species (ROS) storm, subsequently culminating demise summary, amalgamated carries substantial promise progression showcases auspicious prospects future treatment.

Язык: Английский

Процитировано

10