Chinese Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 10, 2024
Abstract
Gliomas
are
the
most
common
primary
neuroepithelial
tumors
of
central
nervous
system
in
adults,
which
glioblastoma
is
deadliest
subtype.
Apart
from
intrinsically
indestructible
characteristics
glioma
(stem)
cells,
accumulating
evidence
suggests
that
tumor
microenvironment
also
plays
a
vital
role
refractoriness
glioblastoma.
The
functions
platelets
to
stop
bleeding
and
regulate
thrombosis
under
physiological
conditions.
Furthermore,
active
elements
participate
variety
processes
development,
including
growth,
invasion,
chemoresistance.
Glioma
cells
recruit
activate
resting
become
tumor-educated
(TEPs),
turn
can
promote
proliferation,
stemness,
chemoresistance
cells.
TEPs
be
used
obtain
genetic
information
about
gliomas,
helpful
for
early
diagnosis
monitoring
therapeutic
effects.
Platelet
membranes
intriguing
biomimetic
materials
developing
efficacious
drug
carriers
enhance
antiglioma
activity.
Herein,
we
review
recent
research
referring
contribution
malignant
gliomas
focusing
on
molecular
mechanisms
mediating
interaction
between
as
well
present
challenges
opportunities
targeting
therapy.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Июль 22, 2024
Abstract
Cytokines
are
critical
in
regulating
immune
responses
and
cellular
behavior,
playing
dual
roles
both
normal
physiology
the
pathology
of
diseases
such
as
cancer.
These
molecules,
including
interleukins,
interferons,
tumor
necrosis
factors,
chemokines,
growth
factors
like
TGF-β,
VEGF,
EGF,
can
promote
or
inhibit
growth,
influence
microenvironment,
impact
efficacy
cancer
treatments.
Recent
advances
targeting
these
pathways
have
shown
promising
therapeutic
potential,
offering
new
strategies
to
modulate
system,
progression,
overcome
resistance
conventional
therapies.
In
this
review,
we
summarized
current
understanding
implications
cytokine
chemokine
signaling
By
exploring
molecules
biology
response,
highlighted
development
novel
agents
aimed
at
modulating
combat
The
review
elaborated
on
nature
cytokines
promoters
suppressors
tumorigenesis,
depending
context,
discussed
challenges
opportunities
presents
for
intervention.
We
also
examined
latest
advancements
targeted
therapies,
monoclonal
antibodies,
bispecific
receptor
inhibitors,
fusion
proteins,
engineered
variants,
their
metastasis,
microenvironment.
Additionally,
evaluated
potential
combining
therapies
with
other
treatment
modalities
improve
patient
outcomes.
Besides,
focused
ongoing
research
clinical
trials
that
pivotal
advancing
our
application
cytokine-
chemokine-targeted
patients.
Biomedicine & Pharmacotherapy,
Год журнала:
2024,
Номер
176, С. 116783 - 116783
Опубликована: Май 25, 2024
During
tumor
development,
the
itself
must
continuously
generate
new
blood
vessels
to
meet
their
growth
needs
while
also
allowing
for
invasion
and
metastasis.
One
of
most
common
features
tumors
is
hypoxia,
which
drives
process
angiogenesis
by
regulating
microenvironment,
thus
adversely
affecting
prognosis
patients.
In
addition,
overcome
unsuitable
environments
growth,
such
as
nutrient
deficiency,
hyperacidity,
immunosuppression,
microenvironment
(TME)
coordinates
in
several
ways
restore
supply
oxygen
nutrients
remove
metabolic
wastes.
A
growing
body
research
suggests
that
hypoxia
interact
through
a
complex
interplay
crosstalk,
inextricably
linked
TME.
Here,
we
review
TME's
positive
contribution
from
an
angiogenesis-centric
perspective
considering
objective
impact
hypoxic
phenotypes
status
limitations
current
angiogenic
therapies.
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(6), С. 2763 - 2763
Опубликована: Март 19, 2025
Glioblastomas
(GBMs),
among
the
most
aggressive
and
resilient
brain
tumors,
characteristically
exhibit
high
angiogenic
potential,
leading
to
formation
of
a
dense
yet
aberrant
vasculature,
both
morphologically
functionally.
With
these
premises,
numerous
expectations
were
initially
placed
on
anti-angiogenic
therapies,
soon
dashed
by
their
limited
efficacy
in
concretely
improving
patient
outcomes.
Neovascularization
GBM
emerged
as
complex,
dynamic,
heterogeneous
process,
hard
manage
with
classical
standard
care.
Growing
evidence
has
revealed
existence
non-canonical
strategies
angiogenesis,
variously
exploited
meet
its
ever-increasing
metabolic
demand
differently
involved
tumor
progression,
recurrence,
escape
from
treatments.
In
this
review,
we
provide
an
accurate
description
each
neovascularization
mode
encountered
tumors
date,
highlighting
molecular
players
signaling
cascades
primarily
involved.
We
also
detail
key
architectural
functional
aspects
characteristic
vascular
compartment
because
intricate
crosstalk
between
different
networks.
Additionally,
explore
repertoire
emerging
therapies
against
that
are
currently
under
study,
concluding
question:
faced
such
challenging
scenario,
could
combined
tailored
patient’s
genetic
signatures,
represent
effective
game
changer?
Cancers,
Год журнала:
2023,
Номер
16(1), С. 194 - 194
Опубликована: Дек. 30, 2023
The
peritoneum
is
the
most
common
metastatic
site
of
advanced
gastric
cancer
and
associated
with
extremely
poor
prognosis.
Endothelial-specific
molecule
1
(ESM1)
was
found
to
be
significantly
peritoneal
metastasis
(GCPM);
however,
biological
functions
molecular
mechanisms
ESM1
in
regulating
GCPM
remain
unclear.
Herein,
we
demonstrated
that
expression
upregulated
tissues
positively
correlated
platelet
endothelial
cell
adhesion
molecule-1
(CD31)
levels.
Moreover,
clinical
validation,
vitro
vivo
experiments,
confirmed
promoted
angiogenesis,
eventually
promoting
metastasis.
Mechanistically,
tumor
angiogenesis
by
binding
c-Met
on
vascular
membrane.
In
addition,
our
results
VEGFA,
HIF1α,
MMP9
induced
activating
MAPK/ERK
pathway.
conclusion,
findings
identified
role
GCPM,
thus
providing
insights
into
diagnosis
treatment
cancer.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(10), С. 7088 - 7107
Опубликована: Авг. 29, 2024
Abstract
Cancer
remains
a
critical
global
health
challenge,
with
limited
progress
in
reducing
mortality
despite
advancements
diagnosis
and
treatment.
The
growing
resistance
of
tumors
to
existing
chemotherapy
exacerbates
this
burden.
In
response,
the
search
for
new
anticancer
compounds
from
plants
has
intensified,
given
their
historical
success
yielding
effective
treatments.
This
review
focuses
on
α‐solanine,
glycoalkaloid
primarily
derived
potato
tubers
nightshade
family
plants,
recognized
its
diverse
biological
activities,
including
anti‐allergic,
antipyretic,
anti‐inflammatory,
anti‐diabetic,
antibiotic
properties.
Recently,
α‐solanine
gained
attention
as
potential
agent.
Utilizing
resources
like
PubMed/MedLine,
ScienceDirect,
Web
Science,
Scopus,
American
Chemical
Society,
Google
Scholar,
Springer
Link,
Wiley,
various
commercial
websites,
consolidates
two
decades
research
α‐solanine's
effects
mechanisms
against
nine
different
cancers,
highlighting
role
modulating
signaling
pathways.
It
also
discusses
lead
compound
cancer
therapy.
abundant
availability
peel,
often
discarded
waste
or
sold
cheaply,
is
suggested
sustainable
source
large‐scale
extraction.
study
concludes
that
holds
promise
standalone
adjunctive
However,
further
necessary
optimize
mitigate
toxicity
through
strategies.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(6)
Опубликована: Ноя. 22, 2023
Abstract
Esophageal
cancer
(EC)
treatment
via
anti‐angiogenic
therapy
faces
challenges
due
to
non‐cytotoxicity
and
non‐specific
biodistribution
of
the
agents.
Hence,
quest
for
a
synergistic
modality
targeted
delivery
approach
effectively
address
EC
has
become
imperative.
In
this
study,
an
acid‐responsive
release
nanosystem
(Bev‐IR820@Fe
III
TA)
that
involves
conjugation
bevacizumab,
monoclonal
antibody,
with
TA
Fe
3+
form
metal‐phenolic
network,
followed
by
loading
near‐infrared
photothermal
agent
(IR820)
achieve
combinational
therapy,
is
designed.
The
construction
Bev‐IR820@Fe
can
be
realized
through
facile
self‐assembly
process.
exhibits
tumor‐targeting
capabilities
therapeutic
effects,
encompassing
(PTT),
ferroptosis
(FT).
remarkable
proficiency
in
delivering
drugs
tissue
its
pH‐responsive
properties.
Consequently,
bevacizumab
exerts
effects
obstructing
tumor
angiogenesis,
thereby
impeding
growth.
Meanwhile,
PTT
facilitates
localized
thermal
ablation
at
site,
directly
eradicating
cells.
FT
synergistically
collaborates
PTT,
giving
rise
formation
reactive
oxygen
species
(ROS)
storm,
subsequently
culminating
demise
summary,
amalgamated
carries
substantial
promise
progression
showcases
auspicious
prospects
future
treatment.
