Metabolites,
Год журнала:
2023,
Номер
13(11), С. 1143 - 1143
Опубликована: Ноя. 11, 2023
Chikungunya
virus
(CHIKV)
is
transmitted
to
humans
by
mosquitoes
of
the
genus
Aedes,
causing
chikungunya
fever
disease,
associated
with
inflammation
and
severe
articular
incapacitating
pain.
There
has
been
a
worldwide
reemergence
number
cases
increased
271,006
in
2022
Americas
alone.
The
replication
CHIKV
takes
place
several
cell
types,
including
phagocytic
cells.
Monocytes
macrophages
are
susceptible
infection
CHIKV;
at
same
time,
they
provide
protection
as
components
innate
immune
system.
However,
host–pathogen
interactions,
might
have
ability
alter
function
cells,
partly
rewiring
tricarboxylic
acid
cycle.
Some
viral
evasion
mechanisms
depend
on
metabolic
reprogramming
metabolism
intertwined
circadian
rhythmicity;
thus,
immunovirometabolism
axis
may
influence
pathogenicity.
Therefore,
analyzing
interplay
between
infection,
rhythmicity,
cellular
human
could
shed
some
light
new
field
eventually
contribute
development
novel
drugs
therapeutic
approaches
based
rhythmicity
reprogramming.
Viruses,
Год журнала:
2024,
Номер
16(6), С. 913 - 913
Опубликована: Июнь 4, 2024
African
swine
fever
(ASF)
is
a
contagious
viral
disease
affecting
pigs
and
wild
boars.
It
typically
presents
as
hemorrhagic
but
can
also
manifest
in
various
forms,
ranging
from
acute
to
asymptomatic.
ASF
has
spread
extensively
globally,
significantly
impacting
the
industry.
The
complex
highly
variable
character
of
ASFV
genome
makes
vaccine
development
surveillance
extremely
difficult.
overall
trend
evolution
towards
decreased
virulence
increased
transmissibility.
Factors
such
gene
mutation,
recombination,
strain-specificity
virulence-associated
genes
facilitate
variations.
This
review
deeply
discusses
influence
these
factors
on
immune
evasion,
pathogenicity,
ensuing
complexities
encountered
development,
detection,
surveillance.
ultimate
goal
this
thoroughly
explore
genetic
patterns
variation
mechanisms
ASFV,
providing
theoretical
foundation
for
advancement
diagnostic
technologies.
Veterinary Research,
Год журнала:
2025,
Номер
56(1)
Опубликована: Апрель 1, 2025
Abstract
Foot-and-mouth
disease
(FMD)
severely
restricts
the
healthy
development
of
global
animal
husbandry,
and
unclear
pathogenic
mechanism
FMD
virus
(FMDV)
leads
to
difficulty
in
preventing
purifying
FMD.
Glycolytic
remodelling
is
considered
one
hallmarks
viral
infection,
providing
energy
precursors
for
assembly
replication.
In
this
work,
interaction
between
FMDV
glycolysis
were
explored
from
perspective
immune
metabolism.
We
found
that
infection
increased
extracellular
acidification
rate,
lactic
acid
accumulation,
HK2
level.
addition,
during
enhances
glycolytic
activity
mediates
autophagic
degradation
IRF3/7
antagonize
innate
response,
thereby
promoting
Our
findings
provide
evidence
closely
correlated
with
host
metabolism,
increasing
understanding
facilitate
new
ideas
further
elucidating
FMDV.
Molecular Biology Reports,
Год журнала:
2024,
Номер
51(1)
Опубликована: Март 5, 2024
Abstract
Purpose
Vault
(vt)
RNAs
are
noncoding
(nc)
transcribed
by
RNA
polymerase
III
(RNA
Pol
III)
with
5ʹ-triphosphate
(5ʹ-PPP)
termini
that
play
significant
roles
and
recognized
innate
immune
sensors,
including
retinoic
acid-inducible
protein
1
(RIG-I).
In
addition,
vtRNAs
adopt
secondary
structures
can
be
targets
of
interferon-inducible
kinase
R
(PKR)
the
oligoadenylate
synthetase
(OAS)/RNase
L
system,
both
which
important
for
activating
antiviral
defenses.
However,
changes
in
expression
have
been
associated
pathological
processes
activate
proinflammatory
pathways,
influence
cellular
events
such
as
differentiation,
aging,
autophagy,
apoptosis,
drug
resistance
cancer
cells.
Results
this
review,
we
summarized
biology
focused
on
their
interactions
system.
These
findings
provide
insights
into
diverse
correlation
various
to
improve
our
understanding
biological
functions.
Biology,
Год журнала:
2025,
Номер
14(2), С. 121 - 121
Опубликована: Янв. 24, 2025
Haliotid
herpesvirus
1
(HAHV-1)
causes
significant
damage
to
the
abalone
aquaculture
industry.
Knowledge
of
HAHV-1
invasion
and
host
defense
mechanisms
is
limited
due
lack
stable
molluscan
cell
lines.
The
present
study
established
an
in
vitro
infection
model
using
primary
suspension
cultures
hemocytes
from
Haliotis
diversicolor
supertexta
discus
hannai.
cytopathic
effects
on
adherent-cultured
both
species
were
also
investigated.
DNA
loads
firstly
monitored
by
means
quantitative
PCR
during
development
viral
infection,
subsequently
mechanism
interaction
between
was
explored
a
transcriptome
analysis.
H.
exhibited
high
degree
susceptibility
HAHV-1,
with
reaching
peak
4.0
×
10⁷
copies/ng
DNA.
In
contrast,
no
replication
observed
hannai
hemocytes.
Transcriptome
analysis
revealed
that
evades
immune
response
early
stages
hijacks
host’s
energy
redox
metabolism
promote
its
at
late
stages.
Consequently,
this
provides
valuable
reference
point
for
investigation
virus−host
vitro.
Veterinary Sciences,
Год журнала:
2025,
Номер
12(2), С. 138 - 138
Опубликована: Фев. 7, 2025
Viruses
can
manipulate
the
host
metabolism
to
achieve
optimal
replication
conditions,
and
central
carbon
(CCM)
pathways
are
often
crucial
in
determining
viral
infections.
Feline
calicivirus
(FCV),
a
diminutive
RNA
agent,
induces
upper
respiratory
tract
infections
feline
hosts,
with
highly
pathogenic
strains
capable
of
precipitating
systemic
subsequent
cell
necrosis,
thereby
presenting
formidable
challenge
survival
protection.
However,
relationship
between
FCV
remains
unclear,
precise
mechanisms
yet
be
elucidated.
Upon
infection
Crandell-Rees
Kidney
(CRFK)
cells,
an
enhanced
cellular
uptake
glucose
glutamine
was
observed.
Metabolomics
analyses
disclosed
pronounced
alterations
infected
cells.
found
augment
glycolytic
activity
while
sustaining
tricarboxylic
acid
(TCA)
cycle
flux,
ATP
levels
remaining
invariant.
Concurrently,
both
flux
pentose
phosphate
pathway
(PPP)
were
noted
intensified.
The
application
various
inhibitory
agents
targeting
glycolysis,
metabolism,
PPP
resulted
significant
suppression
proliferation.
Experiments
involving
deprivation
demonstrated
that
absence
either
nutrient
markedly
curtailed
replication.
Collectively,
these
findings
suggest
critical
interplay
stimulates
CRFK
cells
uptake,
supplying
necessary
metabolic
substrates
energy
for
During
infection,
emerges
as
primary
substrate,
ensuring
production
homeostasis,
is
predominantly
channeled
into
facilitate
nucleotide
synthesis.
