Distinct CD8+ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2+ Patients

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 14, 2025

Abstract Although emerging data have revealed the critical role of memory CD8 + T cells in preventing and controlling SARS-CoV-2 infection, virus-specific T-cell responses against its innate-like subsets unvaccinated COVID-19 patients with various disease manifestations an HLA-restricted fashion remain to be understood. Here, we show strong association protective cellular immunity mild unique cell types virus HLA-A2 restricted manner. ELISpot assays reveal that SARS-CoV-2-specific are significantly higher than severe patients, whereas neutralizing antibody correlate severity. Single-cell analyses HLA-A2-restricted cells, which recognize highly conserved immunodominant epitopes, demonstrate divergent profiles versus disease. including cytotoxic KLRB1 CD8αα signatures, IFNG hi ID3 IL7R proliferative stem cell-like preferentially observed COVID-19, distinct terminally-differentiated predominantly detected COVID-19: activated FASL early-terminated or dysfunctional IL4R GATA3 subset. In conclusion, our findings suggest contrasting may dictate Figure Graphical abstract. epitope-specific subtypes associated patients. Potent gene signature (upper) (lower).

Язык: Английский

HCV immunodominant peptide mapping reveals unique HLA-A*02-restricted signatures: insights for CD8+ T-cell-based vaccines and immunotherapies

Immunogenetics, Год журнала: 2025, Номер 77(1)

Опубликована: Янв. 31, 2025

Язык: Английский