Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents DOI Creative Commons
Oliver Sampson, Cecilia Jay,

Emily Adland

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 28, 2024

mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted need to better understand interaction of adjuvants and early innate immune response. Type I interferon (IFN-I) is an integral part this response that primes several components adaptive Women are widely reported respond than men tri- quadrivalent influenza vaccines. Plasmacytoid dendritic cells (pDCs) primary cell type responsible for IFN-I production, female pDCs produce more male since upstream pattern recognition receptor Toll-like 7 (TLR7) encoded by X chromosome biallelically expressed up 30% cells. Additionally, TLR7 promoter contains putative androgen elements, androgens been suppress pDC in vitro . Unexpectedly, therefore, we recently observed adolescents mount stronger antibody responses Pfizer BNT162b2 after controlling natural infection. We here examined behaviour same cohort determine impact on anti-spike anti-receptor-binding domain IgG titres BNT162b2. Through flow cytometry least absolute shrinkage selection operator (LASSO) modelling, determined serum-free testosterone was associated with reduced IFN-I, but contrary well-described immunosuppressive role androgens, most bioactive dihydrotestosterone increased Also unexpectedly, co-vaccination live attenuated boosted magnitude Together, these data support a model where systemic increases vaccine-mediated responses, yet vaccines intracellular stages, modulation local may alter antigen longevity consequently improve vaccine-driven immunity.

Язык: Английский

Non-cross-reactive epitopes dominate the humoral immune response to COVID-19 vaccination – kinetics of plasma antibodies, plasmablasts and memory B cells DOI Creative Commons
Kilian A. Wietschel,

Kevin Fechtner,

Elmer Antileo

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Май 14, 2024

COVID-19 vaccines are highly effective in inducing protective immunity. While the serum antibody response to vaccination has been studied depth, our knowledge of underlying plasmablast and memory B cell (Bmem) responses is still incomplete. Here, we determined a naïve population contrasted it with single influenza primed cohort. In addition, analyzed against four endemic human coronaviruses (HCoVs).

Язык: Английский

Процитировано

4
Lifestyle and Biochemical Parameters That May Hamper Immune Responses in Pediatric Patients After Immunization with the BNT162b2 mRNA COVID-19 Vaccine DOI Creative Commons
Anthie Damianaki, Antonios Marmarinos, Margaritis Avgeris

и другие.

Diseases, Год журнала: 2025, Номер 13(3), С. 78 - 78

Опубликована: Март 10, 2025

Background: The aim of this study was to evaluate whether increased body mass index (BMI) and biochemical lifestyle parameters linked obesity smoke exposure disrupt immune responses children adolescents following vaccination with the mRNA BNT162b2 vaccine. Methods: A prospective, single-center, cohort conducted. Participants were assigned receive two doses Anti-SARS-CoV-2 IgG neutralizing antibodies (AB) measured before (T0) 14 days after second dose (T1). BMI evaluated at T0. questionnaire on characteristics filled in. Results: optical density (OD) ratio T1 lower in overweight–obese group regardless COVID-19 disease positive history [p = 0.028 for seronegative group, p 0.032 seropositive group]. Neutralizing AB participants 0.008]. HDL, fasting glucose/insulin (FGIR), C-reactive protein (CRP), HBA1c, uric acid, significantly correlated 0.006, < 0.001, 0.009, respectively]. main that inversely titers acid 0.018, 0.002], FGIR 0.008] HBA1C 0.027, 0.038], while negatively affected humoral T0 convalescent 0.004, 0.005]. Conclusions: Current data suggests insulin resistance (IR), could adversely affect vaccinated children, highlighting need actions enhance protection particular subgroup.

Язык: Английский

Процитировано

0
Immunological drivers of zoonotic virus emergence, evolution, and endemicity DOI
Jyothi N. Purushotham, Holly L. Lutz, Edyth Parker

и другие.

Immunity, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Disparities in response to mRNA SARS-CoV-2 vaccines according to sex and age: a systematic review DOI Creative Commons

María Consuelo Bachmann,

Nejla Gültekin,

Zeno Stanga

и другие.

New Microbes and New Infections, Год журнала: 2024, Номер 63, С. 101551 - 101551

Опубликована: Дек. 7, 2024

The rapid development and distribution of mRNA COVID-19 vaccines has been essential in containing the SARS-CoV-2 epidemic around globe. For ongoing future immunization campaigns globally, there is a need to evaluate impact population demographics such as age sex, on vaccine efficacy safety. This systematic review (PROSPERO ID CRD42023328245) conducted according PRISMA guidelines evaluates sex safety vaccinations administrated 15 studies that were chosen strict criteria. ROBIS tool was applied robustness quality included review. After screening, satisfied inclusion results showed typically elicit robust immune responses, younger people have higher antibody levels. Comparing sexes reveals immunological responses induced females, mild moderate adverse effects (such injection site discomfort, exhaustion, headaches) also more frequently reported women. Despite these variations, found be safe use across diverse populations, which supports their extensive public health initiatives. Our suggests tailored vaccination may achieve maximum effectiveness better tolerability depending sex. Currently study are rarely stratified by this deficit clinical trial publications. More research needed elucidate biological mechanisms underlying variations

Язык: Английский

Процитировано

1
Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents DOI Creative Commons
Oliver Sampson, Cecilia Jay,

Emily Adland

и другие.

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Фев. 28, 2024

mRNA vaccine technologies introduced following the SARS-CoV-2 pandemic have highlighted need to better understand interaction of adjuvants and early innate immune response. Type I interferon (IFN-I) is an integral part this response that primes several components adaptive Women are widely reported respond than men tri- quadrivalent influenza vaccines. Plasmacytoid dendritic cells (pDCs) primary cell type responsible for IFN-I production, female pDCs produce more male since upstream pattern recognition receptor Toll-like 7 (TLR7) encoded by X chromosome biallelically expressed up 30% cells. Additionally, TLR7 promoter contains putative androgen elements, androgens been suppress pDC in vitro . Unexpectedly, therefore, we recently observed adolescents mount stronger antibody responses Pfizer BNT162b2 after controlling natural infection. We here examined behaviour same cohort determine impact on anti-spike anti-receptor-binding domain IgG titres BNT162b2. Through flow cytometry least absolute shrinkage selection operator (LASSO) modelling, determined serum-free testosterone was associated with reduced IFN-I, but contrary well-described immunosuppressive role androgens, most bioactive dihydrotestosterone increased Also unexpectedly, co-vaccination live attenuated boosted magnitude Together, these data support a model where systemic increases vaccine-mediated responses, yet vaccines intracellular stages, modulation local may alter antigen longevity consequently improve vaccine-driven immunity.

Язык: Английский

Процитировано

0