Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing DOI Creative Commons

Huda A. M. Al-Shalan,

Dailun Hu,

Penghao Wang

и другие.

Viruses, Год журнала: 2023, Номер 15(11), С. 2198 - 2198

Опубликована: Окт. 31, 2023

Influenza A virus (IAV) is known to cause mild severe respiratory illness. Under some conditions, the infection can lead pneumonia (viral or bacterial), acute distress syndrome, and other complications that be fatal, especially in vulnerable populations such as elderly, young children, individuals with underlying health conditions. Despite previous studies, little about host immune response neuroimmune interactions IAV infection. Using RNA sequencing, we performed transcriptomic analysis of murine lung tissue 21 days post (dpi) (H1N1) order find differentially expression genes (DEGs) related inside during recovery. Among 792 DEGs, 434 were up-regulated, whereas 358 down-regulated. The most prominent molecular functions up-regulated repair, a large proportion down-regulated associated neural functions. Although further molecular/functional studies need for these our results facilitate understanding (from innate immunity adaptive immunity) infected lungs at recovery stage These might have potential uses mechanistic/diagnostic biomarkers represent possible targets anti-IAV therapies.

Язык: Английский

Innate and adaptive immune system consequences of post-traumatic stress disorder DOI

Tatlock H. Lauten,

Tamara Natour, Adam J. Case

и другие.

Autonomic Neuroscience, Год журнала: 2024, Номер 252, С. 103159 - 103159

Опубликована: Фев. 23, 2024

Язык: Английский

Процитировано

8
Unraveling the peripheral nervous System's role in tumor: A Double-edged Sword DOI
Yanhao Wang, Yang Xuan,

Cuicui Liu

и другие.

Cancer Letters, Год журнала: 2025, Номер 611, С. 217451 - 217451

Опубликована: Янв. 8, 2025

Язык: Английский

Процитировано

1
Aging brain: exploring the interplay between bone marrow aging, immunosenescence, and neuroinflammation DOI Creative Commons

Ludmila Müller,

Svetlana Di Benedetto

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Апрель 4, 2024

Aging is a complex process characterized by myriad of physiological changes, including alterations in the immune system termed immunosenescence. It exerts profound effects on both bone marrow and central nervous system, with significant implications for immunosenescence neurological contexts. Our mini-review explores relationship between aging its impact immunosenescence, specifically within context diseases. The serves as crucial hub hematopoiesis cell production, yet age, it undergoes alterations, hematopoietic stem function, niche composition, inflammatory signaling. These age-related shifts microenvironment contribute to dysregulation homeostasis impacting neuroinflammatory processes neuronal health. In our review, we aim explore cellular molecular mechanisms that link inflammaging, neuroinflammation, specific focus their relevance pathophysiology disorders. By exploring this interplay, strive provide comprehensive understanding how impacts function contributes progression diseases individuals. Ultimately, knowledge can hold substantial promise development innovative therapeutic interventions aimed at preserving mitigating disorders elderly population.

Язык: Английский

Процитировано

5
The therapeutic potential of glucagon-like peptide-1 receptor analogs for neuroinflammation in the setting of asthma DOI Creative Commons
Courtney Lehman, R. Stokes Peebles

Опубликована: Янв. 16, 2025

Glucagon-like peptide-1 (GLP-1) is a hormone that regulates blood glucose levels and produced by the enteroendocrine glands in large small intestines response to consumption of foods contain carbohydrates, fats, proteins. When GLP-1 secreted, it acts on pancreas increase insulin production secretion, while decreasing pancreatic glucagon secretion order lower serum glucose. However, also metabolism through gut-brain axis. While primarily gut released into bloodstream, quantities can be synthesized distinct areas neurons located hindbrain. Recent studies have proposed receptor (GLP-1R) agonists (GLP-1RAs) may protect against neuroinflammatory diseases. GLP-1RAs therapeutic target for asthma as animal models show these drugs reduce allergen-induced airway inflammation, GLP-1R expressed lung epithelial endothelial cells. There notable association between resistance onset asthma, particularly among obese people, with this suggesting metabolic dysfunction play role development. evidence there link pathobiology neuroinflammation, its analogs regulate pathways contribute pathogenesis. Interest growing, though research remains limited, how inflammation nervous system might linked. This review will explore signaling could inhibit interdependent both system. first focus known exist then pivot current state neural regulation finally speculate GLP-1RA treatment.

Язык: Английский

Процитировано

0
Peripheral CD4 + T cells mediate the destructive effects of maternal separation on prefrontal myelination and cognitive functions DOI Creative Commons

Rui Xiong,

Yinyin Hu,

M‐W Wang

и другие.

Proceedings of the National Academy of Sciences, Год журнала: 2025, Номер 122(16)

Опубликована: Апрель 16, 2025

Maternal separation (MS), a chronic stress event in early life, impairs myelination the prefrontal cortex (PFC) and leads to PFC cognitive disorders. It remains largely unclear how such deficits are mediated. Here, we show that peripheral CD4 + T cells play an essential role mediating destructive effects of MS on medial cortical (mPFC) functions mice. Offspring mice with experience (MS mice) exhibited increase xanthine levels blood severe deficit mPFC-dependent as working memory, social interaction, anxiety/depression emotion regulation, along decrease oligodendrocyte precursor (OPCs) oligodendrocytes (OLs) mPFC. These phenotypes were rescued upon treatment antibody neutralizing cells. Rag1 −/− immunodeficient receiving transplantation isolated from showed similar observed Immunofluorescence staining revealed rich expression adenosine receptor A1 (A1) OPCs mPFC, A1-expressing decreased cell transplantation. The present study demonstrates causal link between MS-induced hypomyelination dysfunction, is probably mediated via xanthine–adenosine signaling OPCs.

Язык: Английский

Процитировано

0
Cutaneous‐immuno‐neuro‐endocrine (CINE) system: A complex enterprise transforming skin into a super organ DOI Open Access
Malvika Shastri, Maryada Sharma, Keshav Sharma

и другие.

Experimental Dermatology, Год журнала: 2024, Номер 33(3)

Опубликована: Март 1, 2024

Abstract Skin is now emerging as a complex realm of three chief systems viz. immune system, nervous and endocrine system. The cells involved in their intricate crosstalk, namely native skin cells, intra‐cutaneous cutaneous sensory neurons have diverse origin distinct functions. However, recent studies explored role beyond pre‐defined functional boundaries, such that the shun traditional functions adopt unconventional roles. For example, apart from providing for basic structural framework skin, also perform special participate extensive neuro‐endocrine circuitry, which were traditionally designated resident respectively. At cellular level, this unique collaboration brought out by molecules called neuromediators including neurotransmitters, neuropeptides, neurotrophins, neurohormones cytokines/chemokines. While crosstalk essential maintaining homeostasis, its disruption seen various diseases. Recent study models led to paradigm shift our understanding pathophysiology many disorders. In review, we described detail interaction with neuromediators, aspect current neuro‐immuno‐endocrine loop one commonest diseases, psoriasis. An accurate knowledge can prove crucial different diseases allow generation targeted therapeutic modalities.

Язык: Английский

Процитировано

2
The impact of COVID-19 on accelerating of immunosenescence and brain aging DOI Creative Commons

Ludmila Müller,

Svetlana Di Benedetto

Frontiers in Cellular Neuroscience, Год журнала: 2024, Номер 18

Опубликована: Дек. 10, 2024

The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has profoundly impacted global health, affecting not only immediate morbidity and mortality rates but also long-term health outcomes across various populations. Although acute effects of on respiratory system have initially been primary focus, it is increasingly evident that virus can significant impacts multiple physiological systems, including nervous immune systems. pandemic highlighted complex interplay between viral infection, aging, brain potentially accelerate neuroimmune aging contribute to persistence long COVID conditions. By inducing chronic inflammation, immunosenescence, neuroinflammation, may exacerbate processes leading increased risks cognitive decline, neurodegenerative diseases, impaired function. Key factors include dysregulation, oxidative stress, disruption cellular processes. These overlapping mechanisms illustrate how induce aging-related processes, an risk diseases other age-related This mini-review examines key features possible COVID-19-induced severity COVID. Understanding these interactions crucial for developing effective interventions. Anti-inflammatory therapies, neuroprotective agents, immunomodulatory treatments, lifestyle interventions all hold potential mitigating virus. addressing challenges, we improve quality life millions affected pandemic.

Язык: Английский

Процитировано

1
Transcriptome Analysis Revealed Potential Immune-Related Genes of Head Kidney in the Yellow Catfish (Pelteobagrus fulvidraco) Challenged with Aeromonas hydrophila DOI Creative Commons
Senhao Jiang, Yuting Lei, Ti Wang

и другие.

Fishes, Год журнала: 2024, Номер 9(3), С. 100 - 100

Опубликована: Март 6, 2024

Yellow catfish (Pelteobagrus fulvidraco) is an important freshwater fish species in aquaculture. However, as intensive farming has rapidly expanded, infectious diseases caused by various bacteria, such Aeromonas hydrophila, have also increased. We conducted a transcriptomic analysis of head kidney from P. fulvidraco stimulated A. hydrophila strain SHOU. A total 43,249 unigenes with average length 1342 bp were obtained following assembly and annotation. By analyzing GO KEGG enrichment, many differentially expressed genes (DEGs) pathways related to immunity identified. Out the 973 DEGs that identified, 553 upregulated 420 downregulated. Moreover, enrichment revealed innate immune system, including TNF signaling pathway, NF-kappa B Toll-like receptor pathway involved defense, activated against response. Real-time quantitative reverse transcription-PCR (qRT-PCR) demonstrated response stimulation compared control. In conclusion, this study provides valuable insights into defense mechanism sheds light on host bacterial infection.

Язык: Английский

Процитировано

0
Transcriptomic Profiling of Influenza A Virus-Infected Mouse Lung at Recovery Stage Using RNA Sequencing DOI Creative Commons

Huda A. M. Al-Shalan,

Dailun Hu,

Penghao Wang

и другие.

Viruses, Год журнала: 2023, Номер 15(11), С. 2198 - 2198

Опубликована: Окт. 31, 2023

Influenza A virus (IAV) is known to cause mild severe respiratory illness. Under some conditions, the infection can lead pneumonia (viral or bacterial), acute distress syndrome, and other complications that be fatal, especially in vulnerable populations such as elderly, young children, individuals with underlying health conditions. Despite previous studies, little about host immune response neuroimmune interactions IAV infection. Using RNA sequencing, we performed transcriptomic analysis of murine lung tissue 21 days post (dpi) (H1N1) order find differentially expression genes (DEGs) related inside during recovery. Among 792 DEGs, 434 were up-regulated, whereas 358 down-regulated. The most prominent molecular functions up-regulated repair, a large proportion down-regulated associated neural functions. Although further molecular/functional studies need for these our results facilitate understanding (from innate immunity adaptive immunity) infected lungs at recovery stage These might have potential uses mechanistic/diagnostic biomarkers represent possible targets anti-IAV therapies.

Язык: Английский

Процитировано

1