This
study
explores
the
role
of
inflammation
and
oxidative
stress,
hallmarks
COVID-19,
in
accelerating
cellular
biological
aging.
We
investigated
early
molecular
markers—DNA
methylation
age
(DNAmAge)
telomere
length
(TL)—in
blood
leukocytes,
nasal
cells
(NC),
induced
sputum
(IS)
one-year
post-infection
pauci-
asymptomatic
healthcare
workers
(HCWs)
infected
during
first
pandemic
wave
(February-May
2020),
compared
to
COPD
patients,
model
for
"aged
lung".
Data
by
questionnaires,
Work
Ability
Index
(WAI),
analyses,
autonomic
cardiac
balance
assessments,
heart
rate
variability
(HRV),
pulmonary
function
tests
were
collected.
Elevated
leukocyte
DNAmAge
significantly
correlated
with
advancing
age,
male
gender,
daytime
work,
an
aged
phenotype
characterized
chronic
diseases,
elevated
LDL
glycemia
levels,
medications
affecting
HRV,
declines
lung
function,
WAI,
lymphocyte
count,
hemoglobin
HRV
(p<0.05).
Increasing
job
positions
involving
intensive
patient
contact,
higher
counts
collectively
contributed
shortened
TL
Notably,
HCWs
exhibited
accelerated
aging
IS
both
leukocytes
(p≤0.05)
NC
(p<0.001),
biologically
older
than
patients
These
findings
suggest
need
monitoring
COVID-19
survivors,
who
represent
majority
general
population.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(12), С. 6389 - 6389
Опубликована: Июнь 9, 2024
Long
COVID
(LC),
also
referred
to
as
Post
COVID-19
Condition,
Post-Acute
Sequelae
of
SARS-CoV-2
Infection
(PASC),
and
other
terms,
represents
a
complex
multisystem
disease
persisting
after
the
acute
phase
COVID-19.
Characterized
by
myriad
symptoms
across
different
organ
systems,
LC
presents
significant
diagnostic
management
challenges.
Central
disorder
is
role
low-grade
inflammation,
non-classical
inflammatory
response
that
contributes
chronicity
diversity
observed.
This
review
explores
pathophysiological
underpinnings
LC,
emphasizing
importance
inflammation
core
component.
By
delineating
pathogenetic
relationships
clinical
manifestations
this
article
highlights
necessity
for
an
integrated
approach
employs
both
personalized
medicine
standardized
protocols
aimed
at
mitigating
long-term
consequences.
The
insights
gained
not
only
enhance
our
understanding
but
inform
development
therapeutic
strategies
could
be
applicable
chronic
conditions
with
similar
features.
Immunologic Research,
Год журнала:
2024,
Номер
72(4), С. 654 - 664
Опубликована: Фев. 20, 2024
Abstract
Moyamoya
disease
(MMD)
is
a
cerebrovascular
disorder
marked
by
progressive
arterial
narrowing,
categorized
into
six
stages
known
as
Suzuki
based
on
angiographic
features.
Growing
evidence
indicates
pivotal
role
of
systemic
immune
and
inflammatory
responses
in
the
initiation
advancement
MMD.
This
study
employs
high-dimensional
mass
cytometry
to
reveal
immunophenotypic
characteristics
peripheral
blood
cells
(PBMCs)
at
various
stages,
offering
insights
progression
PBMC
samples
from
eight
patients
with
early-stage
MMD
(Suzuki
II
III)
later-stage
IV,
V,
VI)
were
analyzed
using
evaluate
frequency
phenotype
cell
subtypes.
We
identified
15
clusters
found
that
immunological
features
are
composed
cluster
variations.
In
this
study,
we
confirmed
that,
compared
MMD,
group
exhibits
an
increase
non-classical
monocytes.
As
stage
level
increases,
proportions
plasmacytoid
DCs
monocyte-derived
decrease.
Furthermore,
T
cells,
monocytes,
DCs,
PMN-MDSCs
show
activation
canonical
NF-κB
signaling
pathway.
summarized
similarities
differences
between
patients.
There
potential
circulating
dysfunction
onset
development
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 26, 2024
Abstract
Background
Post
COVID-19
condition
(PCC)
is
a
complication
of
SARS-COV-2
infection
and
can
lead
to
long-term
disability.
Methods
The
present
study
was
designed
analyse
the
gene
expression
patterns
PCC
through
bulk
RNA
sequencing
whole
blood
explore
potential
molecular
mechanisms
PCC.
Whole
collected
from
80
participants
enrolled
in
prospective
cohort
following
SARS-CoV-2
infected
non-infected
individuals
for
6
months
after
recruitment
used
sequencing.
Identification
differentially
expressed
genes
(DEG),
pathway
enrichment
immune
cell
deconvolution
performed
biological
pathways
involved
Results
We
have
found
13
associated
with
Enriched
were
related
interferon-signalling
anti-viral
processes.
Conclusion
transcriptome
characterized
by
modest
overexpression
interferon-stimulated
genes,
pointing
subtle
ongoing
inflammatory
response.
Brain Behavior & Immunity - Health,
Год журнала:
2025,
Номер
43, С. 100934 - 100934
Опубликована: Янв. 5, 2025
A
considerable
proportion
(21%)
of
patients
with
common
variable
immunodeficiency
(CVID)
suffers
from
depression.
These
subjects
are
characterized
by
reduced
naïve
T
cells
and
a
premature
cell
senescence
similar
to
that
major
depressive
disorder
(MDD).
It
is
known
essential
for
limbic
system
development/function.
Treatment
thymosin
α1
(Tα1)
capable
increase
the
thymus
output
cells.
To
treat
CVID
comorbid
episode
Tα1
thereby
improve
mood.
small
open-label,
proof
concept
trial.
Five
depressed
(Hamilton
Depression
Rating
Scale,
HDRS
>12)
could
be
treated
(8
weeks,
1.6
mg
daily
subcutaneously,
1st
week,
thereafter
twice
weekly).
At
start,
at
8
weeks
after
last
injection,
was
recorded
blood
samples
drawn
measuring
memory
cells,
Th17
Treg
hsCRP,
IL-6
IL-7.
Outcomes
were
compared
those
contrast
group
(42
MDD
patients,
same
severity
but
as
usual
(TAU)).
In
all
5
decreased
during
treatment
(with
average
52%,
TAU
scores
36%
in
patients).
All
showed
an
naïve/memory
CD4+
CD8+
ratios,
4
detectable
levels
reductions
recorded.
did
not
show
such
immune
improvements.
8-week
wash-out,
depression
recurred
2
most
severe
while
continued
others.
Immune
effects
sustained
wash-out.
This
preliminary
study
suggests
hormone
have
antidepressive
related
correcting
effects.
Data
urge
larger
placebo-controlled
trials.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 428 - 428
Опубликована: Фев. 10, 2025
The
Severe
Acute
Respiratory
Syndrome
Coronavirus
2
(SARS-CoV-2)
pandemic
has
imposed
several
medical
and
economic
challenges
since
its
onset
in
2019.
This
is
due
to
ability
target
the
respiratory
system
as
well
other
organs,
resulting
significant
impacts
necessitating
organ
transplants.
Our
goal
compile
information
from
existing
literature
investigate
how
COVID-19
affects
outcomes
following
transplantation.
A
comprehensive
search
was
conducted
studies
reporting
post-COVID-19
complications.
We
included
45
data
related
solid
transplants,
where
either
recipient,
organ,
or
donor
affected
by
SARS-CoV-2.
majority
of
concluded
that
transplantation
infection
could
be
performed
safely
with
similar
non-COVID-19
patients,
regardless
whether
donor,
recipient
COVID-19.
No
deviation
standard
immunosuppression
regimens
surgical
protocols
necessary
either,
further
re-assuring
feasibility
these
transplants
viable
treatment
options.
applies
involving
lungs,
kidneys,
liver,
heart.
However,
there
a
limited
number
some
areas,
which
warrants
need
for
additional
research
order
reach
more
concrete
conclusions
pertaining
COVID-19’s
effect
on
