The interaction between central and peripheral immune systems in methamphetamine use disorder: current status and future directions

Journal of Neuroinflammation, Год журнала: 2025, Номер 22(1)

Опубликована: Фев. 15, 2025

Methamphetamine (METH) use disorder (MUD) is characterized by compulsive drug-seeking behavior and substantial neurotoxicity, posing a considerable burden on individuals society. Traditionally perceived as localized central nervous system disorder, recent preclinical clinical studies have elucidated that MUD multifaceted influenced various biological systems, particularly the immune system. Emerging evidence suggests both peripheral responses play crucial role in initiation persistence of MUD. Conceptualizing it systemic process prompts significant inquiries regarding mechanisms communication between compartments. Also, whether this intercommunication could serve diagnostic biomarkers or therapeutic targets. This review begins offering an overview mechanistic pertaining to neuroimmune systems. Finally, future directions are suggested through integration innovative technologies multidimensional data promote translation basic research into interventions.

Язык: Английский

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Long-COVID-19 autonomic dysfunction: An integrated view in the framework of inflammaging

Mechanisms of Ageing and Development, Год журнала: 2024, Номер 218, С. 111915 - 111915

Опубликована: Фев. 13, 2024

Язык: Английский

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Prevention and early intervention strategies for perinatal mental health disorders mediated by neuroimmune modulation and anti-inflammatory mechanisms through non-invasive transcranial magnetic stimulation: A narrative review

Brain Behavior and Immunity Integrative, Год журнала: 2025, Номер unknown, С. 100103 - 100103

Опубликована: Янв. 1, 2025

Язык: Английский

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Paraventricular nucleus CRH neurons regulate acute lung injury via sympathetic nerve–neutrophil axis

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 5, 2025

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are severe conditions with high morbidity mortality, effective treatments limited. Neuroimmune interactions play a critical role in homeostasis, but it remains unclear if specific brain regions regulate inflammation. Here, we unveil the of neuroimmune signaling ALI, focusing on regulatory function corticotropin-releasing hormone (CRH) neurons paraventricular nucleus (PVN) hypothalamus. Using viral tracing, chemogenetic modulation, pharmacological interventions mouse models ALI induced by intranasal lipopolysaccharide cecal ligation puncture (CLP), found that activated CRH^PVN projected to lung. Activation these protected mice from death, reducing neutrophil infiltration effector functions In contrast, inhibiting exacerbated ALI. Notably, beneficial impact neuron activation is compromised pulmonary chemical sympathectomy or inhibition β₂-adrenergic receptor. These protective effects were dependent sympathetic nerves, norepinephrine released locally modulate via β₂-AR–β-arrestin2 signaling, NF-κB pathway. Our findings reveal brain-lung axis regulates immune responses suggesting novel therapeutic targets for ARDS.

Язык: Английский

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Factors influencing sepsis associated thrombocytopenia (SAT): A multicenter retrospective cohort study

PLoS ONE, Год журнала: 2025, Номер 20(2), С. e0318887 - e0318887

Опубликована: Фев. 10, 2025

Introduction Sepsis associated thrombocytopenia (SAT) is a common complication of sepsis. We designed this study to investigate factors influencing SAT. Methods Patients with sepsis (2984 in Peking union medical college hospital [PUMCH] database, 13165 eICU Collaborative Research [eICU] 11101 Medical Information Mart for Intensive Care IV [MIMIC-IV] database) were enrolled. Variables included basic information, comorbidities, and organ functions. Multi-variable logistic regression models artificial neural network model applied determine the related Main results Age body mass index (BMI) inversely correlated incidence SAT (p-value 0.175 0.049 [PUMCH], p-value 0.000 [eICU], [MIMIC-IV]). Hematologic malignancies other positively 0.020 [MIMIC-IV]) except was PUMCH database. Norepinephrine (NE) equivalents, total bilirubin (TBIL) creatinine 0.000, 0.011 0.028, 0.013 0.027 PaO2 / FiO2 database 0.021 [PUMCH]), while it not 0.111 [eICU]). TBIL, hematologic malignancies, NE equivalents ranked top five significant variables all three datasets. Conclusions TBIL

Язык: Английский

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Plastic sex-trait modulation by differential gene expression according to social environment in male red deer

BMC Genomics, Год журнала: 2025, Номер 26(1)

Опубликована: Фев. 18, 2025

Mate competition encourages individuals to modulate characters involved in mating success. Adult Iberian red deer (Cervus elaphus hispanicus) males show a dark ventral patch (DVP) that plays central role rivalry, whose size and chemical compounds varied according the level of male-male within population. In pigmentation DVP appears, after urinary excretion, molecule called DOPEG originating from metabolism norepinephrine, leading us investigate whether differential expression mechanisms key genes dopamine B-hydroxylase (DBH) tyrosine hydroxylase (TH), encoding enzymes catalyzing process can be sensitive different competitive population situations responsible for plastic development deer. We found social environment with higher intrasexual competition, where male invest more sexual traits, was associated increased levels DBH TH transcripts, while Dopamine showed reversed values. alternative splicing gene, although differences between environments appeared just related levels. Our results support internal cause trait modulation based on gene relation conditions environment. propose quantification transcripts as molecular biomarker reproductive activity.

Язык: Английский

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Comparative metabolomic analysis reveals shared and unique features of COVID-19 cytokine storm and surgical sepsis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 24, 2025

The clinical manifestations of the cytokine storm (CS) associated with COVID-19 resemble acute phase sepsis. Metabolomics may contribute to understanding specific pathobiology these two syndromes. aim this study was compare serum metabolomic profiles in CS vs. septic surgery patients. In a retrospective cross-sectional study, samples from patients COVID-19, and without comorbidity, as well surgical sepsis were investigated. Targeted analysis performed on all using LC–MS/MS. Analysis revealed that similar alterations metabolome amino acid metabolism, nitrogen inflammatory status, methionine cycle glycolysis. most significant difference found for levels metabolites kynurenine synthesis, tricarboxylic cycle, gamma-aminobutyric niacinamide. metabolic pathway cysteine metabolism significantly disturbed For first time, similarities differences between investigated Northwest Russian Federation.

Язык: Английский

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From Discrimination to Disease: The Role of Inflammation

Harvard Review of Psychiatry, Год журнала: 2025, Номер 33(2), С. 83 - 89

Опубликована: Март 1, 2025

Abstract Discrimination is an established social determinant of mental health that contributes to psychiatric illness disparities among marginalized populations. There emerging research elucidating the biological mechanisms connecting discrimination outcomes, revealing inflammation as a key pathway. This column synthesizes evidence from existing literature on links between and inflammation, outlines both opportunities challenges in this field. The discussion highlights necessity multifaceted approach address discrimination, thus, reduce at individual population levels.

Язык: Английский

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Catecholamines in sepsis: pharmacological insights and clinical applications—a narrative review

Journal of Anesthesia Analgesia and Critical Care, Год журнала: 2025, Номер 5(1)

Опубликована: Апрель 3, 2025

Язык: Английский

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Early fluid plus norepinephrine resuscitation diminishes kidney hypoperfusion and inflammation in septic newborn pigs

Shock, Год журнала: 2024, Номер unknown

Опубликована: Апрель 23, 2024

Sepsis is the most frequent risk factor for acute kidney injury (AKI) in critically ill infants. Sepsis-induced dysregulation of microcirculation newborns unresolved. The objective this study was to use translational swine model evaluate changes function during early phase sepsis and impact fluid plus norepinephrine resuscitation. Newborn pigs (3-7-day-old) were allocated randomly three groups: 1) sham, 2) (cecal ligation puncture) without subsequent resuscitation, 3) with lactated Ringer All animals underwent standard anesthesia mechanical ventilation. Cardiac output glomerular filtration rate measured noninvasively. Mean arterial pressure, total renal blood flow, cortical perfusion, medullary tissue oxygen tension (mtPO 2 ) determined 12 h. Cecal puncture decreased mean pressure cardiac by more than 50%, a proportional increase vascular resistance 60-80% reduction mtPO compared sham. also ~79% increased AKI biomarkers. Isolated foci tubular necrosis observed septic piglets. Except , all these parameters ameliorated resuscitated Resuscitation attenuated sepsis-induced increases levels plasma C-reactive protein, proinflammatory cytokines, lactate dehydrogenase, alanine transaminase, aspartate aminotransferase, NLRP3 inflammasome. These data suggest that newborn subjected cecal develop hypodynamic AKI. Early implementation resuscitation lessens degree inflammation, AKI, liver injury.

Язык: Английский

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