Advances in molecular oncology,
Год журнала:
2024,
Номер
11(4), С. 8 - 22
Опубликована: Дек. 9, 2024
Recent
development
of
molecular
and
genetic
technologies
has
demonstrated
at
the
level
co-evolutionary
principles
interaction
between
microbiota,
virome
host
organism,
as
well
role
microorganisms
viruses
both
in
maintaining
physiological
homeostasis
various
diseases,
including
malignant
neoplasms.
The
presented
review
is
devoted
to
analysis
generalization
modern
data
on
inhabiting
human
body,
their
processes
initiation,
promotion
progression
carcinogenesis.
provides
information
known
oncogenic
according
classification
carcinogenic
agents
International
Agency
for
Research
Cancer.
Mechanistic
procarcinogenic
effect
microbiota
are
considered
accordance
with
concept
key
characteristics
a
agent.
Particular
attention
paid
influence
immunity
first
results
immunotherapy
Coley
toxin
soft
tissue
sarcomas
osteosarcomas,
individual
types
formation
immunocompetent
cell
profile
organism.
In
addition,
intratumor
intracellular
respectively,
microenvironment
tumor
cells
cellular
signaling,
solid
tumors
that
have
no
contact
external
environment
also
discussed.
important
terms
holobiota
concept,
showing
interdependent
existence
viruses,
improve
prevention
therapy
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Май 20, 2025
Microorganisms
in
the
human
body
play
crucial
roles
various
health
and
disease
processes.
Research
indicates
that
diverse
bacterial
species
are
implicated
numerous
cancer
types.
Apart
from
its
involvement
initiation
progression,
microbiome
holds
promise
as
a
biomarker
for
diagnosing
cancer,
assessing
risk,
determining
prognosis.
Intratumoral
microbes
profoundly
impact
tumor
biology
by
regulating
progression
of
tumors
modulating
their
response
to
chemotherapy,
radiotherapy,
immunotherapy.
A
deeper
understanding
role
intratumoral
requires
further
investigation
into
effects
underlying
mechanisms.
This
review
delves
significance
bacteria
initiation,
metastasis,
on
treatment
outcomes,
Approaches
Employed
Profiling
Microbiome.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(18), С. 10120 - 10120
Опубликована: Сен. 20, 2024
Immune
checkpoint
inhibitors
(ICIs)
have
transformed
cancer
treatment
by
enhancing
anti-tumour
immune
responses,
demonstrating
significant
efficacy
in
various
malignancies,
including
melanoma.
However,
over
50%
of
patients
experience
limited
or
no
response
to
ICI
therapy.
Resistance
ICIs
is
influenced
a
complex
interplay
tumour
intrinsic
and
extrinsic
factors.
This
review
summarizes
current
for
melanoma
the
factors
involved
resistance
treatment.
We
also
discuss
emerging
evidence
that
microbiota
can
impact
outcomes
modulating
biology
function.
Furthermore,
profiles
may
offer
non-invasive
method
predicting
response.
Therefore,
future
research
into
manipulation
could
provide
cost-effective
strategies
enhance
improve
patients.
Bone Reports,
Год журнала:
2024,
Номер
23, С. 101809 - 101809
Опубликована: Окт. 11, 2024
Emerging
insights
in
osteoimmunology
have
enabled
researchers
to
explore
depth
the
role
of
immune
modulation
regulating
bone
health.
Bone
is
one
common
sites
metastasis
notably
case
breast
cancer,
prostate
cancer
and
several
other
types.
High
calcium
ion
concentration
presence
factors
within
mineralized
matrix
including
TGF-β,
BMP
etc.,
aid
tumor
growth
proliferation.
Accumulating
evidence
has
substantiated
gut-microbiota
(GM)
tumorigenesis,
further
providing
a
strong
impetus
for
growing
"immune-cancer-gut
microbiota"
relationship.
Recent
advancements
research
highlight
importance
intra-tumor
microbiota
conjunction
with
GM
metastasis.
Intratumoral
owing
their
ability
cause
genetic
instability,
mutations,
epigenetic
modifications
microenvironment,
been
recognized
affect
cell
physiology.
The
host
system
crosstalk
shapes
innate
adaptive
arms
system,
which
key
player
progression.
In
this
review,
we
aim
decipher
microorganisms
mediating
by
shedding
light
on
immuno-onco-microbiome
(IOM)
axis.
We
discussed
feasible
therapeutic
interventions
based
microbiome-immune
axis
includes
prebiotics,
probiotics,
postbiotics.
Here,
leverage
conceptual
framework
published
articles
microbiota-based
therapies
target
metastases.
Understanding
complicated
nexus
will
provide
into
fundamental
governing
metastases
subsequently
help
managing
malignancy
better
efficacy.
Advances in molecular oncology,
Год журнала:
2024,
Номер
11(4), С. 8 - 22
Опубликована: Дек. 9, 2024
Recent
development
of
molecular
and
genetic
technologies
has
demonstrated
at
the
level
co-evolutionary
principles
interaction
between
microbiota,
virome
host
organism,
as
well
role
microorganisms
viruses
both
in
maintaining
physiological
homeostasis
various
diseases,
including
malignant
neoplasms.
The
presented
review
is
devoted
to
analysis
generalization
modern
data
on
inhabiting
human
body,
their
processes
initiation,
promotion
progression
carcinogenesis.
provides
information
known
oncogenic
according
classification
carcinogenic
agents
International
Agency
for
Research
Cancer.
Mechanistic
procarcinogenic
effect
microbiota
are
considered
accordance
with
concept
key
characteristics
a
agent.
Particular
attention
paid
influence
immunity
first
results
immunotherapy
Coley
toxin
soft
tissue
sarcomas
osteosarcomas,
individual
types
formation
immunocompetent
cell
profile
organism.
In
addition,
intratumor
intracellular
respectively,
microenvironment
tumor
cells
cellular
signaling,
solid
tumors
that
have
no
contact
external
environment
also
discussed.
important
terms
holobiota
concept,
showing
interdependent
existence
viruses,
improve
prevention
therapy
