Administration Strategy-Dependent Mechanisms and Effects of Human Adipose Tissue Stem Cell Extracellular Vesicles in Mouse Allergic Rhinitis Treatment
Cell Transplantation,
Год журнала:
2025,
Номер
34
Опубликована: Апрель 1, 2025
We
previously
found
that
intravenous
injection
of
extracellular
vesicles
(EVs)
from
human
adipose
tissue–derived
stem
cells
(hADSC)
could
ameliorate
allergic
rhinitis
(AR)
in
mice
through
immunomodulatory
effects.
In
clinical
trials,
nasal
delivery
has
been
an
attractive
treatment
for
AR.
sought
to
determine
whether
there
are
differences
the
therapeutic
effects
between
caudal
and
their
combination.
treated
AR
with
ADSC-EVs
via
vein,
cavity,
or
both.
After
treatment,
were
re-sensitized
indices
behavior,
mucosa
morphology,
cytokine
secretion
under
different
modes
administration
calculated.
The
resultes
show
tail
nasal,
combined
effectively
relieve
inflammatory
infiltration
mice,
reduce
IgE,
IL-4,
other
factors,
alleviate
Th1/Th2
imbalance.
Injection
delivery,
as
well
combination,
alleviated
symptoms
mice.
Nasal
a
better
effect
when
response
is
mild.
It
be
speculated
have
excellent
properties
AR,
can
selected
stages
therapy.
Язык: Английский
The Immunomodulatory mechanism and research progress of mesenchymal stem cells in the treatment of allergic rhinitis
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Апрель 18, 2025
Allergic
rhinitis
(AR)
affects
10-40%
of
the
global
population,
yet
current
therapies
(drugs,
immunotherapy)
face
limitations
in
efficacy
and
safety.
Mesenchymal
stem
cells
(MSCs)
have
emerged
as
a
promising
alternative
due
to
their
immunomodulatory
properties.
Preclinical
studies
demonstrate
that
MSCs
from
adipose,
bone
marrow,
umbilical
cord,
tonsils
reduce
AR
symptoms
(sneezing,
nasal
inflammation)
serum
IgE
(Immunoglobulin
E)
levels
by
restoring
Th1/Th2
immune
equilibrium
enhancing
Treg
(Regulatory
T
cells)
activity.
MSC-derived
exosomes
hydrogel-encapsulated
formulations
further
improve
targeting
However,
clinical
translation
is
hindered
heterogeneous
protocols
unresolved
long-term
risks
(e.g.,
tumorigenicity).
MSC-based
offer
potential
for
durable
remission
addressing
dysregulation
at
its
root.
Future
efforts
must
prioritize
standardized
production,
phase
I
safety
trials,
combination
strategies
+
hydrogels)
accelerate
adoption.
Язык: Английский
Functions and Clinical Applications of Extracellular Vesicles in TH2 Cell-Mediated Airway Inflammatory Diseases: A Review
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(17), С. 9455 - 9455
Опубликована: Авг. 30, 2024
Type
2
airway
inflammation
(T2AI),
driven
by
type
innate
lymphoid
and
CD4
Язык: Английский
Mesenchymal stem cell-derived extracellular vesicles in systemic sclerosis: role and therapeutic directions
Frontiers in Cell and Developmental Biology,
Год журнала:
2024,
Номер
12
Опубликована: Окт. 17, 2024
Systemic
sclerosis
(SSc)
is
a
complex
autoimmune
disease
with
clinical
symptoms
of
vascular
damage,
immune
disorders,
and
fibrosis,
presenting
significant
treatment
challenges
limited
therapeutic
options.
Mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
have
been
demonstrated
in
numerous
studies
as
more
effective
than
MSCs
treating
diseases.
Recent
demonstrate
that
MSC-EVs
can
significantly
ameliorate
the
SSc
mitigate
pathological
changes
such
injury,
dysregulation,
fibrosis.
These
findings
underscore
promising
potential
SSc.
promote
angiogenesis,
modulate
dysfunction,
combat
This
article
summarizes
applications
possible
mechanisms
for
SSc,
thereby
offering
novel
direction
Язык: Английский
Immunomodulatory effect of mesenchymal stem cells‐derived extracellular vesicles to modulate the regulatory T cells and Th1/Th2 imbalance in peripheral blood mononuclear cells of patients with allergic rhinitis
Scandinavian Journal of Immunology,
Год журнала:
2024,
Номер
100(6)
Опубликована: Окт. 29, 2024
Mesenchymal
stem
cell-derived
extracellular
vesicles
(MSC-EVs)
have
shown
promising
immunomodulatory
capabilities
for
a
variety
of
clinical
conditions.
However,
the
potential
regulatory
mechanisms
MSC-EVs
in
allergic
rhinitis
(AR)
remain
unexplored.
The
present
study
was
designed
to
investigate
effect
patients
with
AR.
Peripheral
blood
mononuclear
cells
(PBMCs)
were
isolated
from
AR
patients.
number
peripheral
CD4
Язык: Английский