The association between the neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio and delirium in ischemic stroke patients

Frontiers in Medicine, Год журнала: 2025, Номер 11

Опубликована: Янв. 6, 2025

Delirium is a severe neuropsychiatric symptom following acute ischemic stroke (IS) and associated with poor outcomes. Systemic inflammation immune dysregulation are believed to contribute the pathophysiology of delirium. The neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR) widely recognized as convenient reliable biomarkers systemic inflammation. However, their association delirium after IS remains unclear. In this study, we identified patients requiring ICU admission from Medical Information Mart for Intensive Care (MIMIC)-IV database. We employed multivariable logistic regression restricted cubic splines (RCS) assess between NLR, PLR, LMR Two-sample Mendelian randomization (MR) analysis was performed further explore causal relationship at genetic level. A total 1,436 were included in whom 214 (14.9%) had multivariate analysis, adjustment confounders, highest quartile NLR (odds [OR] 2.080, 95% confidence interval [CI], 1.282-3.375) (OR 0.503, CI 0.317-0.798) second PLR 1.574, 1.019-2.431) significantly RCS function showed progressive increase risk higher lower LMR. MR only negatively observational studies found significant associations demonstrated potential protective Further prospective needed validate elucidate underlying mechanisms.

Язык: Английский

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Associations between neutrophil percentage to albumin ratio and rheumatoid arthritis versus osteoarthritis: a comprehensive analysis utilizing the NHANES database

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Янв. 23, 2025

Objectives The association between the neutrophil percentage to albumin ratio (NPAR) and risk of osteoarthritis (OA) rheumatoid arthritis (RA) remains unclear. This study aims investigate NPAR OA RA. Methods cross-sectional analyzed data from 92,062 American adults in NHANES database 1999 2016. Various statistical analyses were conducted associations risks RA, including multivariable logistic regression, subgroup analysis, smooth curve fitting, threshold effect analysis. Results After screening, final population included 36,147 participants, with 3,881 individuals diagnosed 2,178 adjusting for confounding factors, higher levels associated an increased RA (OR=1.05; 95% CI: 1.03-1.07; P <0.0001), but not (OR=1.01; 0.99-1.02; =0.755). was remarkably consistent across subgroups by age, sex, body mass index (BMI), alcohol consumption, hypertension, diabetes, smoking status. Further using fitting models revealed a nonlinear inflection point identified at 15.56. Conclusion High is positively prevalence provides us new insights management treatment patients.

Язык: Английский

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Association of advanced lung cancer inflammation index with all-cause and cardiovascular mortality in US patients with rheumatoid arthritis

Frontiers in Nutrition, Год журнала: 2024, Номер 11

Опубликована: Май 30, 2024

Introduction As a systemic autoimmune disorder, the prognosis of rheumatoid arthritis (RA) is intricately linked to inflammation. This study aimed investigate association between advanced lung cancer inflammation index (ALI), comprehensive indicator combined with nutritional status, and all-cause cardiovascular mortality among patients diagnosed RA. Methods The 2,305 RA from NHANES (2001–2018) included in analysis were categorized into three groups according ALI tertiles. Weighted Kaplan–Meier multivariate COX regression analyses evaluated relationship mortality. time-dependent characteristic curve (ROC) was used assess prediction accuracy ALI. Results During median follow-up 7.92 years, 591 participants died all causes, including 197 diseases. Increased associated decreased probability death. full model revealed lower hazard risks T2 (HR: 0.67, 95%CI: 0.54–0.83) T3 0.47 0.33–0.67, p for tend <0.001) compared T1, risk also 0.47, 0.31–0.70) 0.34, 0.19–0.62, trend <0.001). Furthermore, ROC underscored strong predictive capability (AUC 1-year 0.73 0.79, respectively). Conclusion cohort demonstrated higher predicting patients, highlighting important clinical value assessment evaluation.

Язык: Английский

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Association between the advanced lung cancer inflammation index and all-cause and cardiovascular mortality in patients with RA: Insights from NHANES data analysis

Heliyon, Год журнала: 2024, Номер 10(13), С. e33673 - e33673

Опубликована: Июнь 27, 2024

Rheumatoid arthritis (RA) is associated with significant mortality, which primarily due to cardiovascular complications. Despite advancements in RA treatment, mortality rates remain high, highlighting the need for reliable prognostic markers. The advanced lung cancer inflammation index (ALI), integrates inflammatory and nutritional biomarkers, has shown promise predicting outcomes various medical conditions. However, its role prognosis remains unclear.

Язык: Английский

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Diagnostic Value of Neutrophil-to-Lymphocyte Ratio (NLR) in Intrahepatic Cholestasis of Pregnancy

British Journal of Hospital Medicine, Год журнала: 2025, Номер unknown, С. 1 - 10

Опубликована: Янв. 9, 2025

Aims/Background Intrahepatic cholestasis of pregnancy (ICP) is associated with adverse perinatal outcomes, yet the correlation between ICP and neutrophil-to-lymphocyte ratio (NLR) remains unclear. This study aims to investigate diagnostic value NLR in ICP. Methods In this retrospective case-control study, 113 patients treated Beilun District People's Hospital from January 2020 December 2022 were recruited categorized as group, 209 healthy pregnant women during same period selected control group. The levels mean platelet volume (MPV) compared two groups. different severity compared. Logistic regression model was used analyze relationship relevant indicators capability predicting evaluated using receiver operating characteristic (ROC) curves. Results There significant differences age, neutrophil count, lymphocyte MPV, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate (AST), NLR, serum total bile acid (sTBA) among all groups (p < 0.05). severe group significantly higher than that mild analysis showed MPV (odds [OR] = 1.247) (OR 1.885) independent factors influencing occurrence ROC curve area under (AUC) for both 0.679 0.869, respectively, substantiating NLR. Conclusion can be an auxiliary indicator diagnosis has important clinical outcomes patients.

Язык: Английский

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Elevated neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are associated with increased flares and elevated cardiovascular disease risk in gout

Scandinavian Journal of Rheumatology, Год журнала: 2025, Номер unknown, С. 1 - 5

Опубликована: Янв. 17, 2025

Objective Although gout is the most common inflammatory arthritis, there are few tools to monitor disease activity and predict complications in patients. The neutrophil-to-lymphocyte ratio (NLR) monocyte-to-lymphocyte (MLR) associated with various diseases NLR has been shown coronary artery severity, a comorbid condition gout. Thus, we evaluated use of MLR as novel biomarkers measure cardiovascular (CVD) risk

Язык: Английский

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Inflammatory and Cardiovascular Responses to Active and Passive Acute Psychological Stress

Опубликована: Фев. 1, 2025

Acute psychological stress is a risk factor for cardiovascular disease (CVD), possibly through promoting heightened inflammatory profile. Active stressors are commonly used to investigate and immune reactivity; however, this response may not translate other modalities. We aimed decipher potential differences in responses passive active stressors. Eighty-eight participants completed study. After baseline period, (International Affective Picture System [IAPS]) task (Paced Auditory Serial Addition Test [PASAT]) were randomized order, with 45-minute rest post-tasks. Cardiovascular measures (including SBP, DBP, HR) collected continuously. Blood samples after each time point determining responses, including circulating stimulated interleukin-6 (IL-6), systemic inflammation index (SIRI), neutrophil/lymphocyte ratio (NLR), TNF-α, P- E-selectin. higher during the PASAT than IAPS (p < .001). Circulating IL-6 levels increased from 45-minutes both tasks ≤ .001), no difference between post-PASAT post-IAPS > .05). SIRI = .013), .004), No existed. NLR .008). There significant effects P-selectin, or E-selectin (all p Both SIRI. task, but magnitude of did significantly differ tasks. Regardless modality, an ensues, potentially increasing CVD over time.

Язык: Английский

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The Value of NLR and PLR in the Diagnosis of Rheumatoid Arthritis Combined with Interstitial Lung Disease and Assessment of Treatment Effect: A Retrospective Cohort Study

International Journal of General Medicine, Год журнала: 2025, Номер Volume 18, С. 867 - 880

Опубликована: Фев. 1, 2025

This retrospective cohort study investigated the value of neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte (PLR) in diagnosis treatment rheumatoid arthritis complicated with interstitial lung disease (RA-ILD). A total 163 patients newly diagnosed (RA) were enrolled, 122 RA group 41 RA-ILD group. The mean age was 63.84 ± 8.53 years, a male-to-female 14:47. had 66.29 12.72 13:28. During 2-year follow-up period, 10 developed (ILD). NLR PLR significantly higher than (p < 0.05). optimal critical values for 3.15 152.62, area under ROC curve 0.615 0.61, sensitivity 72%, 62%, specificity 54% 64%. increased after ILD during but decreased predicted percentage vital capacity (VC%), forced (FVC%), expiratory volume first second (FEV1%) carbon monoxide dispersion (DLcoSB%) Moreover, treatment. While VC%, FVC%, FEV1%, DLcoSB% negatively correlated FVC% both before also When increase, we should be alert to possibility ILD, which can used as an evaluation index effect RA-ILD.

Язык: Английский

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Accelerated aging mediates the association between rheumatoid arthritis and depression severity

Journal of Affective Disorders, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

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The combined impact of neutrophil-percentage-to-albumin ratio and depressive symptoms on mortality in US arthritis patients: insights from NHANES (2005–2018)

Frontiers in Public Health, Год журнала: 2025, Номер 13

Опубликована: Март 6, 2025

Background The neutrophil-to-albumin ratio (NPAR) reflects inflammation and nutritional status, while depression significantly impacts survival in chronic disease patients. This study examines the independent combined effects of NPAR depressive symptoms on all-cause cardiovascular mortality arthritis Methods We analyzed a nationally representative sample people with arthritisaged 40 older from NHANES (2005–2018). assessed were measured by PHQ-9. Weighted Cox regression examined joint associations PHQ-9 (CVD) mortality. Results Our analysis indicated that higher levels lower (PHQ-9 &lt; 10) increased CVD risks In this group, hazard (HR) for was 2.087, similarly elevated risk (HR = 2.614), underscoring NPAR’s predictive strength non-depressed individuals. Among those symptoms, still associated mortality, its impact less marked, highlighting need further research into NPAR-depression interaction. Conclusion identifies as key predictor patients, particularly fewer symptoms. predicts value an nutrition biomarker. Integrating clinical practice could enhance individualized assessment intervention

Язык: Английский

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