Diabetology International, Год журнала: 2024, Номер 15(4), С. 761 - 776
Опубликована: Сен. 11, 2024
Язык: Английский
Pharmaceuticals, Год журнала: 2025, Номер 18(1), С. 128 - 128
Опубликована: Янв. 18, 2025
Background/Objectives: Influenza is a major global health challenge, causing thousands of deaths annually. Antiviral drugs, particularly oseltamivir, neuraminidase inhibitor, have become essential therapeutic options due to their oral bioavailability and efficacy. Previous studies suggest potential association between oseltamivir use the onset diabetes mellitus. However, further investigation needed establish definitive link. Methods: This retrospective cohort study utilized data from Taiwan National Health Insurance Research Database (NHIRD), including 1,631,968 patients (815,984 users) 1 January 2009 28 December 2018. All statistical analyses were performed using SAS 9.4M8 software (SAS Institute Inc., Cary, NC, USA). Results: Cox proportional hazards regression multivariate revealed statistically significant overall risk (HR = 1.027, p 0.0186). While no was observed for Type 1.021; 0.06795), users showed higher incidence 2 1.024; < 0.05). Oseltamivir also linked increased risks comorbidities, dyslipidemia 1.295, 0.0001), chronic liver disease 1.446, hypertension 1.586, obesity 2.949, 0.0001). Conclusions: associated with an but not 1, related comorbidities.
Язык: Английский
Процитировано
1
Reviews in Endocrine and Metabolic Disorders, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 19, 2024
Abstract Despite over a century of insulin therapy and recent advances in glucose monitoring, diabetes its complications remain significant burden. Current medications are not durable, with symptoms often returning after treatment ends, responses vary between patients. Additionally, the effectiveness many diminishes time, highlighting need for alternative approaches. Maintaining β-cell mass promoting regeneration offer more curable treatments, while cell replacement therapies could be an option if is feasible. For both strategies, enhancing survival crucial. Growth hormone-releasing hormone (GHRH) was originally discovered ability to stimulate production release growth (GH) from pituitary. Beyond hypothalamus, GHRH produced peripheral tissues, receptor, GHRHR, expressed tissues such as pituitary, pancreas, adipose tissue, intestine, liver. Several studies have shown that analogs enhance insulin-producing pancreatic β-cells vitro animal models. These beneficial effects strongly support potential agonists antagonists clinical human metabolic diseases or cells used transplantation. In current review, we will discuss roles hypothalamic extrahypothalamic metabolism physiological pathological contexts, along underlying mechanisms. Furthermore, diseases.
Язык: Английский
Процитировано
4
Journal of Autoimmunity, Год журнала: 2024, Номер 147, С. 103276 - 103276
Опубликована: Июнь 26, 2024
Язык: Английский
Процитировано
3
Cellular and Molecular Life Sciences, Год журнала: 2025, Номер 82(1)
Опубликована: Янв. 23, 2025
Abstract Enteroviruses can infect various human organs, causing diseases such as meningitis, the common cold, hand-foot-and-mouth disease, myocarditis, pancreatitis, hepatitis, poliomyelitis, sepsis, and type 1 diabetes. Currently, there are no approved treatments for enterovirus infections. In this study, we identified a synergistic combination of orally available, safe-in-man pleconaril, AG7404, mindeudesivir, that at non-toxic concentrations effectively inhibited replication in cell organoid cultures. Importantly, cocktail did not alter glucose insulin levels culture medium pancreatic β-cells preserved contraction rhythm infected heart organoids. These findings highlight promising drug further preclinical studies clinical trials targeting broad range enterovirus-mediated diseases.
Язык: Английский
Процитировано
0
Drugs, Год журнала: 2025, Номер unknown
Опубликована: Янв. 28, 2025
Язык: Английский
Процитировано
0
Clinical Reviews in Allergy & Immunology, Год журнала: 2025, Номер 68(1)
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
0
Healthcare, Год журнала: 2025, Номер 13(5), С. 496 - 496
Опубликована: Фев. 25, 2025
Background/Objectives: Continuous glucose monitoring (CGM) has emerged as an important tool for the improvement of glycemic control in individuals with type 1 diabetes (T1D). However, its use not been greatly explored among adolescents special physiological and psychosocial challenges. This study evaluated role CGM supporting high-risk T1D Saudi Arabia. Methods: retrospective observational was conducted 73 aged 12-19 baseline HbA1c ≥ 9% treated at King Khalid University Hospital Riyadh, Data were extracted from electronic health records over a three-month period. The levels before after analyzed using paired t-tests. In addition, analyses included studying correlations regression models assessing associations between changes patient characteristics. Results: Mean significantly reduced 9.48 ± 2.22% to 9.06 1.91% following three months CGM, average decrease -0.42 1.37%, p = 0.011. Changes did correlate various factors interest: age, gender, body mass index, disease duration, insulin type. Within specified timeframe, 54.8% patients reported hypoglycemia, 38.4% diabetic ketoacidosis. Conclusions: resulted small but statistically significant T1D. Given such results, these findings highlight need larger, long-term trials optimize this vulnerable population, particularly through integrating advanced features (e.g., predictive alarms) structured education programs reduce hypoglycemia DKA risks. Effective integration daily management may lead better clinical outcomes improved quality life adolescents.
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2025, Номер unknown
Опубликована: Март 26, 2025
Autoimmune disorders, including type 1 diabetes mellitus (T1DM) and systemic lupus erythematosus (SLE), are influenced by a combination of genetic, environmental, immunological factors. Among these, stress, both physical psychological, has been increasingly recognized as significant contributor to disease onset progression. This review explores the current literature on relationship between stress autoimmune diseases, focusing neuroendocrine pathways, such hypothalamic-pituitary-adrenal (HPA) axis, effects glucocorticoids immune modulation. These mechanisms contribute clinical manifestations, flares or progression, highlighting impact patient outcomes. Evidence suggests that psychological can precipitate T1DM in genetically predisposed individuals, with disruptions occurring before diagnosis. In SLE, acute chronic particularly trauma-induced linked increased activity flare-ups, largely due stress-induced dysregulation disrupts balance pro-inflammatory anti-inflammatory cytokines. Despite substantial evidence supporting role exacerbation, further research is necessary fully understand which influences diseases develop effective management.
Язык: Английский
Процитировано
0
PLoS ONE, Год журнала: 2025, Номер 20(4), С. e0319756 - e0319756
Опубликована: Апрель 9, 2025
Together with their nutritional qualities, the biosafety, antidiabetic, antioxidant, and anti-inflammatory effects of Tetracarpidium conophorum nuts, Persea americana seeds, Terminalia cattapa kernels were evaluated in vitro silico. RBC membrane stabilisation for characteristics, antioxidant activities by ABTS, DPPH, H2O2, nitric oxide scavenging assays, α-glucosidase α-amylase inhibitory assays conducted used to evaluate anti-diabetic activity. With an IC50 value 208 μg/mL , P. showed maximum amount inhibition, according results, while T. catappa a somewhat lower degree inhibition at 236 . exhibited highest 312 µg/mL. strongest DPPH radical activity, ABTS effectiveness neutralising hydrogen peroxide. In tests using human red blood cells, hemolysis. While higher concentrations copper, manganese, potassium, calcium, magnesium concentrations. had considerably levels ash, proteins, lipids, carbohydrates than which quantity crude fibre, proximate analysis. Molecular docking experiments have revealed that plant extracts from americana, substantial binding affinities towards amylase. Pseudococaine, M-(1-methylbutyl) phenylmethylcarbamate, o-xylene, 1-deoxynojirimycin four compounds those acarbose. Acarbose nitrate not as compatible scores compared dimethyl phthalate, pseudococaine, M-(1-Methylbutyl)phenyl methylcarbamate, 2-chloro-3-oxohexanedioic acid, methyl 2-chloro-5-nitrobenzoate. These results suggest these hold great potential creation therapeutic medications specifically target oxidative stress-related diseases like diabetes.
Язык: Английский
Процитировано
0
Вопросы современной педиатрии, Год журнала: 2025, Номер 24(2), С. 76 - 82
Опубликована: Май 18, 2025
Background . The hypothesis on correlation between SARS-CoV-2 infection and diabetic ketoacidosis (DKA) development in patients with newly diagnosed type 1 diabetes (T1D) was proposed during the COVID-19 pandemic. results of testing this remain contradictory. Objective. Aim study — to analyse clinical characteristics T1D onset children. Methods included data from medical records hospitalized March 2020 2021. group IgG 10 U/ml at hospital admission, control no laboratory signs COVID-19. Clinical forms disease manifestation (hyperglycemia, ketosis, DKA) were recorded among features, as well DKA severity according blood pH levels (mild 7.3; moderate = 7.1–7.2; severe < 7.1). Results 119 children, 320 established T1D. Both groups comparable gender age. manifested hyperglycemia 35 (29.4%) patients, ketosis 41 (34.5%), 43 (36.1%) group; 81 (25.3%), 89 (27.8%) 150 (46.9%) group, respectively (p 0.127). mild 9 (20.9%), 24 (55.8%), (23.3%) 36 (24%), 73 (48.7%) (27.3%) 0.747). Conclusion : is not associated form onset.
Язык: Английский
Процитировано
0